The Philadelphia Heart System — An Implantable Artificial Heart for a Transplant Center
The human implantation of the first total artificial heart (TAH) in 1969 by Cooley [1, 2] represented the efforts of many investigators and many years of research. During this and other implants to follow, the TAH clearly demonstrated its capacity to anatomically and functionally replace the diseased natural heart, relieving heart failure and restoring cardiac hemodynamics to normal. Further laboratory investigation was stimulated by these results and has since led to the development of more advanced device designs which incorporate advances in biocompatibility and mechanical reliability of the components and driving systems. Select clinical applications of the currently available devices have shown promising results, generating an increasing interest in more widespread clinical application of TAH devices [3–8].
KeywordsArtificial Heart Mechanical Circulatory Support Total Artificial Heart Blood Chamber Human Implantation
Unable to display preview. Download preview PDF.
- 2.Cooley DA, Liotta D, Hallman GL, Bloodwell RD, Leachman RD, Milan JD (1969) First human implantation of cardiac prosthesis for staged total replacement of the heart. Trans Am Soc Artif Intern Organs 15:252–263Google Scholar
- 4.Copeland JG, Emery RW, Levinson NM, Copeland J, McAleer MJ, Riley JE (1985) The role of mechanical support and transplantation in treatment of patients with end-stage cardiomyopathy. Circulation 70(2):7–12Google Scholar
- 9.Olsen DB, Riebman JB, DePaulis R, Durrant G, Nielsen SD (1987) Registry and tabulations of orthotopic total artificial hearts in man. Trans Am Soc Artif Intern Organs 33(3):182–191Google Scholar
- 10.DePaulis R, Riebman JB, Deleuze P, Olsen DB (1987) The total artificial heart: indications and preliminary results. J Cardiac Surg 1987 (in press)Google Scholar
- 13.Wurzel D, Kolff J, Missfeldt W, Wildevuur W, Hansen G, Brownstein L, Riebman J, DePaulis R, Kolff WJ (1987) Development of the Philadelphia heart system. ESAO 14: (in press)Google Scholar
- 14.Wurzel D, Wildevur W, Kolff J (1986) Instrumentation for deriving pneumatic TAH control signals from the drivelines pressure and flow. Trans Am Soc Artif Intern Organs 32:258–262Google Scholar
- 15.Wurzel D (1986) Cardiac prosthesis having integral blood pressure sensor. US Patent Application no 857896Google Scholar
- 16.Missfeldt W, Wurzel D, Kolff J (1986) An air powered artificial heart all pneumatic Driver. ABST internal symposium on artificial organs. Biomed Eng TransplantGoogle Scholar
- 17.Kolff J, Cavarocchi NC, Riebman JB, Jessup M (1988) The artificial heart; design capabilities and indications in the treatment of heart failure. Heart Failure (in press)Google Scholar