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Biophysics of the Cell Surface pp 341–361Cite as

The behavior of cell surface components during cell locomotion: A quantitative approach

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Part of the book series: Springer Series in Biophysics ((BIOPHYSICS,volume 5))

Abstract

The precise mechanism of cell locomotion is poorly understood despite extensive research into this area. The main reason for this is that it is a very complex phenomenon involving many interrelated cellular events. In order to move, a cell must first adhere to the substratum and then generate enough force to drive the cell forward. In addition, sustained movement in a particular direction always requires the polarisation of cells into a ‘front’ and ‘rear’ end. Despite experimental advances and progress in understanding these events, the molecular mechanism of cell locomotion and its control remain largely unknown. The purpose of this article is to describe how the experimental approach to cell locomotion has changed and to illustrate this with examples of recent work in this area from our laboratory.

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Author information

Author notes

  1. A. Ishihara

    Present address: MRC Cell Biophysics Unit, 26-29 Drury Lane, London, WC2B 5, RL, UK

Authors and Affiliations

  1. Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA

    J. Lee, A. Ishihara, B. Holifield & K. Jacobson

Authors
  1. J. Lee
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  2. A. Ishihara
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  3. B. Holifield
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  4. K. Jacobson
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Editor information

Editors and Affiliations

  1. Sektion Biologie Wissenschaftsbereich Biophysik, Humboldt Universität zu Berlin, Invalidenstraße 42, 1040, Berlin, DDR

    Roland Glaser Professor Dr.

  2. Department of Biology as Applied to Medicine, Middlesex Hospital Medical School, London, W1P 6DB, Great Britain

    David Gingell Professor Dr.

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© 1990 Springer-Verlag Berlin Heidelberg

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Lee, J., Ishihara, A., Holifield, B., Jacobson, K. (1990). The behavior of cell surface components during cell locomotion: A quantitative approach. In: Glaser, R., Gingell, D. (eds) Biophysics of the Cell Surface. Springer Series in Biophysics, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74471-6_17

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  • DOI: https://doi.org/10.1007/978-3-642-74471-6_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74473-0

  • Online ISBN: 978-3-642-74471-6

  • eBook Packages: Springer Book Archive

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