Cobalamin-Folate Interrelations

  • I. Chanarin


While the biochemical roles of cobalamin and folate have been well defined for many years, the complex manner in which they interrelate in vivo and the mechanism by which cobalamin deficiency produces megaloblastosis in man remains unclear. Cobalamin is a coenzyme in two well-studied reactions in mammals: the synthesis of methionine by methylation of homocysteine and the conversion of methylmalonyl-CoA to succinyl-CoA by an intra-molecular rearrangement. Folate is a coenzyme in a variety of reactions by which single C units (C-l) are transferred from carbon donors such as serine, formate, methionine and histidine and are donated in the synthesis of purines, pyrimidines and methionine.


Serum Folate Methylenetetrahydrofolate Reductase Megaloblastic Anaemia Cobalamin Deficiency Methionine Synthesis 
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© Springer-Verlag Berlin Heidelberg 1989

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  • I. Chanarin

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