Immunity to Rotaviruses

  • R. Edelman
  • J. Flores
  • A. Z. Kapikian
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 146)


Diarrhea is the principal cause of mortality in infants and young children in the developing countries of Asia, Africa, and Latin America where the syndrome accounts annually for 3–5 billion cases and approximately 5–10 million deaths (Institute of Medicine 1985; Walsh and Warren 1979). Another estimate which reviewed data from several longitudinal studies in children revealed that 4.6 million diarrhea deaths and 744 million to 1 billion episodes of diarrhea occurred in children less than 5 years of age in developing countries, excluding China (Snyder and Merson 1982). In developed countries diarrheal deaths occur infrequently but morbidity from diarrheal illness is high (Institute of Medicine 1986; Rodriguez et al. 1987).


Oral Polio Vaccine Diarrheal Illness Heterotypic Immunity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • R. Edelman
    • 1
  • J. Flores
    • 2
  • A. Z. Kapikian
    • 2
  1. 1.Clinical and Epidemiological Studies BranchMicrobiology and Infectious Diseases ProgramBethesdaUSA
  2. 2.Laboratory of Infectious DiseasesNational Institute of Allergy and Infectious Diseases, NIHBethesdaUSA

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