The Regulation of Glutathione Peroxidase Gene Expression; Implication for Species Difference and the Effect of Dietary Selenium Manipulation
Glutathione peroxidase (GSH-Px) is considered to be a housekeeping enzyme, functioning as an important antioxidant enzyme which protects cells from oxidative damage. GSH-Px protein contains a selenocysteine (Se-Cys) moiety in its active site, but the mechanism of Se-Cys incorporation into the polypeptide chain of the enzyme protein has long been unresolved. Chambers et al. (1986) discovered that a UGA termiation codon in the open reading frame of murine GSH-Px mRNA was utilized as a codon for Se-Cys. This finding has encouraged the elucidation of the regulatory mechanism of GSH-Px gene expression. Evidence so far obtained has implied a quite complicated regulatory system for the synthesis of this selenoprotein.
KeywordsHydrogen Peroxide Depression Codon Glutathione Superoxide
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