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A Contribution to the Assessment of Pathophysiology in Long-Term Total Artificial Heart Recipients

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Abstract

The implantation of total artificial hearts (TAHs) has become an ever more important tool of cardiosurgery in saving the lives of potential recipients of biological transplants when a donor organ is not immediately available. Clinical experience with this bridging procedure is now accelerating. In addition, some clinical experience with permanent TAH implantation has been gathered [1, 2]. This knowledge is advancing methodological procedures concerning the implantation technique, the construction of TAH devices and control and driving units, and the postoperative management of patients. Also, for the first time we can learn of the subjective feelings of TAH recipients. Thus, future clinical development is now a well established branch of TAH research and research into heart transplantation in general. On the other hand, some basic problems concerning permanent TAH implantation in humans have to be solved; these problems derive from the technical equipment and/or from the physiology of the organism with the TAH implanted.

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References

  1. Olsen Don (1987) ISAO - International registry bridge to transplant experience with the Jarvik-7 and the Jarvik-7-70 total artificial heart. Artif Organs 11:63–68

    Article  Google Scholar 

  2. Symbion (1987) Clinical update - a current report on use of the Jarvik-7 (100 cc) and Jarvik- 7 (70 cc) as a bridge to transplant (April 3). Salt Lake City, Utah, USA

    Google Scholar 

  3. Magovern JA, Rosenberg G, Pierce WA (1986) Development and current status of a total artificial heart. Artif Organs 10:357–363

    Article  PubMed  CAS  Google Scholar 

  4. Vašků J (1982) Artificial heart. Pathophysiology of the total artificial heart and of cardiac assist devices. University J. E. Purkyně Press

    Google Scholar 

  5. Vašků J (1984) BRNO experiments in total artificial heart. Brno, University J.E. Purkyně Press

    Google Scholar 

  6. Dostál M, Vašků J, Černý J, Šotolová O, Guba P, Vašků J, Urbánek P, Pavlíček V, Vašků A, Nečas J, Sláděk T, Trbušek V, Bednařrík B (1986) Hematological and biochemical studies in calves living over 100 days with the polymethylmethacrylate total artificial heart TNS- BRNO II. Int J Artif Organs 9:39–48

    PubMed  Google Scholar 

  7. Weidemann H (1985) Künstlicher Totalherzersatz. Korrelation klinischer, hämodynamischer und morphologischer Befunde in vier Entwicklungsphasen (1972–1984). Habilitation Thesis, Berlin, FU, p 207

    Google Scholar 

  8. Atsumi K (1986) TAH pathophysiology in the goat. In: Bücherl ES (ed) Proceedings second world symposium artificial heart, vol 1. Vieweg, Berlin 1984, pp 378–383

    Google Scholar 

  9. Olsen DB, Westenfelder C, Burns GL, Kablitz C, Baranowski R (1986) Neurohormonal responses in total artificial heart recipients. In: Nosé Y, Kjellstrand C, Iwanovich P (eds) Progress in artificial organs 1985. Isao, Cleveland, pp 112–118

    Google Scholar 

  10. Atsumi K (1987) Fundamental studies on implantable total artificial heart (TAH) - guest lecture. Internat meeting on heart transplantation, total artificial heart and assist devices. Brussels 23–25 March 1987 (abstr)

    Google Scholar 

  11. Vašků J (1984) Total artificial heart research in Czechoslovakia. In: Unger F (ed) Assisted circulation. Springer, Berlin Heidelberg New York Tokyo, pp 254–269

    Google Scholar 

  12. Vašků J (1986) Calcification of the TAH driving diaphragms. In: Bücherl ES (ed) Proceeding of the second world symposium artificial heart, vol 1. Vieweg, Berlin 1984, pp 45–58

    Google Scholar 

  13. Vašků J, Černý J, Dostál M, Urbánek P, Vašků J, Guba P, Sládek T, Trbušek V, Vašků A, Hartmannová B, Urbánek E, Doležel S, Pavlíček V, Svoboda P (1985) Calcifying lesions of the driving diaphragms, observed in the total artificial hearts (TAH) TNS-BRNO. II. Life support systems. Proceedings XI annual meeting ESAO-Alpbach, vol 2(1). Innsbruck, September 1984, pp 242–244

    Google Scholar 

  14. Vašků J (1986) Total artificial heart research in Czechoslovakia: pathophysiological evaluation of long-term experiments performed from 1979–1985. In: Akutsu T (ed) Artificial heart. 1. Proceedings of the 1st international symposium on current problems for further development of artificial heart and assist devices, Tokyo, Aug 2–3, 1985. Springer, Berlin Heidelberg New York Tokyo, pp 161–179

    Google Scholar 

  15. Vašků J, Černý J, Vašků J, Urbánek E, Dostál M, Urbánek P, Guba P, Pavlíček V, Sládek T, Smutný M, Úlehla T, Hartmannová B, Trbušek V, Janečkovà H, Šotolová O, Sotáková E, Wendsche P, Doležel S, Filkuka J, Gregor Z, Bednařík B, Svoboda P (1983) A comparative study of a group of eight calves surviving longer than 1 month with the total artificial heart. Artif Organs 7:470–478

    Article  PubMed  Google Scholar 

  16. Vašků J, Černý J, Urbánek P, Vašků J, Dostál M, Guba P, Gregor Z, Svoboda P, Trbušek T, Šotolová O, Wendsche P, Filkuka J, Pavlíček V, Smutný M, Bednařík B, Vašků A, Doležel S, Sládek T, Hartmannová B, Urbánek E, Fiala V (1984) Long term evaluation of total artificial hearts in calves. Heart Transplant 4:81–88

    Google Scholar 

  17. Klimeš F, Kořenář F, Toman J, Pech P, Gardavský J (1987) The study of the oscillating and pulsating velocity connection of the Newton fluid in the nonelastic tube with symmetrical obstacle and in the blood chamber of the total artificial heart and further the study of the Newton fluid in the elastic tube (numeric, visualization and laser-Doppler anemometry method). Research report - Institute of Hydrodynamics, Czechoslovak Academy of Sciences, Prague 1987, p 41 (in Czech)

    Google Scholar 

  18. Vašků J, Urbánek P, Vašků J, Černý J, Smutný M, Urbánek E, Suchánek J, Gregor Z, Dostál M, Guba P, Sládek T, Wendsche P, Pavlíček V, Trbušek V, Šotolová O, Úlehla T, Fiala V (1986) Control and driving of pneumatic total artificial heart TNS-BRNO II and III in long term experiments. Artif Organs 10:145–152

    Article  PubMed  Google Scholar 

  19. Vašků J (1986) BRNO portable driving system. In: Bücherl ES (ed) Proceedings second world symposium artificial heart, vol 1. Vieweg, Berlin, pp 145–148

    Google Scholar 

  20. Urbánek P, Vašků J, Úlehla T, Vašků J, Dostál M, Guba P (1986) In vivo testing of electropneumatic portable driving system for the total artificial heart. Life support systems, vol 4, suppl 2. XIII Annual meeting Avignon, pp 44–16

    Google Scholar 

  21. Harasaki H, McMahon J, Richards JR, Goldcamp J, Király R, Nosé Y (1985) Calcification in cardiovascular implants: degraded cell related phenomena. Trans Am Soc Artif Intern Organs 31:489–494

    PubMed  CAS  Google Scholar 

  22. Vašků J Calcification of the driving diaphragm in a total artificial heart. Czech Med (in press)

    Google Scholar 

  23. Tomazic BB, Etz ES, Brown WE (1987) Nature and properties of cardiovascular deposits. Scanning Microscopy 1:95–105

    PubMed  CAS  Google Scholar 

  24. Boskey AL, Posner AS (1977) The role of synthetic and bone extracted Ca-phospholipid- phosphate complexes in hydroxyapatite formation. Calcif Tissue Res 23:251–258

    Article  PubMed  CAS  Google Scholar 

  25. Eanes ED, Termine JD (1983) Calcium in mineralized tissues. In: Spiro TG (ed) Calcium in biology. Wiley Interscience, New York, pp 203–233

    Google Scholar 

  26. Selye H (1962) Calciphylaxis. The University of Chicago Press

    Google Scholar 

  27. Vašků J (1967) Calciphylaxis, a new biological phenomenon and its importance. Státní zdra- votnické nakladatelstvi (in Czech)

    Google Scholar 

  28. Atsumi K, Imachi K (1984) Guest lecture in the research centre for artificial heart. BRNO, July 1984

    Google Scholar 

  29. Tomazic B (1986) Mechanisms of the mineralization processes. Guest lecture - research centre for artificial heart. BRNO, August 1986

    Google Scholar 

  30. Hughes SD, Coleman OL, Dew PA, Burns GL, Olsen DB, Kolff W (1984) Effects of Coumadin on thrombus and mineralization in total artificial hearts. Trans Am Soc Artif Intern Organs 30:75–79

    PubMed  CAS  Google Scholar 

  31. Vašků J, Černý J, Urbánek E, Trbušek V, Vašků J, Urbánek P, Dostál M, Guba P, Smutný M, Úlehla T, Pavlíček V, Suchánek J, Sládek T, Bednařík B, Svoboda P (1984) Evaluation of the changes in kinetic components of a total artificial heart after several months of pumping. Progress in artificial organs (Isao, Kyoto 1983), vol 1. Isao no 204, Cleveland, pp 204–210

    Google Scholar 

  32. Vašků J, Černý J, Urbánek P, Dostál M, Doležel S, Guba P, Vašků J, Smutný M, Sládek T, Filkuka J, Pavlíček V, Trbušek V, Bednařík B (1986) In: Nosé Y, Kjellstrand C, Ivanovich P (eds) Central venous pressure in calves surviving several months with a total artificial heart - progress in artificial organs - 1985. Isao, Cleveland, pp 386–392

    Google Scholar 

  33. Vašků J, Vašků J, Černý J, Dostál M, Guba P, Doležel S, Urbánek P, Bednařík B (1986) Changes of vasomotoric regulations in TAH bearers, life support systems, vol 4, suppl 2. Proceedings XIII annual meeting ESAO, Avignon, pp 32–34

    Google Scholar 

  34. Vašků J, Černý J, Dostál M, Guba P, Vašků J, Urbánek P, Vašků A, Doležel S (1987) Neurohumoral aspects of total artificial heart. Internat meeting on heart transplant. Total artificial heart and the assist devices, Brussels, 23–25 March 1987, p 43 (abstr)

    Google Scholar 

  35. Öberg B (1978) Aspects of reflex control of the capacitance vessels. In: Chermukh AM, Tkachenko BI, Kovach AGB, Biró S (eds) Regulation of the capacitance vessels. Akadémiai Kiadó, Budapest, pp 197–224

    Google Scholar 

  36. Shepherd JT (1978) Reflex control of the capacitance vessels. In: Chernukh AM, Tkachenko BI, Kovach AGB, Biró S (eds) Regulation of the capacitance vessels. Akadémiai Kiadó, Budapest, pp 145–196

    Google Scholar 

  37. Vašků J (1985) Pathophysiological aspects of the total artificial heart research - new trends in pathological physiology, opuscula pathophysiologica. Acta Fac Med Univ Brun 92:65–74

    Google Scholar 

  38. Vašků J, Černý J, Dostál M, Guba P, Vašků J, Urbánek P, Urbánek E, Pavlíček V, Gregor Z, Wendsche P, Sládek T (1985) Total artificial heart (TAH), pathophysiological aspects based on our own observations. Ergeb Exp Med 46:522–532

    Google Scholar 

  39. Arndt JO (1986) The low pressure system: the integrated function of veins. Eur J Anaes- thesiol 3:343–370

    CAS  Google Scholar 

  40. Vašků J, Štengold EŠ, Kolmanovskij VB, Naumov VE, Drozdov AD (in press) Patofiziolo- gičeskije mechanizmy venoznoj giperten zii u teljat s iskustvennym serdcom. Doklady Aka- demii Nauk SSSR (in russian)

    Google Scholar 

  41. Vašků J, Vašků J, Dostál M, Černý J, Guba P, Doležel S, Vašků A, Pavlíček V, Urbánek P (1987) Total artificial heart (TAH) - a modelling system for the study of pathophysiology of vascular regulations. 4th IMEKO conference “Advances in biomedical measurement,” Bratislava, May 17–20, 1987 (abstr K-6)

    Google Scholar 

  42. Vašků J (1987) Recent actual problems on the total artificial heart research in Czechoslovakia, 6th world ISAO and 14th ESAO congress, Munich, September 1987 (abstr)

    Google Scholar 

  43. Vašků J, Vašků J, Dostál M, Černý J, Guba P, Doležel S, Vašků A, Mašek J, Urbánek P, Krejěí V (1987) Electric activity of biological atria in total artificial heart (TAH). 4th IMEKO conference “Advances in biological measurement”, Bratislava, May 17–20, 1987 (abstr K-11)

    Google Scholar 

  44. Vašků J, Vašků J, Dostál M, Urbánek P, Guba P (1987) The relation of atrial P-wave frequency to the central venous pressure (CVP) increase and the administration of alpha-1- blocking agents and alpha-methyldopa in the total artificial heart (TAH) animals. 6th world ISAO and 14th ESAO congress, Munich, September 1987 (abstr)

    Google Scholar 

  45. Dostál M, Vašků J, Bílková B, Vašků J, Černý J, Guba P, Doležel S, Vašků A, Nečas J (1987) Changes of hormonal feedback mechanism of calves with the total artificial hearts - 4th IMEKO conferences “Advances in biological measurement,” Bratislava, May 17–20, 1987 (abstr K-10)

    Google Scholar 

  46. Dostál M, Vašků J, Bílková B, Vašků J, Černý J, Guba P, Doležel S, Vašků A, Nečas J (1987) Study of serum hormone levels (aldosterone, TSH, T3, T4) of calves with TAH - 6th world ISAO and 14th ESAO congress, Munich, September 1987 (abstr)

    Google Scholar 

  47. Fujimasa J, Imachi K, Nakajima M, Nabuchi K, Tsukagoshi S, Kouno A, Ono T, Takido N, Motomura K, Chinzai T, Abe Y, Atsumi K (1986) Pathophysiological study of a total artificial heart in a goat that survived 344 days. Progress in artificial organs - 1985. Isao, Cleveland, pp 345–353

    Google Scholar 

  48. Vašků J (1986) Central venous pressure in the TAH animals. In: Bücherl ES (ed) Proceedings second world symposium artificial heart, vol 1. Vieweg, Berlin, pp 383–394

    Google Scholar 

  49. Vašků J (1986) Physiology of metabolism and organ pathology in the calves with total artificial heart. In: Bücherl ES (ed) Proceedings second world symposium artificial heart, vol 1. Vieweg, Berlin, pp 425–135

    Google Scholar 

  50. Rosenberg G, Pierce WS, Landis DL, Snyder AJ, Richenbacher WE, Weiss W, Felder G (1985) Progress in the development of the Pennsylvania State University motor driven artificial heart. In: Unger F (ed) Assisted circulation 2. Springer, Berlin Heidelberg New York Tokyo, pp 270–285

    Google Scholar 

  51. Imachi K, Fujimasa M, Nakajima K, Nabuchi K, Tsukagoshi S, Motomura K, Miyamoto A, Takido N, Inou N, Kouno A, Ono T, Atsumi K (1984) Overall analysis of the cause of pathophysiological problems in total artificial heart animals by cardiac receptor hypothesis. Trans Am Soc Artif Intern Organs 30:591–593

    PubMed  CAS  Google Scholar 

  52. Akutsu T (1984) Current pathophysiological problems with the total artificial heart. Progress in artificial organs (Isao, Kyoto 1983), vol 1. Isao no 204, Cleveland, pp 162–164

    Google Scholar 

  53. Herbst WM, Lang RE (1986) Das Herz als endokrines Organ. Ber Pathol 103:571–581

    Google Scholar 

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Vašků, J. (1989). A Contribution to the Assessment of Pathophysiology in Long-Term Total Artificial Heart Recipients. In: Unger, F. (eds) Assisted Circulation 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74404-4_32

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  • DOI: https://doi.org/10.1007/978-3-642-74404-4_32

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