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The Peroxisomal β-Oxidation Systems: Characteristics and (Dys) Functions in Man

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Book cover Molecular Basis of Membrane-Associated Diseases

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Abstract

Peroxisomes are now known to be present in virtually every mammalian cell except the mature erythrocyte. They were first described by Rhodin in 1954 as “spheric or oval bodies” present in the cytoplasm of mouse proximal kidney tubules [1]. Evidence that these “microbodies” were, indeed, different from the other subcellular organelles known at that time, came from cell fractionation experiments by de Duve and co-workers (see [2] for review). The identification of catalase and several Hb2O2-producing oxidases (D-aminoacid oxidase, urate oxidase, glycollate oxidase) within this organelle prompted de Duve and co-workers to introduce the name “peroxisome”.

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Authors and Affiliations

  1. Department of Pediatrics, University Hospital Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

    R. J. A. Wanders, C. W. T. Van Roermund, M. J. A. Van Wijland & R. B. H. Schutgens

  2. Department of Biochemistry, State University Utrecht, Padualaan 9, 3584 CH, Utrecht, The Netherlands

    H. Van Den Bosch

  3. Department of Biochemistry, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands

    J. M. Tager

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  1. R. J. A. Wanders
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  3. M. J. A. Van Wijland
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  4. R. B. H. Schutgens
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Editors and Affiliations

  1. Institut für Biochemie und Molekularbiologie, Universität Bern, Bühlstraße 28, CH-3012, Bern, Switzerland

    Angelo Azzi

  2. Institute of Physiology, Czechoslovak Academy of Sciences, Videnska 1083, CS-142 20, Praha 4, Czech Republic

    Zdenek Drahota

  3. Institute of Medical Biochemistry and Chemistry, University of Bari, Piazza G. Cesare, I-70124, Bari, Italy

    Sergio Papa

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Wanders, R.J.A., Van Roermund, C.W.T., Van Wijland, M.J.A., Schutgens, R.B.H., Van Den Bosch, H., Tager, J.M. (1989). The Peroxisomal β-Oxidation Systems: Characteristics and (Dys) Functions in Man. In: Azzi, A., Drahota, Z., Papa, S. (eds) Molecular Basis of Membrane-Associated Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74415-0_34

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