Tumor Marker Characterization in the Serially Transplantable PC-EW Human Prostatic Carcinoma Line in Nude Mice
Prostatic acid phosphatase (PAP) and prostate specific antigen (PSA) are organ- specific substances. Although neither PAP nor PSA are tumor specific, their serum values in patients with prostate cancer frequently appear markedly elevated as compared with the values of healthy subjects or patients affected by malignancies of non- prostatic origin (Foti et al. 1977; Wang et al. 1979; Kuriyama et al. 1982). Since successful therapy causes a decrease in the serum levels of both substances, they can be regarded as useful tumor markers. Clinical findings during the past few years show that serum PSA can frequently be raised when the serum PAP is normal (Chu and Murphy 1986; Siddal et al. 1986; Ahmann and Schifman 1987). Preliminary studies in patients with prostate cancer have shown a correlation between the frequency of pathological PSA levels and disease stage, grade, and activity (Csapo et al. 1987). However, little data are available for comparing the indicator value of PSA with PAP.
KeywordsEstrogen Adenocarcinoma Progesterone Androgen Estradiol
Unable to display preview. Download preview PDF.
- Csapo Z, Sigel A, Brand K (1987) Significance of prostatic acid phosphatase (PAP) and prostate specific antigen ( PSA) in the diagnosis and follow-up of prostate cancer. Urologe B 27: 238–245Google Scholar
- Höhn W, Wagner M, Riemann JF, Hermanek P, Williams E, Walther R, Schrüffer R (1984) Prostatic adenocarcinoma PC-EW. A new human tumor line transplantable in nude mice. Prostate 5: 445–452Google Scholar
- Siddal JK, Cooper EH, Newling DWW, Robinson MRG, Whelan P (1986) An evaluation of the immunochemical measurement of prostatic acid phosphatase and prostatic specific antigen in carcinoma of the prostate. Eur Urol 12: 123–130Google Scholar