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Aktuelle Neuropädiatrie 1988 pp 35–46Cite as

Pathophysiologische Aspekte der Migräne

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Zusammenfassung

Die vielfältigen Hypothesen zur Migräne (Amery 1984; Bakal 1975; Bes et al. 1986; Biggs u. Johnson 1984; Berde u. Fanchamps 1975; Bruyn 1984; Heyck 1982; Sargent et al. 1973; Saxena 1978; Wolff 1980) ergeben ein komplexes Bild der möglichen Pathophysiologie einer oder „der“ Migräne. Eine Entscheidung bezüglich der Wertigkeit nachgewiesener Störungen im Rahmen der Pathophysiologie erscheint zunächst nicht möglich. Es stellt sich aus klinischer Sicht daher die Frage, ob die gemeine, die klassische Migräne und die „migraine accompagnée“ unterschiedliche Krankheitsbilder darstellen (Hatchinski 1985; Olesen 1981b; Dalessio 1985; Wilkinson u. Blau 1985) oder ob sie als klinischer Ausdruck unterschiedlich schwerer Störungen bei einer im Grunde einheitlichen Pathophysiologie aufzufassen sind (Heyck 1956; Wolff 1980).

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Literatur

  • Akkermann JWN, Verhoeven JM (1986) Energy metabolism and function. In: Hornsen H (ed) Platelet responses and metabolisms, vol III. CRC Press, Florida, p 69

    Google Scholar 

  • Amery WK (1984) Cerebral hypoxia and migraine. In: Amery WK, Van Nueten JM, Wauquir A (eds) The pharmacological basis of migraine therapy. Pitman, London, p 118

    Google Scholar 

  • Anthony M, Hinterberger H, Lance JW (1969) The possible relationship of serotonin in the migraine syndrom. Res Clin Stud Headache 2: 29

    CAS  Google Scholar 

  • Auer LM (1986) Sympathetic control of pial vessels under in vivo conditions. In: Owman C, Hardebo JE (eds) Neural regulation of brain circulation. Elsevier, New York, p 497

    Google Scholar 

  • Bakal DA (1975) Headache: A biopsychological perspective. Psycholog Bull 82 (3): 369

    Article  CAS  Google Scholar 

  • Baumbach GL, Heistad DD (1983) Effects of sympathetic stimulation and changes in arterial pressure on segmental resistance of cerebral vessels in rabbits and cats. Circ Res 52: 527

    PubMed  CAS  Google Scholar 

  • Baumbach G, Busija D, Werber A, Heistad D (1984) Role of autonomic innervation in modifi-cation of cerebral vascular responses. In: MacKenzie ET et al. (eds) L.E.R.S., vol 2. Raven, New York, p 53

    Google Scholar 

  • Baumbach GL, Mayhan WG, Heistad DD (1986) Protective effects of sympathetic nerves during hypertension. In: Owman C, Hardebo JE (eds) Neural regulation of brain circulation. Elsevier, New York, p 607

    Google Scholar 

  • Berde B, Fanchamps A (1975) Bedeutung humoraler Mediatoren für Pathogenese und Behandlung der Migräne. MMW 117: 1489

    CAS  Google Scholar 

  • Bes A et al. (1986) Dopamin and migraine. In: MacKenzie ET et al. (eds) L.E.R.S., vol 2. Raven, New York, p 157

    Google Scholar 

  • Biggs MJ, Johnson ES (1984) The autonomic nervous system and migraine pathogenesis. In: Amery WK, Van Nueten JM, Wauquier A (eds) The pharmacological basis of migraine therapy. Pitman, London, p 99

    Google Scholar 

  • Bille B (1982) Migraine in children and its prognosis. Cephalalgia 1 (2): 71

    Article  Google Scholar 

  • Brune K (1980) Periphere Wirkung von Analgetika — Implikationen für die Schmerztherapie. In: Kocher R, Gross D, Kaeser HE (Hrsg) Nacken-Schulter-Arm-Syndrom. G. Fischer, Stuttgart

    Google Scholar 

  • Bruyn GW (1982) Cerebral cortex and migraine. In: Critchley M et al. (eds) Advances in neurology, vol 33. Raven Press, New York, p 151

    Google Scholar 

  • Bruyn GW (1984) The pathomechanism of migraine as basis for pharmacotherapy — A clinician’s epilogue. In: Amery WK, Van Nueten JM, Wauquier A (eds) The pharmacological basis of migraine therapy. Pitman, London, p 297

    Google Scholar 

  • Busija DW, Heistad DD (1984) Effects of unilateral and bilateral activation of sympathetic nerves on cerebral blood flow during hypercapnia. J Physiol (Lond) 347: 35

    CAS  Google Scholar 

  • Butinelli C, Lazarro MP, Lenzi GL, Paolucci ST, Principe M (1985) Correlation between migraine and circulation platelet aggregates. Cephalalgia 2: 87

    Google Scholar 

  • Couch JR, Hassanein RS (1976) Platelet hyperaggregability in migraine and relation of aggregability to clinical aspects of migraine. Neurology 26: 348

    Google Scholar 

  • Couch JR, Hassanein RS (1977) Platelet hyperaggregability in migraine. Neurology 27: 843

    PubMed  CAS  Google Scholar 

  • Dalessio DJ (1976) The relationship of vasoactive substances to vascular permeability and their role in migraine. Res Clin Stud Headache 4: 76

    PubMed  CAS  Google Scholar 

  • Dalessio DJ (1985) Is there a difference between classic and common migraine? Arch Neurol 42: 275

    PubMed  CAS  Google Scholar 

  • Deshmukh VD, Harper AM (1971) Effect of serotonin on cerebral blood flow and external carotid artery in the baboon. In: Rüssel RWR (ed) Brain and blood flow. Pitman, London, p 136

    Google Scholar 

  • Dougherty JH, Levy ED, Weksler BB (1981) Gesteigerte Blutplättchenfunktion bei cerebraler Ischämie. In: Breddin HK, Loew K, Überla K, Dorndorf W, Marx R (eds) Prophylaxe venöser, peripherer, kardialer und zerebraler Gefäßkrankheiten mit Acetylsalicylsäure. Schattauer, Stuttgart, p 143

    Google Scholar 

  • Edmeads J (1977) Cerebral blood flow in migraine. Headache 17: 148

    Article  PubMed  CAS  Google Scholar 

  • Edvinsson L, Degeurce A, Duverger D, MacKenzie ET, Scratton B, Uddman R (1983) Coubling between cerebral blood flow and metabolism. A role for serotonin. In: MacKenzie ET et al. (ed) L.E.R.S., vol 2. Raven, New York, p 121

    Google Scholar 

  • Engineer DM, Niederhauser U, Pieper PJ, Sirois P (1978) Release of mediators of anaphylaxis: Inhibition of prostaglandin synthesis and the inhibition of release of slow reacting substance of anaphylaxis and histamine. Br J Pharmacol 62: 61

    PubMed  CAS  Google Scholar 

  • Fronek K, Zwiefach BW (1975) Microvascular pressure distribution in skeletal muscle and effect of vasodilatation. Am J Physiol 228: 791

    PubMed  CAS  Google Scholar 

  • Gawel M, Burkitt M, Rose FC (1979) The platelet release reaction during migraine attacks. Headache 19: 323

    Article  PubMed  CAS  Google Scholar 

  • Gerber WD (1986) Verhaltensmedizin der Migräne. In: Dahme B, Koch U, Pöppel E (Hrsg) Psychologie der Medizin. Edition Medizin, VCH, Weinheim

    Google Scholar 

  • Gerber WD, Diener HC, Scholz E (1987) Migräne in Forschung und Praxis. Edition Medizin, VCH, Weinheim, p 13

    Google Scholar 

  • Granström E (1983) Biochemistry of prostaglandins thromboxanes and leucotrienes. In: Bonica J et al. (eds) Advances in pain research and therapy, vol 5. Raven Press, New York

    Google Scholar 

  • Grimson BS, Robinson SC, Danford EI, Tindali GT, Greefield JC jr (1969) Effect of serotonin in internal and external carotid artery blood flow in the baboon. Am J Physiol 216: 55

    Google Scholar 

  • Grotemeyer KH (1988) Thrombozytenfunktion bei neurologischen Erkrankungen. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Grotemeyer KH, Brune GG (1988a) Die Pathophysiologic der Migräne. In: Soyka D (Hrsg) Chronische Kopfschmerzen. Fischer, Stuttgart

    Google Scholar 

  • Grotemeyer KH, Brune GG (1988b) Klinik und Differentialdiagnose des idiopathischen Kopfschmerzes. In: Grotemeyer KH, Brune GG (Hrsg) Der Migränekopfschmerz. Arcis, München

    Google Scholar 

  • Grotemeyer KH, Husstedt IW, Schlake HP (1988) Platelet-function under migraine prophylaxis with metoprolol and flunarizin. Neurology 235: S74

    Google Scholar 

  • Grotemeyer KH, Viand R, Beykirch K (1983) Thrombozytenfunktion bei vasomotorischem Kopfschmerz und Migränekopfschmerz. Dtsch Med Wochenschr 108: 775

    Article  PubMed  CAS  Google Scholar 

  • Grotemeyer KH, Viand R, Beykirch K (1984) Klinische und laborchemische Ergebnisse zur Prophylaxe der Migräne mit Azetylsalizylsäure. Med Welt 35: 762

    Google Scholar 

  • Hannington E, Jones RJ, Amess JAL, Wachowitz B (1981) Migraine: A platelet disorder. Lancet 11: 720

    Article  Google Scholar 

  • Harper AM, McKenzie ET (1977) Effects of 5-hydroxytryptamin on pial arteriolar calibre in anaesthetisized cats. J Am Physiol 271: 735

    CAS  Google Scholar 

  • Hatchinski V (1985) Common and classic migraine — one or two entities? Arch Neurol 42: 277

    Google Scholar 

  • Heiss WD, Beil C, Herholz K, Pawik G, Wagner R, Wienhard K (1985) Atlas der Positronen-Emissions-Tomographie des Gehirns. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Heyck H (1956) Neue Beiträge zur Klinik und Pathogenese der Migräne. Thieme, Stuttgart

    Google Scholar 

  • Heyck H (1982) Der Kopfschmerz, 5. Aufl. Thieme, Stuttgart

    Google Scholar 

  • Itakura T (1986) Aminergic innervation of the cerebral veins shown by catecholamine histofluorescence, DBH immunohistochemistry, and electron microscopy. In: Owman C, Hardebo JE (eds) Neural regulation of brain circulation. Elsevier, New York, p 451

    Google Scholar 

  • Jones RJ, Forsyte AM, Amess JAL (1982) Platelet aggregation in migraine patients during headache free intervall. In: Critchley M, Friedman AP, Gorini S, Sicuteri F (eds) Advances in neurology, vol 33. Raven, New York, p 275

    Google Scholar 

  • Kelly PAT (1984) GABAergic influences on cerebral tissue perfusion. In: MacKenzie et al. (eds) L.E.R.S., vol 2. Raven, New York, p 175

    Google Scholar 

  • Knapp TW (1983) Migräne. I: Symptomatologie und Ätiologie. Beltz, Weinheim

    Google Scholar 

  • Kontos HA, Wei EP, Navari RM, Levasseur JE, Rosenblum WI, Patterson JL (1978) Responses of cerebral arteries and arterioles to acute hypotension and hypertension. Am J Physiol 234: H371–H383

    PubMed  CAS  Google Scholar 

  • Lance JW, Spira PJ, Lord GDA, Duckworth JW (1978) Evaluation of drugs applicable to treatment of migraine in cranial circulation of the monkey. Res Clin Stud Headache 21: 13

    Google Scholar 

  • Lauritzen M, Olsen J (1984) Regional cerebral blood flow during migraine attacks by Xenon-133 inhalation and emission tomography. Brain 107: 447

    Article  PubMed  Google Scholar 

  • Lauritzen M, Skyhoj Olsen T, Lassen NA, Paulson OB (1983) The regulation of regional cerebral blood flow during and between migraine attacks. Ann Neurol 14: 569

    Article  PubMed  CAS  Google Scholar 

  • Lee TJF (1986) Sympathetic and nonsympathetic transmitter mechanisms in cerebral vasodilation and constriction. In: Owman C, Hardebo JE (eds) Neural regulation of brain circulation. Elsevier, New York, p 285

    Google Scholar 

  • Lima DR, Turner P (1983) Propanolol increases reduced beta-receptor function in severely anxious patients. Lancet 11: 444

    Google Scholar 

  • Lübbers DW (1972) Physiologie der Gehirndurchblutung. In: Gänshirt H (Hrsg) Der Hirnkreislauf. Thieme, Stuttgart, S 214

    Google Scholar 

  • Marcus AJ (1978) The role of lipids in platelet function: With particular reference to the arachidonic acid pathway. J Lipid Res 19: 793

    PubMed  CAS  Google Scholar 

  • Marshall J (1978) Cerebral blood flow in migraine. In: Greene R (ed) Concepts in migraine research. Raven, New York, p 131

    Google Scholar 

  • Mathew NT, Harstink F, Meyer JS (1976) Regional cerebral blood flow in the diagnosis of vascular headache. Headache 15: 252

    Article  PubMed  CAS  Google Scholar 

  • McCulloch J (1984) Role of dopamine in interactions among cerebral function, metabolism, and blood flow. In: MacKenzie et al. (eds) L.E.R.S., vol 2. Raven, New York, p 137

    Google Scholar 

  • Mena MA, Vidrio H (1979) Reversal of serotonin vasodilatation in the dog external carotid bed by sympathetic denervation. J Cardiovasc Pharmacol 1: 149

    Article  PubMed  CAS  Google Scholar 

  • Mück-Seler D, Deanovic Z, Dupelj M (1982) Serotonin releasing factors in migrainous patients. In: Critchley M (ed) Advances in neurology, vol 33. Raven, New York, pp 257

    Google Scholar 

  • Mumenthaler M (1986) Neurologie. Thieme, Stuttgart, S 64

    Google Scholar 

  • Nortis JW, Hachinski VC, Cooper PW (1975) Changes in cerebral blood flow during a migraine attack. Br Med J III: 676

    Google Scholar 

  • Nylin G, Hedlund S, Regnström O (1961) Studies of cerebral circulation with labelled erythrozytes in healthy man. Circ Res 9: 664

    PubMed  CAS  Google Scholar 

  • O’Brian MD (1971) Cerebral blood changes in migraine. Headache 10: 139

    Article  Google Scholar 

  • Olesen J (1978) Some clinical features of the acute migraine attack, an analysis of 750 patients. Headache 18: 266

    Article  Google Scholar 

  • Olesen J (1987) Migraine and regional cerebral blood flow. Trends Neurosci 8: 318

    Article  Google Scholar 

  • Olesen J, Larsen B, Lauritzen M (1981b) Focal hyperemia followed by spreading oligema and impaired activation of rCBF in classic migraine. Ann Neurol 9: 344

    Article  PubMed  CAS  Google Scholar 

  • Olesen J, Lauritzen M, Tfelt-Hansen P, Hendriksen L, Larsen B (1982) Spreading cerebral oligemia in classical and normal cerebral blood flow in common migraine. Headache 22: 242

    Article  PubMed  CAS  Google Scholar 

  • Olesen J, Tfelt-Hansen P, Hendriksen L, Larsen B (1981a) The common migraine attack may not be initiated by cerebral ischaemia. Lancet 11: 438

    Article  Google Scholar 

  • Olsen TS, Friberg L, Lassen NA (1987) Ischemia may be the primary cause of neurologic deficits in classic migraine. Arch Neurol 44: 156

    Google Scholar 

  • Owman C, Andersson J, Hanko J, Hardobo JE (1984) Neurotransmitter amines and peptides in the cerebrovascular bed. In: MacKenzie ET et al. (eds) L. E. R. S., vol 2. Raven, New York, p 11

    Google Scholar 

  • Peters JR, Elliot JM, Graham-Smith DG (1980) The effect of oral contraceptives on platelet noradrenaline and 5-hydroxytryptamine receptors and aggregation. In: Turner P (ed) Clinical pharmacology and therapeutics. Macmillan, London, p 165

    Google Scholar 

  • Pletscher A, Laubscher A (1980) Use and limitations of platelets as models for neurons: Amine release and shape change reaction. In: Rotman A, Meyer FA, Gitler C, Silberberg A (eds) Platelets cellular response mechanisms and their biological significance. Wiley & Sons, New York Chichester, p 267

    Google Scholar 

  • Reis DJ (1984) Central neural control of circulation and metabolism. In. MacKenzie ET et al. (eds) L.E.R.S., vol 2. Raven, New York, p 91

    Google Scholar 

  • Rolf LH, Schlake HP, Brune GG (1983) Plasmafaktoren und Migräne. In: Soyka D (Hrsg) Migräne. Enke, Stuttgart, S 79

    Google Scholar 

  • Sakai F, Meyer JS (1978) Regional cerebral hemodynamics during migraine and cluster headache measured by the 133-Xe inhalation method. Headache 18: 122

    Article  PubMed  CAS  Google Scholar 

  • Sakai F, Meyer JS (1979) Abnormal cerebrovascular reactivity in patients with migraine and cluster headache. Headache 19: 257

    Article  PubMed  CAS  Google Scholar 

  • Sargent JD, Walters ED, Green EE (1973) Psychosomatic self-regulation of migraine headaches. Semin Psychiatry 5 (4): 415

    PubMed  CAS  Google Scholar 

  • Saxena PR (1972) The effects of antimigraine drugs on the vascular responses by 5-hydroxytryptamine and related biogenic substances on external carotid bed of dogs: Possible pharmacological implications to their antimigraine action. Headache 12: 44

    Article  PubMed  CAS  Google Scholar 

  • Saxena PR (1978) Arteriovenous shunting and migraine. Res Clin Stud Headache 6: 89

    PubMed  CAS  Google Scholar 

  • Saxena PR, de Vlaam-Schluter GM (1974) Role of some biogenic substances in migraine and relevant mechanism in antimigraine action of ergotamine studies in an experimental model for migraine. Headache 13: 142

    CAS  Google Scholar 

  • Schlake HP, Grotemeyer KH, Böttger I, Husstedt IW, Brune GG (1987) 123J-Amphetamine-SPECT in classical migraine and migraine accompagnee. Neurosurg Rev 10: 191

    Google Scholar 

  • Schneider W, Reimers HJ, Morgenstern E (1978) Thrombozytenstoffwechsel. In: Breddin HK (Hrsg) Prostaglandine und Plättchenfunktion. Schattauer, Stuttgart, S 19

    Google Scholar 

  • Sercombe R, Verrecchia C (1986) Role of vascular endothelium in modulating cerebrovascular effects of neurotransmitters. In: Ownman C, Hardebo JF (eds) Neural regulation of brain circulation. Elsevier, Amsterdam, p 27

    Google Scholar 

  • Sercombe R, Lacombe P, Seylaz J (1984) Functional significance on the cerebrovascular reactivity to autonomic neurotransmitters. In: MacKenzie ET et al. (eds) L.E.R.S., vol 2. Raven, New York, p 65

    Google Scholar 

  • Simrad D, Pauson OB (1973) Cerebral vasomotor paralysis during migraine attack. Arch Neurol 29: 207

    Google Scholar 

  • Silverberg GD (1986) Noradrenergic perivascular nerve control of the cerebral circulation. In: Owman C, Hardebo JF (eds) Neural regulation of brain circulation. Elsevier, New York, p 273

    Google Scholar 

  • Skinhoj E (1973) Hemodynamic studies within the brain during migraine. Arch Neurol 29: 95

    PubMed  CAS  Google Scholar 

  • Skinhoj E, Paulson OB (1969) Regional cerebral blood flow and internal carotid distribution during migraine attack. Br Med J III: 569

    Article  Google Scholar 

  • Soyka D (1984) Kopfschmerz. In: Neuendoerfer B, Schimrigk K, Soyka D (Hrsg) Praktische Neurologie. Edition Medizin, Weinheim

    Google Scholar 

  • Spira PJ, Mylecharane EJ, Misbach J, Duckworth JW, Lance JW (1978) Internal and external carotid vascular responses to vasoactive agents in monkey. Neurology 28: 162

    PubMed  CAS  Google Scholar 

  • Turner P (1984) Beta-blocking drugs in migraine. Postgrad Med J 60 (2): 51

    PubMed  Google Scholar 

  • Vanhoutte PM (1978) Heterogeneity in vascular smooth muscle. In: Kaley G, Altura BM (eds) Microcirculation, vol II. Univ. Press, Baltimore, p 181

    Google Scholar 

  • Vanhoutte PM, Cohen RA (1983) The elusory role of serotonin in vascular function and disease. Biochem Pharmacol 32 (24): 3671

    Article  PubMed  CAS  Google Scholar 

  • Vidrio H, Hong E (1976) Vascular tone and reactivity to serotonin in the internal and external carotid vascular beds of the dog. J Pharmacol Exp Ther 197: 49

    PubMed  CAS  Google Scholar 

  • White JG (1984) The ultrastructure and regulatory mechanism of blood platelets. In: Lasslo A (ed) Blood platelet function and medical chemistry, 15

    Google Scholar 

  • Wilkinson M (1986) Clinical features of migraine. In: Clifford Rose F (ed) Handbook of clinical neurology, vol 4 (48): 117

    Google Scholar 

  • Wilkinson M, Blau JN (1985) Are classical and common migraine different entities? Headache 29: 211

    Article  Google Scholar 

  • Wolff HG (1980) Wolff’s headache and other head pain. Oxford Univ. Press, Oxford

    Google Scholar 

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Authors
  1. K.-H. Grotemeyer
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  2. I. W. Husstedt
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  3. H. P. Schlake
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  1. Kinderklinik und -Poliklinik der Technischen Universität, Kölner Platz 1, D-8000, München 40, Germany

    Hans-Martin Weinmann

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Grotemeyer, KH., Husstedt, I.W., Schlake, H.P. (1989). Pathophysiologische Aspekte der Migräne. In: Weinmann, HM. (eds) Aktuelle Neuropädiatrie 1988. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74499-0_4

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