Effects of Selenium Deficiency on Mouse Articular Cartilage

  • K. Ploetz
  • E. Wallace
Conference paper

Abstract

An edemic form of osteoarthritis, Kashin-Beck disease, has been reported to be associated with low levels of selenium (Se) in the soil, foods, and hair of individuals from areas where this condition is common (Li et al. 1987; Mo 1987). However, other agents have been implicated in its etiology (Sokoloff 1985). Ren (1982) and Mo (1987) fed rats diets low in Se and found no necrotic areas in the articular cartilage. Nevertheless, as we had observed deformities in Se-deficient mice in our previous work, we determined to examine this tissue. Light and transmission electron microscopy showed it was affected by Se deficiency.

Keywords

Formalin Arthritis Citrate Selenium Osteoarthritis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Li JY, Ren S-X, Cheng D-Z, Wan H-J, Liang S-T, Zhang F-J, Gao F-M (1987) Distribution of selenium in the microenvironment related to Kashin-Beck disease. In: Coombs GF, Spallholz JE, Levander OA, Oldfield JE (eds) Selenium in biology and medicine. AVI Van Nostrand Reinhold Company, New York, pp 911–923Google Scholar
  2. Mo DX (1987) Pathology of Kaschin-Beck disease. In: Coombs GF, Spallholz JE, Levander OA, Oldfield JE (eds) Selenium in biology and medicine. AVI Van Nostrand Reinhold Company, New York, pp 924–933Google Scholar
  3. Ren HZ (1982) A histological study concerning the effects of trace element selenium on the development of metaphyseal cartilage of rat. Chin J Pathol 11: 220–221, 44Google Scholar
  4. Sokoloff L (1985) Endemic forms of osteoarthritis. Clin Rheum Dis 11: 187–202PubMedGoogle Scholar
  5. Wallace E, Calvin HI, Cooper GW (1983) Progressive defects observed in mouse sperm during the course of three generations of selenium deficiency. Gamete Res 4: 377–387CrossRefGoogle Scholar
  6. Wallace E, Calvin HI, Ploetz K, Cooper GW (1987) Functional and developmental studies on the role of selenium in spermatogenesis. In: Coombs GF, Spallholz JE, Levander OA, Oldfield JE (eds) Selenium in biology and medicine. AVI Van Nostrand Reinhold Company, New York, pp 181–196Google Scholar
  7. Wei X, Wright GC, Sokoloff L (1986) The effect of sodium selenite on chondrocytes in monolayer culture. Arthritis and Rheum 29: 660–664CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • K. Ploetz
    • 1
  • E. Wallace
    • 1
  1. 1.Biology DepartmentWilliam Paterson College of New JerseyWayneUSA

Personalised recommendations