The behavior of cell surface components during cell locomotion: A quantitative approach

  • J. Lee
  • A. Ishihara
  • B. Holifield
  • K. Jacobson
Conference paper
Part of the Springer Series in Biophysics book series (BIOPHYSICS, volume 5)

Abstract

The precise mechanism of cell locomotion is poorly understood despite extensive research into this area. The main reason for this is that it is a very complex phenomenon involving many interrelated cellular events. In order to move, a cell must first adhere to the substratum and then generate enough force to drive the cell forward. In addition, sustained movement in a particular direction always requires the polarisation of cells into a ‘front’ and ‘rear’ end. Despite experimental advances and progress in understanding these events, the molecular mechanism of cell locomotion and its control remain largely unknown. The purpose of this article is to describe how the experimental approach to cell locomotion has changed and to illustrate this with examples of recent work in this area from our laboratory.

Keywords

Bleached Kelly Cytochalasin Concanavalin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • J. Lee
    • 1
  • A. Ishihara
    • 1
  • B. Holifield
    • 1
  • K. Jacobson
    • 1
  1. 1.Department of Cell Biology and AnatomyUniversity of North Carolina at Chapel HillChapel HillUSA

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