Skip to main content
SpringerLink
Log in

The Proliferation Behavior of Bone Tumors Investigated with the Monoclonal Antibody Ki-67

  • Chapter
Biological Characterization of Bone Tumors

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 80))

Abstract

Bone tumors are a rare kind of neoplasm. Their varied clinical manifestations, together with their rarity of occurrence, involve the pathologist in considerable difficulties in differentiating benign or merely reactive changes from malignant disease. Correct diagnosis of bone tumors calls for close interdisciplinary Cooperation, but even then the difficulties may be grave, and sometimes hardly surmountable in differential diagnosis. Further improvement in the prognosis of malignant osseous neoplasm — beyond the progress seen in recent years — will be achieved only by earlier recognition and greater diagnostic accuracy. Any diagnostic considerations should therefore be centered upon the recognition of the tumor type and its biological behavior.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Auböck L (1975) Zur Ultrastruktur fibröser und histiocytärer Hauttumoren (Dermatofibroma, Dermatofibrosarcoma protuberans, Fibroxanthom and Histiocytom). Virchows Archiv 368: 253–274

    Google Scholar 

  • Bouropoulou V, Kontogeorgos G, Papamichales G, Bosse A, Roessner A, Vollmer E (1987) Differential diagnosis of chordoma. Immunohistochemical aspects. Arch Anat Cytol Pathol 35: 35–40

    PubMed  CAS  Google Scholar 

  • Dahlin DC, Unni KK (1986) Bone tumors. General aspects and data on 8542 cases, 3rd edn. Charles C. Thomas, Springfield

    Google Scholar 

  • Dahlin DC, Cupps RE, Johnson EW Jr (1970) Giant cell tumors: a study of 195 cases. Cancer 25: 1061–1070

    Article  PubMed  CAS  Google Scholar 

  • Dahlin DC, Unni KK (1977) Osteosarcoma of bone and its important recognizable varieties. Am J Surg Pathol 1: 61–72

    Article  PubMed  CAS  Google Scholar 

  • Dominok GW, Knoch HG (1982) Knochengeschwülste und geschwulstähnliche Knochenerkrankungen, 3rd edn. VEB Gustav Fischer, Jena

    Google Scholar 

  • Gerdes J (1985) An immunohistological method for estimating cell growth fractions in rapid histopathological diagnosis during surgery. Int J Cancer 35: 169–171

    Article  PubMed  CAS  Google Scholar 

  • Gerdes J, Schwab U, Lembke H, Stein H (1983) Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 31: 13–20

    Article  PubMed  CAS  Google Scholar 

  • Gerdes J, Lembke H, Baisch H, Wacker HH, Schwab U, Stein H (1984) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133: 1710–1715

    PubMed  CAS  Google Scholar 

  • Gerdes J, Pileri S, Bartels H, Stein H (1986) Proliferation marker Ki-67: correlation with histological diagnosis, histological tumor grading, and prognosis. Verh Dtsch Ges Pathol 70: 152–158

    PubMed  CAS  Google Scholar 

  • Grundmann E (ed) (1976) Malignant bone tumors. Springer, Berlin Heidelberg New York (Rec Res Cancer Res, vol 54)

    Google Scholar 

  • Grundmann E, Mellin W, Roessner A, Bösing Th, Hiddemann W, Vollmer E, Edel G, Lingg G (1986) Zur Klassification und Prognose der Osteosarkome im Erfahrungsgut des Knochengeschwulstregisters Westfalen unter Einbezug proliferationskinetischer Parameter. In: Dietsch P, Keck E, Kruse HP, Kuhlencordt F (eds) Aktuelle Ergebnisse der Osteologie. W. de Gruyter, Berlin, pp 221–226

    Google Scholar 

  • Heliö H, Karaharju E, Nordling S (1985) Flow cytometric determination of DNA content in malignant and benign bone tumors. Cytometry 6: 165–171

    Article  PubMed  Google Scholar 

  • Huvos AG (1979) Bone tumors: diagnosis, treatment and prognosis. W.S. Saunders, Philadelphia

    Google Scholar 

  • Jaffe HL, Lichtenstein L, Portis RB (1940) Giant cell tumor of bone. Its pathologic appearance, grading, supposed variants and treatment. Arch Pathol. 30: 993–1031

    Google Scholar 

  • Jaffe HL (1958) Tumors and tumorous conditions of the bones and joints. Lea amp Febiger, Philadelphia

    Google Scholar 

  • Kertelge E, Roessner A, Vollmer E, Winterberg B, Tenschert W, Vetter H, Hauss J, Buchholz B (1987) Immunohistological evaluation of 36 pheochromocytomas with regard to Proteohormone secretion and proliferation. Arch Anat Cytol Pathol 35: 155–161

    PubMed  CAS  Google Scholar 

  • Kreicbergs A, Tribukat B (1984) Flow DNA analysis of primary bone tumors. Relationship between cellular DNA content and histopathologic Classification. Cancer 53: 129–136

    Article  PubMed  CAS  Google Scholar 

  • Lichtenstein L (1977) Bone tumors, 4th edn. C. V. Mosby, St. Louis

    Google Scholar 

  • Matsuno T, Unni KK, McLeod RA, Dahlin DC (1976) Telangiectatic osteogenic sarcoma. Cancer 38: 2538–2547

    Article  PubMed  CAS  Google Scholar 

  • Miettinen M, Letho CP, Virtanen I (1983) Differential diagnosis of chordoma, chondroid, and ependymal tumors as aided by anti-intermediate Filament antibody. Am J Pathol 112: 160–169

    PubMed  CAS  Google Scholar 

  • Roessner A (1984) Zur Zyto- und Histogenese der malignen und semimalignen Knochentumoren. Veröffentlichungen aus der Pathologie, H. 122. Gustav Fischer, Stuttgart

    Google Scholar 

  • Roessner A, Hobik HP, Grundmann E (1979) Malignant fibrous histiocytoma of bone and osteosarcoma. A comparative light and electron microscopy study. Path. Res. Pract. 164: 385–401

    Article  PubMed  CAS  Google Scholar 

  • Roessner A, Immenkamp M, Weidner A, Hobik HP, Grundmann E (1981) Benign fibrous histiocytoma of bone. Light and electron microscopic Observation. J Cancer Res Clin Oncol 101: 191–202

    Article  PubMed  CAS  Google Scholar 

  • Roessner A, Mellin W, Hiddemann W, Voss B, Vollmer E, Grundmann E (1984a) New cytomorphologic methods in the diagnosis of bone tumors: possibilities and limitations. Semin Diagn Pathol 13: 199–214

    Google Scholar 

  • Roessner A, v. Bassewitz DB, Schlake W, Thorwesten G, Grundmann E (1984b) Biological characterization of human bone tumors. III. Giant cell tumor of bone. Pathol Res Pract 178: 431–440

    Article  PubMed  CAS  Google Scholar 

  • Roessner A, Vollmer E, Sorg C, Grundmann E (1986) Die Rolle der Makrophagen und osteoklastenähnlichen Riesenzellen in Knochentumoren. In: Dietsch P, Keck E, Kruse HP, Kuhlencordt F (eds) Aktuelle Ergebnisse der Osteologie. W. de Gruyter, Berlin, pp 227–232

    Google Scholar 

  • Roessner A, Vassallo J, Vollmer E, Zwadlo G, Sorg C, Grundmann E (1987) Biological characterization of human bone tumors. X. The proliferation behavior of macrophages as compared to fibroblastic cells in malignant flbrous hastioeytoma and giant cell tumor of bone. J Cancer Res Clin Oncol 113: 559–562

    Article  PubMed  CAS  Google Scholar 

  • Rosen G, Caparros B, Huvos AG, Kosloff C, Nierenberg A, Cacavio A, Marcove RC, Labe JM, Metha B, Urban C (1982) Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer 49: 1221–1230

    Article  PubMed  CAS  Google Scholar 

  • Schajowicz F (1981) Tumors änd tumorlike lesions of the bones and joints. Springer, New York

    Google Scholar 

  • Schajowicz F, Ackerman LV, Sissons HA, Sobin LH, Torloni H (1972) Histological typing of bone tumours. International Classification of Tumours, vol 6. WHO, Geneva

    Google Scholar 

  • Spanier SS (1977) Malignant fibrous histiocytoma of bone. Orthop Clin North Am 8: 947–961

    Google Scholar 

  • Spjut HJ, Dorfman HD, Fechner RE, Ackerman LV (1971) Tumors of Bone and Cartilage. AF Atlas of Tumor Pathology II/5 AF Inst of Pathology, Washington/DC

    Google Scholar 

  • Unni KK, Dahlin DC (1984) Grading of bone tumors. Semin Diagn Pathol 13: 165–172

    Google Scholar 

  • Unni KK, Dahlin DC, McLeod RA, Pritchard DJ (1977) Intraosseous well-differentiated osteosarcoma. Cancer 40: 1337–1347

    Article  PubMed  CAS  Google Scholar 

  • Vollmer E, Bouropoulou V, Roessner A, Erwig H, Grundmann E (1985) Immunohistologische und elektronenmikroskopische Untersuchungen an Chordomen. Verh Dtsch Ges Pathol 69: 633

    Google Scholar 

  • Vollmer E, Roessner A, Lipecki KH, Zwadlo G, Hagemeier HH, Grundmann E (1987) Biologie characterization of human bone tumors. VI. The aneurysmal bone cyst: an enzyme histochemical, electron microscopical, and immunohistological study. Virchows Archiv 53: 58–65

    PubMed  CAS  Google Scholar 

  • Weibel ER, Elias H (1967) Quantitative methods in morphology. Springer, Berlin Heidelberg New York

    Google Scholar 

Download references

Authors
  1. E. Vollmer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Roessner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Wuisman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Härle
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. Grundmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Gerhard-Domagk-Institut für Pathologie der Universität, Domagkstraße 17, D-4400, Münster, Germany

    A. Roessner (Prof. Dr.) (Prof. Dr.)

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Vollmer, E., Roessner, A., Wuisman, P., Härle, A., Grundmann, E. (1989). The Proliferation Behavior of Bone Tumors Investigated with the Monoclonal Antibody Ki-67. In: Roessner, A. (eds) Biological Characterization of Bone Tumors. Current Topics in Pathology, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74462-4_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-74462-4_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74464-8

  • Online ISBN: 978-3-642-74462-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation