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Expression of Epidermal Growth Factor Receptors on Renal Cell Carcinomas

  • W. Heckl
  • K. Becker
  • U. Wacker
  • B. Halliger
Conference paper

Abstract

The epidermal growth factor (EGF), a low molecular weight polypeptide, originally isolated from mouse submandibular glands and from human urine stimulates the proliferation of a variety of cells in cultures of both epithelial and mesenchymal origin (Cohen and Carpenter 1975; Gregory 1975). The EGF binds as well as the transforming growth factor-α (TGF-α) to the EGF-receptor located on the cell membranes of normal and transformed cells. This EGF-receptor is a 170000-dalton protein with an extracellular and an intracellular domain. The intracellular region of the EGF-receptor possesses tyrosine kinase activity, and there is autophosphorylation of tyrosine residues located near the carboxy terminus (Carpenter 1983; Downward et al. 1984b).

Keywords

Renal Cell Carcinoma Human Renal Cell Carcinoma Primary Renal Cell Carcinoma Mouse Submandibular Gland Partial Rank Correlation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • W. Heckl
  • K. Becker
  • U. Wacker
  • B. Halliger
    • 1
  1. 1.Department of UrologyUniversity of Würzburg Medical SchoolWürzburgGermany

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