Abstract
This paper reviews current applications of mieroprobe analysis in medicine with emphasis on medical practice as opposed to research applications. In current medical practice, mieroprobe analysis is usually accomplished on an electron microscope (EM) equipped with an energy dispersive x-ray detector (EDX). Accordingly, electron probe microanalysis (EPMA) is emphasized in this communication. However, newer technologies such as ion and laser microscopes are now being used in a few laboratories for medical studies; therefore these will be briefly considered as well. For more extensive discussions of all of these topics, the reader is directed to our recent publication (Ingram et al., 1989).
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References
Abraham JL, Burnett BR (1989) Quantitative in situ analysis of inorganic particulate burden in tissue sections — an update. Chapter 6 In: Ingram P, Shelburne JD, Roggli VL (eds) Microprobe analysis in medicine. Hemisphere Publishing Corporation, Washington, DC pp 111–131.
Cameron IL, Smith NKR (1989) Applications of electron probe x-ray microanalysis to the study of ionic regulation of growth in normal and cancer cells. Chapter 15 In: Ingram P, Shelburne JD, and Roggli VL (eds) op cit. pp 291-301.
Gilkey JC, Staehlin LA (1986) Advances in ultrarapid freezing for the preservation of cellular ultrastructure. J Eleetr Micros Teehn 3:177–210.
Herlong JR, LeFurgey A, Ingram P, Mandel LJ, Hawkey LA (1988) Quantitative x-ray imaging of human cystic fibrosis nasal epithelium. In: Newbury DE (Ed) Microbeam Analysis. San Francisco Press, San Francisco, pp 447–450.
Ingram P, Shelburne JD, Roggli VL (Editors) (1989) Microprobe analysis in medicine. Hemisphere Publishing Corporation, Washington, DC.
Iwanczyk JS, Dabrowski AJ, Huth GC, Bradley JG, Conley JM, Albee AL (1984) First use of a mercuric iodide (HgI2) energy dispersive x-ray detector in a scanning electron microscope. Scanning Electron Microscopy, 1:9–14.
Karas M, Hillenkamp F (1988) Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. Anal Chem 60: 2299–2301.
LeFurgey A, Bond M, Ingram P (1988) Frontiers in electron probe mieroanalysis: application to cell physiology. Ultra microscopy 24:185–220.
Leong AS-Y, Disney APS, Gove DW (1982) Spallation and migration of silicone from blood-pump tubing in patients on hemodialysis. NEJM 306:135–140.
Lechene C, Warner R (1979) Electron probe analysis of liquid droplets. In: Microbeam Analysis in Biology. Leehene C, Warner R (Eds) Academic Press, New York, pp 279–296.
Levi-Setti R, Chabala JM, Wang YL, Hallegot P (1988) High-resolution ion probe imaging and analysis. In: Newbury DE (ed) Microbeam Analysis-1988, San Francisco Press, San Francisco, pp 93–101.
Linton RW, Musselman IH, Bryan SR (1989) Laser and ion microprobe mass spectrometry — applications to human tissues. Chapter 16 In: Ingram P, Shelburne JD, and Roggli VL (eds) op cit. pp 303–333.
Menco BPM (1986) A survey of ultra-rapid cryofixation methods with-particular emphasis on applications to freeze-fracturing, freeze-etching, and freeze-substitution. J Eleetr Microsc Teehn 4:177–240.
Middleman ML, Geller JD (1976) Trace element analysis using x-ray excitation with an energy dispersive spectrometer on a scanning electron microscope. Scanning Electron Microsc I:171–179.
Quinton PM (1978) SEM-EDS x-ray analysis of fluids. Scanning Electron Microscopy 2:391–397.
Roggli VL (1989) Scanning electron microscopic analysis of mineral fibers in human lung. Chapter 5 In: Ingram P, Shelburne JD, and Roggli VL (eds) op cit. pp 97-110.
Roinel N (1988) Quantitative x-ray analysis of biological fluids: The microdroplet technique. J Electr Micros Techn 9:45–56.
Roomans GM (1988) Quantitative x-ray mieroanalysis of biological specimens. J Eleetr Micros Techn 9:19–43.
Roomans GM (1989) Cystic fibrosis. Chapter 9 In: Ingram P, Shelburne JD, and Roggli VL (eds) op cit. pp 163-175.
Shelburne JD, Tucker JA, Roggli VL, Ingram P (1989) Overview of applications in medicine. Chapter 3 In: Ingram P, Shelburne JD, and Roggli VL (eds) op cit. pp 55-77.
Wroblewski J, Wroblewski R, Roomans G (1988) Low temperature techniques for x-ray mieroanalysis in pathology: alternatives to eryoultramicrotomy. J Eleetr Micros Techn 9:83–98.
Wroblewski R, Edstrom L (1989) Disorders of skeletal muscle. Chapter 12 In: Ingram P, Shelburne JD, and Roggli VL (eds) op cit. pp 219-236.
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© 1989 Springer-Verlag Berlin Heidelberg
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Shelburne, J.D., Roggli, V.L., Ingram, P., Tucker, J.A., Linton, R.W. (1989). Microprobe Analysis in Medicine — Present Practice and Future Trends. In: Zierold, K., Hagler, H.K. (eds) Electron Probe Microanalysis. Springer Series in Biophysics, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74477-8_23
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DOI: https://doi.org/10.1007/978-3-642-74477-8_23
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