Clinical Effects of Selective Serotonin Reuptake Inhibitors
Meta-analysis of controlled clinical trials has recently been established as a discipline that critically reviews and statistically combines the results of new treatment modalities. The objectives of a meta-analysis are to increase statistical power in detecting differences between treatments and to resolve un-certainties in the case of conflicting results. A meta-analytic literature review takes the trial itself as unit of analysis and consequently gives equal weight to each trial. A study of on-file data calculates the central tendency of the pooled data set, in which the individual patient in the trial is the unit for calculation of means, standard deviations, etc.
KeywordsPlacebo Depression Lithium Serotonin Diazepam
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