The Complex of β-Galactosidase, Neuraminidase and “Protective Protein” in Lysosomes: Molecular Characterization of the “Protective Protein”

  • A. D’Azzo
  • N. Gillemans
  • N. Galjart
Conference paper


Human lysosomal β-D-galactosidase and N-acetyl-α-neuraminidase (sialidase) are hydrolytic enzymes responsible for the degradation of a variety of natural and synthetic substrates (for review see [1,2]). They are associated in their functional state with a third glycoprotein, referred to as “protective protein” [3,4]. These three glycoproteins copurify as a complex, the molecular basis of which is so far poorly understood.


Protective Protein Neuraminidase Activity Putative Protease Bovine Testis High Molecular Weight Aggregate 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • A. D’Azzo
    • 1
  • N. Gillemans
    • 1
  • N. Galjart
    • 1
  1. 1.Department of Cell Biology and GeneticsErasmus UniversityRotterdamThe Netherlands

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