Effects of Selenium Deficiency on Mouse Articular Cartilage

Abstract

An edemic form of osteoarthritis, Kashin-Beck disease, has been reported to be associated with low levels of selenium (Se) in the soil, foods, and hair of individuals from areas where this condition is common (Li et al. 1987; Mo 1987). However, other agents have been implicated in its etiology (Sokoloff 1985). Ren (1982) and Mo (1987) fed rats diets low in Se and found no necrotic areas in the articular cartilage. Nevertheless, as we had observed deformities in Se-deficient mice in our previous work, we determined to examine this tissue. Light and transmission electron microscopy showed it was affected by Se deficiency.

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