Evaluation of Clinical and Biological Parameters in Healthy Volunteers: More than Pharmacokinetics and Side Effects?

  • A. J. Puech
  • P. Danjou
  • D. Warot
  • G. Bensimon
  • L. Lacomblez
Conference paper
Part of the Psychopharmacology Series book series (PSYCHOPHARM, volume 7)


For ethical, scientific and economic reasons, new drugs must be studied carefully before their first clinical evaluation in patients. The amount of data from animals and humans available before administration to patients has increased in recent years. Presently, most data available in healthy volunteers concern pharmacokinetics and side effects.


Sleep Deprivation Psychoactive Drug Active Dose Inescapable Shock Critical Flicker Frequency 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • A. J. Puech
  • P. Danjou
  • D. Warot
  • G. Bensimon
  • L. Lacomblez
    • 1
  1. 1.Departement de pharmacologie cliniqueGroupe Hospitalier Pitié-SalpetrièreParis Cedex 13France

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