Abstract
Influenza virus periodically causes epidemics in humans and animals. Therefore, immunization against influenza is of considerable importance. Injection with influenza virus in humans results in the appearance of antibodies to hemagglutinin (HA) and neuraminidase in both serum and nasal secretions (Couch and Kasel 1983; Murphy et al. 1982; Shvartsman and Zykov 1976; Waldman et al. 1968). Although serum antibodies can be correlated with protection against the virus, the presence of secretory antibodies, especially those of the IgA isotype, in secretions of the upper respiratory tract, is thought to be a major determinant of immunity (Bergmann et al. 1982a; Burlington et al. 1983; Clements et al. 1983; Clements and Murphy 1986; Couch and Kasel 1983; Murphy et al. 1981, 1982; Shvartsman and Zykov 1976; Wright et al. 1983).
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© 1989 Springer-Verlag Berlin · Heidelberg
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Moldoveanu, Z. et al. (1989). Immune Responses to Influenza Virus in Orally and Systemically Immunized Mice. In: Mestecky, J., McGhee, J.R. (eds) New Strategies for Oral Immunization. Current Topics in Microbiology and Immunology, vol 146. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74529-4_10
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DOI: https://doi.org/10.1007/978-3-642-74529-4_10
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