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Strategies to Integrate Laboratory Information into the Clinical Diagnosis of Hepatic and Acute Pancreatic Disease

  • Mario Werner
Conference paper
Part of the Progress in Clinical Biochemistry and Medicine book series (PCBM, volume 8)

Abstract

Liver diseases provide a general model for the formal analysis of the relative diagnostic weights of information obtained from different sources. Diagnosis of liver disease has three basic purposes: (1) differentiation of hemolytic, parenchymatous, and obstructive jaundice, (2) evaluation of disease course and therapeutic success, and (3) evaluation of the nature of the liver lesion. The capabilities of diagnostic findings to attain these goals can be measured according to three criteria: (1) selectivity in differential diagnosis and etiologic selectivity, (2) sensitivity, and (3) specificity with regard to morphologic changes. Applying these yardsticks to information obtained from signs and symptoms, biophysical findings and laboratory findings establishes: (1) clinical findings and liver function tests are the underpinnings of differential diagnosis, (2) liver function tests are ideal for the evaluation of the disease course, and (3) laparoscopy and liver biopsy are ideal for the evaluation of the nature of the liver lesion, but imaging procedures and liver function tests are frequently simpler means that contribute to it.

Keywords

Acute Pancreatitis Hepatic Metastasis Liver Lesion Obstructive Jaundice Pretest Probability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Mario Werner
    • 1
  1. 1.The George Washington University Medical CenterN.W., Washington, D.C.USA

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