Mobile Genetic Elements and Quantitative Characters in Drosophila: Fast Heritable Changes Under Temperature Treatment

  • V. A. Ratner
  • L. A. Vasilyeva


In 1928, when analysing the phenotypical expression of the mutation venae transversae incompletae (vti), which causes interruption or disappearance of a radial wing vein in Drosophila funebris, N.V. Timofeeff-Ressovsky showed that a change in the temperature regime at different stages of pupal ontogenesis can make this mutation change rapidly in penetrance and expressivity. The author stated that there exist at least two temperature-sensitive periods, during early, pupal stages (L1 or L2), at which a rapid change in temperature may affect in the strongest manner the phenotypical expression of a character in the individuals subjected to this treatment. In his studies, Timofeeff-Ressovsky did not investigate how a change of the character would behave in further generations and he just stopped at the phenogenetic description of the phenomenon.


Mobile Element Mobile Genetic Element Quantitative Character Distal Fragment Proximal Fragment 
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  1. Ananyev EV (1984) Molecular Cytogenetics of Mobile Genetic Elements of Drosophila melanogaster. Itogi nauki i tehniki, ser. Molekularnaya biologia v.20 VINITI-Press Moscow 65–100 (Abstract)Google Scholar
  2. Biemont C, Terzian C (1988) Mdg-1 mobile element polymorphism in selected Drosophila melanogaster populations. Genetica 76: 7–14PubMedCrossRefGoogle Scholar
  3. Bucheton A (1978) Non-Mendelian female sterility in Drosophila melanogaster: influence of ageing and thermal treatment. I. Evidence for a partly inheritable effects of these two factors. Heredity 43: 357–369CrossRefGoogle Scholar
  4. Bucheton A (1979) Non-Mendelian female sterility in Drosophila melanogaster: influence of ageing and thermal treatment. II. Action of thermal treatment on the sterility of SF females and on the reactivity of reactive females. Biologie Cellulaire 34: 43–50Google Scholar
  5. Bucheton A, Picard G (1978) Non-Mendelian female sterility in Drosophila melanogaster: hereditary transmission of reactive levels. Heredity 40: 207–223CrossRefGoogle Scholar
  6. Bucheton A, Lavige JM, Picard G, L’Heritier Ph (1976) Non-Mendelian female sterility in Drosophila melanogaster: quantitative variations in the efficience of inducer and reactive strains. Heredity 36: 305–314PubMedCrossRefGoogle Scholar
  7. Crow JF, Kimura M (1970) An introduction to population genetics theory. Harper & Row, Pub. New YorkGoogle Scholar
  8. Georgiev GP, Gvozdev VA (1980) Mobile dispersed genes of eucariotes. Vestn AN SSSR 8: 19–27 (Russian)Google Scholar
  9. Gerasimova TI, Mizrokhi LY, Georgiev GP (1984) Transposition bursts in genetically unstable Drosophila melanogaster. Nature 309: 714–716CrossRefGoogle Scholar
  10. Gvozdev VA, Belyaeva ESp, Ilyin IV, Amosova IS, Kaidanov LZ (1981) Selection and transposition of mobile dispersed genes in Drosophila melanogaater. Cold Spring Harbor Symp Quant Biol 45: 673–686PubMedGoogle Scholar
  11. Gvozdev VA, Kaidanov LZ (1986) Genome variability induced by mobile element transposition, and fitness of Drosophila melanogaster individuals. Jurn Obschey Biologii 47: 51–63 (Russian)Google Scholar
  12. Ilyin YV, Arkhipova IR, Gorelova GV, Shuppe NG (1985) Discovery of intermediates of reverse transcription of RNAs of mobile dispersed genes mdg-1 and mdg-3 in Drosophila cells. Molekularnaya biologia 19: 162–172 (Russian)Google Scholar
  13. Junakovic N, Angelucci V (1986) Polymorphism in the genomic distribution of copia-like elements in related laboratory stocks of Drosophila melanogaster. J Mol Evol 24 I:83–88CrossRefGoogle Scholar
  14. Junakovic N, Di Franco C, Barsanti P, Palumbo G (1986) Transposition of copia-likenomadic elements can be induced by heat shock. J Mol Evol 24 I:89–93CrossRefGoogle Scholar
  15. Kapitonov VV, Kolchanov NA, Shakhmuradov IA, Solovyev VV (1987) Presence of regions homologous to regulatory sites of heat shock in mobile elements. Genetika 23: 2112–2119 (Russian)PubMedGoogle Scholar
  16. Khesin RB (1984) Inconstancy of genome. Nauka Publs Moscow 578 (Abstract)Google Scholar
  17. Khouri G, Gruss P (1983) Enhancer elements. Cell 33: 313–314CrossRefGoogle Scholar
  18. Khristolyubova NB, Auslender JE (1967) Properties of inheritance of functional changes of Drosophila salivary gland chromosomes. Genetika 2: 76–79 (Russian)Google Scholar
  19. Lindsley DL, Grell EH. (1967) Genetic variations of Drosophila melanogaster. Carnegie Institution of Washington Publication No. 627Google Scholar
  20. Mackay TFC (1985) Transposable element-induced response to artificial selection in Drosophila melanogaster. Genetics 111: 351–374PubMedGoogle Scholar
  21. Mackay TFC (1988) Transposable element-induced quantitative genetic variation in Drosophila. In: Weir ES, Eisen EJ, Goodman MM, Namkoong GE (eds) The 2nd International Conference on Quantitative. Sunderland Sinauer, pp 219–235Google Scholar
  22. Maniatis T, Goodbourn S, Fisher JA (1987) Regulation of inducible and tissue-specific gene expression. Science 236: 1237–1245PubMedCrossRefGoogle Scholar
  23. McDonald JF, Strand DJ, Lambert ME, Weinstein IB (1987) The responsible genome: evidence and evolutionary implications. In: Raff RA, Raff EC, Liss AR (eds) Development as an evolutionary process. New York, pp 239–263Google Scholar
  24. Mizrokhi LY, Pryjmyagi AF, Ilyin YV, Gerasimova TI, Georgiev GP (1985) Molecular mechanism of transpositional memory in system of mdg-,4 cut locus of Drosophila melanogaster. Dokl AN SSSR 285: 1458–1460 (Russian)Google Scholar
  25. Mossie KG, Young MW, Varmus HE (1985) Extrachromosomal DNA forms of copia-like transposable elements, F-elements and middle repetitive DNA sequences in Drosophila melanogaster. J Mol Biol 182: 31–43CrossRefGoogle Scholar
  26. Neel GV (1940) The interpretation of temperature, body size and character expression on Drosophila melanogaster. Genetics 25: 225–250PubMedGoogle Scholar
  27. Pasyukova EG, Belyaeva ES, Kogan GL, Pavlova MV, Kaidanov LZ, Gvozdev VA (1986) Concerted transpositions of mobile genetic elements coupled with fitness changes in Drosophila melanogaster. Mol Biol Evol 3: 299–312PubMedGoogle Scholar
  28. Ratner VA, Vasilyeva LA (1987) Quantitative character in Drosophila: genetic, ontogenetic, cytogenetic and population aspects. Genetika 23: 1070–1081 (Russian)Google Scholar
  29. Ratner VA, Zharkikh AA, Kolchanov MA, Rodin FN, Solovyov BB, Shamim BB (1985) Problems of the theory of molecular evolution. Nauka Publ. Novosibirsk (Russian)Google Scholar
  30. Rubin GM (1983) Dispersed repetitive DNAs in Drosophila. In: Schapiro JNI (ed) Mobile genetic elements. Acad Press, pp 329–361Google Scholar
  31. Shakhmuradov IA, Kolchanov NA, Solovyev VV, Ratner VA (1986) Enhancer-like structures in moderately repeating sequences of eucaryotic genomes. Genetika 22: 347–367 (Russian)Google Scholar
  32. Shrimpton AE, Mackay TFC, Brown AJL (1987) A molecular genetic analysis of the response to selection for bristle number in Drosophila. In “Abstr of 2nd International Conference on Quantitative Genetics” Raleigh 102Google Scholar
  33. Sneath PHA, Sokal RR (1973) Numerical Taxonomy. The Principles and Practice of Numerical Classification. Freeman & Co San FranciscoGoogle Scholar
  34. Strand DJ, McDonald JF (1985) Copia is transcriptionally responsive to environmental stress. Nucl Acids Res 13: 4401–4410PubMedCrossRefGoogle Scholar
  35. Scetlov PG (1962) The problem of pathogenesis ofhereditary and non-hereditary defects of normal development in the ligth of general laws of ontogenesis. Vestnik AN SSSR 11: 13–18 (Russian)Google Scholar
  36. Svetlov PG, Korsakova GF (1962) Dependence of the wing size of vestigial mutants of Drosophila melanogaster on temperature conditions of development on the larval and proembryonal stages of ontogenesis. Doklady AN SSSR 145: 922–925 (Russian)Google Scholar
  37. Svetlov PG, Korsakova GF (1965) About dependence of characters of forked mutation at descendants of females of Drosophila melanogaster on temperature treatments. Doklady AN SSSR 165: 214–216 (Russian)Google Scholar
  38. Svetlov PG, Korsakova GF (1966 a) Influence of short heating of females of Drosophila melanogaster with forked mutation on expressivity of character of this mutation at the range of consequent generations. Doklady AN SSSR 168: 191–194 (Russian)Google Scholar
  39. Svetlov PG, Korsakova GF (1966 b) Prolonged modifications in the experiments with temperature treatments on larvae of forked mutants of Drosophila melanogaster. Doklady AN SSSR 170: 439–442 (Russian)Google Scholar
  40. Svetlov PG, Korsakova GF (1972) Inheritance of expressivity changes of eyeless mutation in Drosophila melanogaster induced by temperature treatment at special periods of development. Ontogenez 2: 347–355 (Russian)Google Scholar
  41. Tarasoff M, Suzuki DT (1970) Temperature-sensitive mutations in Drosophila melanogaster. VI. Temperature effects on development of sex-linked recessive lethals. Devel Biol 23 (3): 492–509CrossRefGoogle Scholar
  42. Thoday JM, Thompson JN Jr (1976) The number of segregation genes implied by continuous variation. Genetics 45 (3): 335–344Google Scholar
  43. Timofeef-Ressovsky NV (1928) The influence of temperature on formation of venae transversae of the wing in one genovariation of Drosophila funebria. Jurn Experim Biologii ser A 4: 199–214 (Russian)Google Scholar
  44. Vasilyeva LA, Zabanov SA, Ratner VA (1985) On the possible role of Mobile Genetic Elements ( MGE) in determination and evolution of quantitative character. In Internat Sympos `Biological Evolution“ Bary (Italy) 84–86Google Scholar
  45. Vasilyeva LA, Ratner VA, Zabanov SA (1987 a) Expression of quantitative character radius incompletus,temperature effects and localization of mobile elements in Drosophila. I. Properties of investigated populations. Genetika 23: 71–80 (Russian)Google Scholar
  46. Vasilyeva LA, Zabanov SA, Ratner VA, Zhimulev IF, Protopopov MO, Belyaeva ES (1987 b) Expression of quantitative character radius incompletus,temperature effects and localization of mobile elements in Drosophila. II. Mobile genetic elements Dm-412. Genetika 23: 81–92 (Russian)Google Scholar
  47. Vasilyeva LA, Zabanov SA, Ratner VA, Zhimulev IF, Protopopov MO, Belyaeva ES (1988) Expression of a quantitative character radius incompletus, temperature effects and localization of the mobile genetic elements Dm-412 in Drosophila melanogaster. Gen Sel Evol 20 (2): 65–85CrossRefGoogle Scholar
  48. Zabanov SA, Vasilyeva LA, Ratner VA (1989) Expression of quantitative character radius incompletus,temperature effects and localization of mobile elements in Drosophila. III. Mobile genetic elements mdg-1 and copia. Genetika 25 (in press) (Russian).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • V. A. Ratner
    • 1
  • L. A. Vasilyeva
    • 1
  1. 1.Institute of Cytology and GeneticsNovosibirskUSSR

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