The behavior of cell surface components during cell locomotion: A quantitative approach
The precise mechanism of cell locomotion is poorly understood despite extensive research into this area. The main reason for this is that it is a very complex phenomenon involving many interrelated cellular events. In order to move, a cell must first adhere to the substratum and then generate enough force to drive the cell forward. In addition, sustained movement in a particular direction always requires the polarisation of cells into a ‘front’ and ‘rear’ end. Despite experimental advances and progress in understanding these events, the molecular mechanism of cell locomotion and its control remain largely unknown. The purpose of this article is to describe how the experimental approach to cell locomotion has changed and to illustrate this with examples of recent work in this area from our laboratory.
KeywordsBleached Kelly Cytochalasin Concanavalin
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