Expression of Epidermal Growth Factor Receptors on Renal Cell Carcinomas
The epidermal growth factor (EGF), a low molecular weight polypeptide, originally isolated from mouse submandibular glands and from human urine stimulates the proliferation of a variety of cells in cultures of both epithelial and mesenchymal origin (Cohen and Carpenter 1975; Gregory 1975). The EGF binds as well as the transforming growth factor-α (TGF-α) to the EGF-receptor located on the cell membranes of normal and transformed cells. This EGF-receptor is a 170000-dalton protein with an extracellular and an intracellular domain. The intracellular region of the EGF-receptor possesses tyrosine kinase activity, and there is autophosphorylation of tyrosine residues located near the carboxy terminus (Carpenter 1983; Downward et al. 1984b).
KeywordsRenal Cell Carcinoma Human Renal Cell Carcinoma Primary Renal Cell Carcinoma Mouse Submandibular Gland Partial Rank Correlation
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