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Investigative Urology 3 pp 197–208Cite as

Improvement of In Situ Renal Protection Against Complete Ischemia Through the Replacement of Chloride by Aspartate in the HTK Solution of Bretschneider

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Abstract

The cardioplegia solution, HTK (histidine-tryptophan-ketoglutarate) (Bretschneider et al. 1975, 1984; Bretschneider 1980), was primarily developed to improve myocardial protection, as compared with periods of ischemia, during artificial cardiac arrest in open heart surgery. It has since become a routine clinical procedure (Preusse et al. 1987). According to our results, this solution also significantly improves ischemic tolerance of kidneys (Kallerhoff et al. 1985a, b, 1986, 1987c). The superiority over simple ischemia or over the Euro Collins solution holds for “cold” as well as for “warm” ischemia (Kallerhoff et al. 1988a). Renal ischemic tolerance was increased from 15–20 min to 2 h at normothermia (Kallerhoff et al. 1986). There have now been several clinical applications of this method (Blech et al. 1988; Kallerhoff et al. 1988b).

Supported by the DFG, SFB 330-Organprotektion Dedicated, gratefully, to Prof. Dr. W. Knipper

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Author information

Authors and Affiliations

  1. Dept. of Urology, University of Göttingen, Robert-Koch-Str. 40, 3400, Göttingen, Germany

    M. Kallerhoff, M. Blech & R. H. Ringert

  2. Dept. of Physiology, University of Göttingen, Humboldtallee 23, 3400, Göttingen, Germany

    G. Kehrer, M. Langheinrich & H. J. Bretschneider

  3. Dept. of Pathology, University of Hamburg, Martini-Str. 52, 2000, Hamburg 20, Germany

    U. Helmchen

Authors
  1. M. Kallerhoff
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  2. M. Blech
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  3. G. Kehrer
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  4. M. Langheinrich
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  5. U. Helmchen
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  6. H. J. Bretschneider
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  7. R. H. Ringert
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Editor information

Editors and Affiliations

  1. Abteilung Urologie, Knappschaftskrankenhaus Bardenberg, Dr.-Hans-Böckler-Platz 1, D-5102, Würselen 1, Germany

    Herbert Rübben

  2. Urologische Klinik und Poliklinik Klinikum Großhadern, Ludwig-Maximilian-Universität München, Marchioninistr. 15, D-8000, München 80, Germany

    Dieter Jocham

  3. Urologische Fachpraxis, Friedrich-Ebert-Str. 176, D-4100, Duisburg 18, Germany

    Günther H. Jacobi

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© 1989 Springer-Verlag Berlin Heidelberg

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Kallerhoff, M. et al. (1989). Improvement of In Situ Renal Protection Against Complete Ischemia Through the Replacement of Chloride by Aspartate in the HTK Solution of Bretschneider. In: Rübben, H., Jocham, D., Jacobi, G.H. (eds) Investigative Urology 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74438-9_31

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  • DOI: https://doi.org/10.1007/978-3-642-74438-9_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74440-2

  • Online ISBN: 978-3-642-74438-9

  • eBook Packages: Springer Book Archive

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