Receptor Subtypes and Endogenous Ligands: Rational Tools in the Search for Psychotropic Drugs
Relatively few new pharmacodynamic principles have been introduced in the late 1970s and early 1980s for the treatment of psychiatric disorders. This may reflect the type of experimental procedures used in the late 1960s and early 1970s, when animal models for psychiatric diseases were widely used for screening in the early discovery phases. These models, which were usually based on the performance of known efficacious psychotropic drugs, had a tendency to produce compounds which were similar to already known drugs. Today it seems that more rational approaches to the development of new CNS-active compounds have evolved in parallel with the explosive development in receptor research, and the results of these approaches are beginning to emerge.
KeywordsDopamine Schizophrenia Cocaine Explosive Histamine
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