Selenium Intake Induces Growth Retardation Through Reversible Growth Hormone and Irreversible Somatomedin C Suppression
Growth retardation is an outstanding symptom in animals exposed to toxic doses of selenium and is one of the main symptoms in stocks with alkali disease. Even Moxon (1937) demonstrated a convincing correlation between the dose of selenium consumed by experimental animals and the level of growth retardation. These results have later been confirmed by many others and the National Research Council concluded in 1976 that growth retardation may be the best indicator of selenium toxicity. The mechanism behind this symptom has, however, not been clearly established although reduced food intake seems to be a part of this mechanism.
KeywordsGrowth Hormone Sodium Selenite Organic Selenium Selenite Treatment Selenium Toxicity
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