Biological Markers in the Evaluation of Prognosis in Patients with Renal Cell Carcinoma

  • B. J. Schmitz-Dräger
  • D. Rohde
  • H. Frenzel
  • R. Ackermann
Conference paper


Successful treatment of malignant disease is based on extensive knowledge of the biology of a given tumor and, as a consequence, the prognosis of the disease. At the moment, only a few parameters are known which correlate with the prognosis of renal cell carcinoma (RCC). Several investigators could demonstrate a close correlation between tumor stage and patient survival (Böttiger 1970; Golimbu et al. 1986; Giuliani et al. 1983; Klöppel et al. 1986; Robson et al. 1969). The impact of the tumor grade on the prognosis of the disease is a matter of discussion. While some authors report a good correlation between tumor grade and the course of the disease, this could not be confirmed by others (Donhuijsen 1986; Fuhrman et al. 1982; Klöppel et al. 1986; Kofler et al. 1975; Syrjänen and Hjelt 1978). Recently, the value of biological markers, e.g., DNA content, the expression of differentiation or proliferation antigens and of antigens belonging to the cytoskeleton, has been investigated (Bohle et al. 1986; Fleming and Symes 1987; Fleming and Brown 1987; Ljungberg et al. 1986; Loy et al. 1986).


Renal Cell Carcinoma Tumor Grade Renal Cell Carcinoma Tumor Proximal Tubular Epithelium Proliferation Antigen 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • B. J. Schmitz-Dräger
    • 1
  • D. Rohde
    • 1
  • H. Frenzel
    • 2
  • R. Ackermann
    • 1
  1. 1.Department of UrologyUniversity of Düsseldorf, Medical SchoolDüsseldorfGermany
  2. 2.Institute of PathologyUniversity of DüsseldorfGermany

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