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Immunity to Rotaviruses

  • R. Edelman
  • J. Flores
  • A. Z. Kapikian
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 146)

Abstract

Diarrhea is the principal cause of mortality in infants and young children in the developing countries of Asia, Africa, and Latin America where the syndrome accounts annually for 3–5 billion cases and approximately 5–10 million deaths (Institute of Medicine 1985; Walsh and Warren 1979). Another estimate which reviewed data from several longitudinal studies in children revealed that 4.6 million diarrhea deaths and 744 million to 1 billion episodes of diarrhea occurred in children less than 5 years of age in developing countries, excluding China (Snyder and Merson 1982). In developed countries diarrheal deaths occur infrequently but morbidity from diarrheal illness is high (Institute of Medicine 1986; Rodriguez et al. 1987).

Keywords

Oral Polio Vaccine Diarrheal Illness Heterotypic Immunity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Albert MJ, Unicomb LE, Bishop RF (1987) Cultivation and characterization of human rotaviruses with “super short” RNA patterns. J Clin Microbiol 25:183–185PubMedGoogle Scholar
  2. Barnes GL, Doyle LW, Hewson PH, Knocles AML, McLellan JA, Kitden WH, Bishop RF (1982) A randomized trial of oral gammaglobulin in low birth weight infants infected with rotavirus. Lancet i:1371–1373CrossRefGoogle Scholar
  3. Berger R, Hadziselimovic F, Just M, Reigel F (1984) Influence of breast milk on nosocomial rotavirus infection in infants. Infection 12:171–174PubMedCrossRefGoogle Scholar
  4. Birch CJ, Heath RL, Gust ID (1988) Use of serotype-specific monoclonal antibodies to study the epidemiology of rotavirus infection. J Med Virol 24:45–53PubMedCrossRefGoogle Scholar
  5. Bishop RF, Barnes GL, Cipriani E, Lund JS (1983) Clinical immunity after neonatal rotavirus infection: A prospective longitudinal study in young children. N Engl J Med 309:72–76PubMedCrossRefGoogle Scholar
  6. Black RE, Merson MH, Rahman ASMM, Yunus M, Alim ARMA, Huq I, Yolken RH, Curlin GT (1980) A two-year study of bacterial, viral, and parasitic agents associated with diarrhea in rural Bangladesh. J Infect Dis 5:660–664CrossRefGoogle Scholar
  7. Black RE, Merson MH, Huq I, Alim ARMA, Yunus M (1981) Incidence and severity of rotavirus and Escherichia coli diarrhea in rural Bangladesh: Implications for vaccine development. Lancet i:141–143CrossRefGoogle Scholar
  8. Black RE, Brown KH, Becker S, Alim ARMA (1982) Longitudinal studies of infectious diseases and physical growth of children in rural Bangladesh. II. Incidence of diarrhea and association with known pathogens. Am J Epidemiol 115:315–324PubMedGoogle Scholar
  9. Brandt CD, Kim HW, Rodriguez WJ, Arrobio JO, Jeffries BC, Stallings EP, Lewis C, Miles AJ, Chanock RM, Kapikian AZ, Parrott RH (1983) Pediatric viral gastroenteritis during eight years of study. J Clin Microbiol 18:71–78PubMedGoogle Scholar
  10. Chiba S, Yokoyama T, Nakata S, Morita K, Urasawa T, Taniguchi K, Urasawa S, Nakao T (1986) Protective effect of naturally acquired homotypic and heterotypic rotavirus antibodies. Lancet ii:417–421CrossRefGoogle Scholar
  11. Clark HF, Furukawa T, Bell LM, Offit PA, Perrella PA, Plotkin SA (1986) Immune response of infants and children to low passage bovine rotavirus (strain WC3). Am J Dis Child 140:350–356PubMedGoogle Scholar
  12. Clark HF, Hoshino Y, Bell LM, Groff J, Hess G, Brachman P, Offit PA (1987a) Rotavirus isolate W161 representing a presumptive new human serotype. J Clin Microbiol 25:1757–1762PubMedGoogle Scholar
  13. Clark HF, Borian FE, Modesto K, Rodden J, Bell LM, Plotkin SA (1987b) Recent progress in evaluating rotavirus vaccines for human infants in Program of the US-Japan virology panel meeting, December 1–4, Monterey, California (abstract)Google Scholar
  14. Coulson BS, Unicomb LE, Pitson GA, Bishop RF (1987) Simple and specific enzyme immunoassay using monoclonal antibodies for serotyping human rotavirususes. J Clin Microbiol 25:509–515PubMedGoogle Scholar
  15. De Mol P, Zissis G, Butzler JP, Mutwewingabo A, Andre FE (1986) Failure of live, attenuated oral rotavirus vaccine. Lancet ii:108CrossRefGoogle Scholar
  16. De Zoysa I, Feachem RG (1985) Interventions for the control of diarrhoeal diseases among young children: Rotavirus and cholera immunization. Bull WHO 63:569–583PubMedGoogle Scholar
  17. Flewett TH (1981) Clinical features of rotavirusus infection. In: Tyrrell DAJ, Kapikian AZ (eds) Virus Infections of the Gastrointestinal Tract. New York, Marcel Dekker, p 125Google Scholar
  18. Flores J, Perez I, White L, Perez MA, Kalica AR, Marquina R, Wyatt RG, Kapikian AZ, Chanock RM (1982) Genetic relatedness among human rotaviruses as determined by RNA hybridization. Infect Immunity 37:648–655Google Scholar
  19. Flores J, Perez-Schael I, Boeggeman E, White L, Perez M, Purcell R, Hoshino Y, Midthun K, Chanock RM, Kapikian AZ (1985a) Genetic relatedness among human rotaviruses. J Med Virol 17:135–143PubMedCrossRefGoogle Scholar
  20. Flores J, Midthun K, Hoshino Y, Green K, Gorziglia M, Kapikian AZ, Chanock RM (1986a) Conservation of the fourth gene among rotaviruses recovered from asymptomatic newborn infants and its possible role in attenuation. J Virol 60:972–979PubMedGoogle Scholar
  21. Flores J, Nakagomi O, Nakagomi T, Glass R, Gorziglia M, Askaa J, Hoshino Y, Perez-Schael I, Kapikian AZ (1986b) The role of rotaviruses in pediatric diarrhea. Pediatr Infect Dis 5:S53–S62PubMedCrossRefGoogle Scholar
  22. Flores J, Perez-Schael I, Gonzalez M, Garcia D, Perez M, Daoud N, Cunto W, Chanock RM, Kapikian AZ (1987) Protection against severe rotavirus diarrhoea by Rhesus rotavirus vaccine in Venezuelan infants. Lancet i:882–884CrossRefGoogle Scholar
  23. Gema G, Assarani N, Saraini A, Battaglia M (1985) Characterization of serotyes of human rotavirus strains by solid-phase immune electron microscopy. J Infect Dis 152:1143–1151CrossRefGoogle Scholar
  24. Glass R, Keith J, Nakagomi O, Nakagomi T, Askaa J, Kapikian AZ, Chanock RM, Flores J (1985) Nucleotide sequence of the structural glycoprotein VP-7 gene of Nebraska calf diarrhea virus rotavirus: Comparison with homologous genes from four strains of human and animal rotaviruses. Virology 141:292–298PubMedCrossRefGoogle Scholar
  25. Gorziglia M, Hoshino Y, Buckler-White A, Blumentals I, Glass R, Flores J, Kapikian AZ, Chanock RM (1986) Conservation of amino acid sequence of VP8 and cleavage region of 84-KDa outer capside protein among rotaviruses recovered from asymptomatic neonatal infection. Proc Natl Acad Sci USA 83:7039–7043PubMedCrossRefGoogle Scholar
  26. Green KY, Midthun K, Gorziglia M, Hoshino Y, Kapikian AZ, Chanock RM, Flores J (1987) Comparison of the amino acid sequences of the major neutralization protein of four human rotavirus serotypes. Virology 161:153–159PubMedCrossRefGoogle Scholar
  27. Greenberg HB, Valdesuso J, van Wyke K, Midthun K, Walsh M, McAuliffe V, Wyatt RG, Kalica AR, Flores J, Hoshino Y (1983) Production and preliminary characterization of monoclonal antibodies at two surface proteins of Rhesus rotavirus. J Virol 47:267–275PubMedGoogle Scholar
  28. Grimwood K, Abbott GD, Fergusson DM, Jennings LC, Allan JM (1983) Spread of rotavirus within families: A community-based study. Br Med J 287:575–577CrossRefGoogle Scholar
  29. Hanlon P, Hanlon L, Marsh V, Byass P, Shenton F, Hassan-king M, Jobe O, Sillah H, Hayes R, M’Boge BH, Whittle HC, Greenwood BM (1987) Trial of an attenuated bovine rotavirus vaccine (RIT 4237) in Gambian infants. Lancet i:1342–1345CrossRefGoogle Scholar
  30. Hjelt K, Grauballe PC, Andersen L, Schiotz PO, Howitz P, Krasilnikoff PA (1986) Antibody response in serum and intestine in children up to six months after a naturally acquired rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr 5:74–80PubMedCrossRefGoogle Scholar
  31. Hoshino Y, Wyatt RG, Greenberg HB, Hores J, Kapikian AZ (1984) Serotypic similarity and diversity of rotaviruses of mammalin and avian origin as studied by plaque reduction neutralization. J Infect Dis 149:694–702PubMedCrossRefGoogle Scholar
  32. Hoshino Y, Sereno MM, Midthun K, Flores J, Kapikian AZ, Chanock RM (1958a) Independent segregation of two antigenic specificities (VP3 and VP7) involved in neutralization of rotavirus infectivity. Proc Natl Acad Sci USA 82:8701–8704CrossRefGoogle Scholar
  33. Hoshino Y, Wyatt RG, Flores J, Midthun K, Kapikian AZ (1985b) Serotype characterization of rotaviruses derived from asymptomatic human neonatal infection. J Clin Microbiol 21:425–430PubMedGoogle Scholar
  34. Hoshino Y, Torres A, Aves TM, Flores J, Lin J, Sereno MM, Kapikian AZ (1987) Neutralization antibody response of gnotobiotic piglets after fetal infection and neonatal challenge with human rotavirus strains. J Infect Dis 156:1038–1040PubMedCrossRefGoogle Scholar
  35. Institute of Medicine (1985) New Vaccine Development, Establishing Priorities. Vol I. Washington, DC, National Academy PressGoogle Scholar
  36. Institute of Medicine (1986) New Vaccine Development. Establishing Priorities. Vol II. Washington, DC, National Academy PressGoogle Scholar
  37. Kalica AR, Greenberg HB, Wyatt RG, Flores J, Sereno MM, Kapikian AZ, Chanock RM (1981) Genes of human (strain WA) and bovine (strain UK) rotaviruses that code for neutralization and subgroup antigens. Virology 112:385–390PubMedCrossRefGoogle Scholar
  38. Kapikian AZ, Wyatt RG, Levine MM, Yolken RH, Vankirk DH, Dolin R, Greenberg HB, Chanock RM (1983) Oral administration of human rotavirus to volunteers: Induction of illness and correlates of resistance. J Infect Dis 147:95–106PubMedCrossRefGoogle Scholar
  39. Kapikian AZ, Hoshino Y, Flores Y, Midthun K, Glass RI, Nakagomi O, Nakagomi T, Chanock RM, Potash L, Levine MM, Dolin R, Wright PF, Belshe RE, Anderson EL, Vesikari T, Gothefors L, Wadell G, Perez-Schael I (1986a) Alternative approaches to the development of a rotavirus vaccine. In: Holmgren J, Lindberg A, Mollby R (eds) Development of Vaccines and Drugs Against Diarrhea, 11th Nobel conference, Stockholm 1985. Lund, Sweden, Studentlitteratur, p 192Google Scholar
  40. Rodriguez WJ, Kim HW, Arrobio O, Brandt CD, Chanock RM, Kapikian AZ, Wyatt R, Parrott RH (1977) Clinical features of acute gastroenteritis associated with human reo-virus-like agent in infants and young children. J Pediatr 91:188–193PubMedCrossRefGoogle Scholar
  41. Rodriguez WJ, Kim HW, Brandt CD, Schwartz RH, Gardner MK, Jeffries B, Parrott RH, Kaslow RA, Smith JI, Kapikian AZ (1987) Longitudinal study of rotavirus infection and gastroenteritis in families served by a pediatric medical practice: Clinical and epidemiological observations. Pediatr Infect Dis J 6:170–176PubMedCrossRefGoogle Scholar
  42. Senturia YD, Peckham CS, Cordery M, Chrystie IA, Banatvala JE, Andre FE (1987) Live attenuated oral rotavirus vaccine [letter]. Lancet ii:1091–1092CrossRefGoogle Scholar
  43. Shaw RD, Stoner-Ma DL, Estes MK, Greenberg HB (1985) Specific enzyme-linked immunoassay for rotavirus serotypes 1 and 3. J Clin Microbiol 22:286–291PubMedGoogle Scholar
  44. Shaw RD, Fong KJ, Losonsky GA, Levine MM, Maldonado Y, Yolken R, Flores J, Kapikian AZ, Vo PT, Greenberg HB (1987) Epitope-specific immune responses to rotavirus vaccination. Gastroenterology 93:941–950PubMedGoogle Scholar
  45. Snodgrass DR, Wells PW (1976) Rotavirus infection in lambs: Studies on passive protection. Arch Virol 52:201–205PubMedCrossRefGoogle Scholar
  46. Snyder JD, Merson MH (1982) The magnitude of the global problem of acute diarrhoeal disease: A review of active surveillance data. Bull WHO 60:605–613PubMedGoogle Scholar
  47. Taniguchi K, Urasawa S, Urasawa T (1985) Preparation and characterization of neutralizing monoclonal antibodies with different reactivity patterns to human rotaviruses. J Gen Virol 66:1045–1053PubMedCrossRefGoogle Scholar
  48. Vesikari T, Isolauri E, D’Hondt E, Delem A, Andre FE (1984a) Increased take rate of oral rotavirus vaccine in infants after milk feeding. Lancet ii:700CrossRefGoogle Scholar
  49. Vesikari T, Isolauri E, D’Hondt E, Delem A, Andre F, Zissis G (1984b) Protection of infants against rotavirus diarrhea by RIT 4237 attenuated bovine rotavirus vaccine strain. Lancet i:977–981CrossRefGoogle Scholar
  50. Vesikari T, Isolauri, E, Delem A, D’Hondt E, Andre FE, Beards GM, Flewett TH (1985) Clinical efficacy of the RIT 4237 live attenuated bovine rotavirus vaccine in infants vaccinated before a rotavirus epidemic. J Pediatr 107:189–194PubMedCrossRefGoogle Scholar
  51. Vesikari T, Ruuska T, Delem A, Andre FE (1987a) Neonatal rotavirus vaccination with RIT 4237 bovine rotavirus vaccine: A preliminary report. Pediatr Infect Dis J 6:164–169PubMedCrossRefGoogle Scholar
  52. Vesikari T, Rautanen T, Isolauri E, Delem A, Andre FE (1987b) Immunogenuity and safety of a low passage level bovine rotavirus candidate vaccine RTT 4256 in human adults and young infants. Vaccine 5:105–108PubMedCrossRefGoogle Scholar
  53. Vodopija I, Baklaic Z, Vlatkovic R, Bogaerts H, Delem A, Andre FE (1986) Combined vaccination with live oral polio vaccine and the bovine rotavirus RIT 4237 strain. Vaccine 4:233–236PubMedCrossRefGoogle Scholar
  54. Walsh JA, Warren KS (1979) Selective primary health care: An interim strategy for disease control in developing countries. N Eng J Med 301:967–974CrossRefGoogle Scholar
  55. Ward RL, Bernstein DI, Young EC, Sherwood DI, Knowlton DR, Schiff GM (1986) Human rotavirus studies in volunteers: Determination of infections dose and serological response to infection. J Infect Dis 154:871–879PubMedCrossRefGoogle Scholar
  56. Woode GN, Jones J, Bridger JC (1975) Levels of colostral antibodies against neonatal calf diarrhea virus. Vet Rec 97:148–149PubMedCrossRefGoogle Scholar
  57. Woode GN, Kekelso NE, Simpson TF, Gaul SK, Evans LE, Babiuk L (1983) Antigenic relationships among some bovine rotaviruses: Serum neutralization and cross-protection in gnotobiotic calves. J Clin Microbiol 18:358–364PubMedGoogle Scholar
  58. Wright PF, Tajima T, Thompson J, Kokubun K, Kapikian AZ, Karzon DT (1987) Candidate rotavirus vaccine (Rhesus rotavirus strain) in children: An evaluation. Pediatrics 80:473–480PubMedGoogle Scholar
  59. Wyatt RG, Sly DL, London WT, Papmer AE, Kalica AR, van Kirk DH, Chanock RM, Kapikian AZ (1976) Induction of diarrhea in colostrum-deprived newborn Rhesus monkeys with human reovirus-like agent of infantile gastroenteritis. Arch Virol 50:17–27PubMedCrossRefGoogle Scholar
  60. Wyatt RG, Kalica AR, Mebus CA, Kim HW, London WT, Chanock RM, Kapikian AZ (1978) Reovirus like agents (Rotaviruses) associated with diarrheal illness in animals and man. In: Pollard M (ed) Perspectives in Virology, Vol 10, Raven Press, New York, p 121Google Scholar
  61. Wyatt RG, Mebus CA, Yolken RH, Kalica AR, James Jr HD, Kapikian AZ, Chanock RM (1979) Rotavirus immunity in gnotobiotic claves: Heterologous resistance to human virus induced by bovine virus. Science 203:548–550PubMedCrossRefGoogle Scholar
  62. Wyatt RG, James Jr HD, Pittman AL, Hoshino Y, Greenberg HB, Kalica AR, Flores J, Kapikian AZ (1983a) Direct isolation in cell culture of human rotaviruses and their characterization into four serotypes. J Clin Microbiol 18:310–317PubMedGoogle Scholar
  63. Wyatt RG, Kapikian AZ, Mebus CA (1983b) Induction of cross-reactive serum neutralizing antibody to human rotavirus in calves after in utero administration of bovine rotavirus. J Clin Microbiol 18:505–508PubMedGoogle Scholar
  64. Yamaguchi H, Inouye S, Yamauchi M, Monishima T, Matsuno S, Isomura S, Suzuki S (1985) Anamnestic response in fecal IgA antibody production after rotaviral infection of infants. J Infect Dis 152:398–400PubMedCrossRefGoogle Scholar
  65. Yolken RH, Wyatt RG, Zissis G, Brandt CD, Rodiguez WJ, Kim HW, Parrtto RH, Urrutia JJ, Matya L, Greenberg HB, Kapikian AZ, Chanock RM (1987a) Epidemiology of human rotavirus type 1 and 2 as studied by enzyme-linked immunosorbent assay. N Engl J Med 299:1156–1161CrossRefGoogle Scholar
  66. Yolken RH, Wyatt RG, Mata L, Urrutia RH, van Kirk DH, Dolin R, Greenberg HB, Chanock RM (1978b) Secretory antibody directed against rotavirus in human milk: Measurement by means of enzyme linked immunosorbent assay. J Pediatr 93:916–921PubMedCrossRefGoogle Scholar
  67. Zissis G, Lambert JP, Marbehant P, Marissens D, Lobmann M, Charlier P, Delem A, Zygraich N (1983) Protection studies in colostrum-deprived piglets of a bovine rotavirus vaccine candidate using human rotavirus strains for challenge. J Infect Dis 148:1061–1068PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • R. Edelman
    • 1
  • J. Flores
    • 2
  • A. Z. Kapikian
    • 2
  1. 1.Clinical and Epidemiological Studies BranchMicrobiology and Infectious Diseases ProgramBethesdaUSA
  2. 2.Laboratory of Infectious DiseasesNational Institute of Allergy and Infectious Diseases, NIHBethesdaUSA

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