Immunity to Rotaviruses
Diarrhea is the principal cause of mortality in infants and young children in the developing countries of Asia, Africa, and Latin America where the syndrome accounts annually for 3–5 billion cases and approximately 5–10 million deaths (Institute of Medicine 1985; Walsh and Warren 1979). Another estimate which reviewed data from several longitudinal studies in children revealed that 4.6 million diarrhea deaths and 744 million to 1 billion episodes of diarrhea occurred in children less than 5 years of age in developing countries, excluding China (Snyder and Merson 1982). In developed countries diarrheal deaths occur infrequently but morbidity from diarrheal illness is high (Institute of Medicine 1986; Rodriguez et al. 1987).
KeywordsOral Polio Vaccine Diarrheal Illness Heterotypic Immunity
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