Abstract
Atopic dermatitis is an inflammatory skin disorder which frequently begins in early infancy. It is characterized by extreme pruritus, chronically relapsing course, and specific distribution. The rash is generally an erythematous, papulovesicular eruption, frequently with serous discharge and crusting, and progresses to a scaly, lichenified rash over time [1]. The distribution of the rash typically varies with age [2], involving the cheeks and extensor surfaces of the arms and legs in infancy, the flexor surfaces in the young child, and flexor surfaces, hands and feet in the teenage patient and young adult. Unlike most dermatoses, atopic dermatitis has no primary skin lesion but is identified by a constellation of symptoms. The classification system recently proposed by Hanifin and Rajka [3] has been generally accepted and provides suitable diagnostic criteria for the disorder.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Supported by grants AI24439 and AI00830 from the National Institute of Allergy and Infectious Diseases and by grants RR-30 and RR-00052 from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health. Data was managed and analyzed with CLINFO. The author is a recipient of the Allergic Diseases Academic Award, NIH.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Blaylock WK (1976) Atopic dermatitis: diagnosis and pathobiology. J Allergy Clin Immunol 57:62–79
Hill LW, Sulzberger MG (1935) Evaluation of atopic dermatitis. Arch Belg Dermatol Syphiligr 32:451–463
Hanifin JM, Rajka G (1980) Diagnostic features of atopic dermatitis. Acta Derm Venerol 92 (Suppl): 44–47
Hanifin JM (1981) Atopic dermatitis. In: Safari B, Good RA (eds) Comprehensive immunology. Plenum, New York, p 301
Wise F, Sulzberger MB (1983) Yearbook of dermatology and syphilology. Yearbook Medical, Chicago, p 59
Johnson ML (1977) Prevalence of dermatologic disease among persons 1–74 years of age: United States. Advance data from vital and health statistics of the National Center for Health Statistics, no 4
Kjellman N-IM (1977) Atopic disease in seven year old children. Acta Paediatr Scand 66:465–471
Hanifin JM (1986) Pharmacophysiology of atopic dermatitis. Clin Rev Allergy 4:43–65
Leung DYM, Geha RS (1986) Immunoregulatory abnormalities in atopic dermatitis. Clin Rev Allergy 4:67–86
NIAID Task Force Report (1979) Dermatologic allergy. Asthma and the other allergic diseases. NIH Publication no 79-387, (1974) p 375
Johnson E, Irons J, Patterson R, Roberts M (1974) Serum IgE concentration in atopic dermatitis. J Allergy Clin Immunol 54:94–99
Rajka G (1975) The Aetiology of atopic dermatitis. In: Rook A (ed) Major problems in dermatology. Atopic dermatitis, vol 3. Saunders, London, pp 52–54
Hofman DR, Yamamoto FY, Sellar B, Haddad Z (1975) Diagnosis of IgE-me-diated reactions to food antigens by radioimmunoassay. Clin Immunol 55:256–267
Pasternack B (1965) The prediction of asthma in infantile eczema. J Pediatr 66:164–165
Stifler WC (1965) A twenty-one year follow-up of infantile eczema. J Pediatr 66:166–167
Mihm MC, Soter NA, Dvorak HF, Austen KF (1976) The structure of normal skin and the morphology of atopic eczema. J Invest Dermatol 67:305–312
Sampson HA (1985) Role of immediate food hypersensitivity in the pathogenesis of atopic dermatitis. J Allergy Clin Immunol 71:473–478
Sampson HA, Jolie PA (1984) Increased plasma histamine concentrations after food challenges in children with atopic dermatitis. N Engl J Med 311:372–376
Sampson HA, Broadbent K (1987) “Spontaneous” basophil histamine release and histamine releasing factor in patients with atopic dermatitis and food hypersensitivity. J Allergy Clin Immunol 79:241
Paganelli R, Levinsky RJ, Brostoff J, Wraith DG (1979) Immune complexes containing food proteins in normal and atopic subjects after oral challenge and effect of sodium cromoglycate on antigen absorption. Lancet 1:1270
Brostoff J, Carini C, Wraith DG, Johns P (1979) Production of IgE complexes by allergen challenge in atopic patients and the effect of sodium cromoglycate. Lancet 1:1268
Paganelli R, Atherton DJ, Levinsky R (1983) Differences between normal and milk allergic subjects in their immune responses after milk ingestion. Arch Dis Child 58:201
Chenowith DE, Hugli TE (1980) Biologically active peptides of complement: techniques and significance of C3a and C5a measurement. In: Nakamura RM, Tucker ES (eds) Immunoassays: clinical laboratory techniques for the 1980’s. Liss, New York, pp 443–461
Sampson HA, McCaskill CM (1985) Food hypersensitivity in atopic dermatitis: evaluation of 113 patients. J Pediatr 107:669
Dolovich J, Hargreave FE, Chalmers R, Shier KJ, Gauldre J, Bienenstock J (1973) Late cutaneous allergic responses in isolated IgE-dependent reactions. J Allergy Clin Immunol 52:38
Solley GO, Gleich GJ, Jordan RE, Schroeter AL (1976) The late phase of the immediate wheal and flare skin reaction: its dependence upon IgE antibodies. J Clin Invest 58:408
Brunner M, Walzer M (1928) Absorption of undigested proteins in human beings: the absorption of unaltered fish protein in adults. Arch Intern Med 42:173
Wilson SJ, Walzer M (1935) Absorption of undigested proteins in human beings. IV. Absorption of unaltered egg protein in infants. Am J Dis Child 50:49
Gleich GJ, Leiferman KM (1986) Eosinophils and hypersensitivity disease. In: Reed CE (ed) Proceedings of the XII International Congress of Allergology and Clinical Immunology. Mosby, St. Louis, pp 124–130
Leiferman KM, Peters MS, Gleich GJ (1986) The eosinophil and cutaneous edema. J Am Acad Dermatol 15:513
Leiferman KM, Ackerman SJ, Sampson HA, Haugen HS, Venenice PY, Gleich GJ (1985) Dermal deposition of eosinophil granule major basic protein in atopic dermatitis: comparison with onchocerciasis. N Engl Med 313:282–285
Gleich GJ, Frigas E, Loegering DA, Wassom DL, Steinmuller D (1979) Cytotoxic properties of eosinophil major basic protein. J Immunol 123:2925–2927
O’Donnel MC, Ackerman SJ, Gleich GJ, Thomas LL (1983) Activation of basophil and mast cell histamine release by eosinophil granule major basic protein. J Exp Med 157:1981–1991
Thueson DO, Speck LS, Lett-Brown MA, Grant JA (1979) Histamine-releasing activity. I. Production by mitogen-or antigen-stimulated human mononuclear cells. J Immunol 123:626
Thueson DO, Speck LS, Lett-Brown MA, Grant JA (1979) Histamine-releasing activity. II. Interaction with basopohils and physicochemical characterization. J Immunol 123:633
Sedgwick JD, Holt PG, Turner KJ (1981) Production of a histamine-releasing lymphokine by antigen-or mitogen-stimulated human peripheral T cells. Clin Exp Immunol 45:409
Kaplan AP, Haak-Frendscho M, Fauci A, Dinarello L, Haibert E (1985) A histamine-releasing factor from activated human mononuclear cells. J Immunol 135:2027
Schulman ES, Proud D, Liu MC, MacGlashan DW, Lichtenstein LM, Plaut M (1985) Human lung macrophages induce histamine release from basophils and mast cells. Am Rev Respir Dis 131:230
Orchard MA, Kagey-Sobotka A, Proud D, Lichtenstein LM (1986) Basophil histamine release induced by a substance from stimulated human platelets. J Immunol 136:2240
McDonald SM, Lichtenstein LM, Proud D, Plaut M, Naclerio RM, MacGlashan DW, Kagey-Sobotka A (1987) Studies of IgE-dependent histamine releasing factors: heterogeneity of IgE. J Immunol 139:506
Marone G, Giugliano R, Lembo G, Ayala F (1986) Human basophil releasability. II. Changes in basopohil releasability in patients with atopic dermatitis. J Invest Dermatol 87:19
Yodoi J, Ishizaka K (1979) Lymphocytes bearing Fc-receptors for IgE. 1. Presence of human and rat lymphocytes with FcE-receptors. J Immunol 122:2577
Spiegelberg HL (1984) Structure and function of Fc receptors for IgE on lymphocytes, monocytes and macrophages. Adv Immunol 35:61
Capron M, Spiegelberg HL, Prin L, Bennich H, Butterworth AE, Pierce RJ, Ouaissi M, Capron A (1984) Role of IgE receptors in effector function of human eosinophils. J Immunol 132:462
Capron A, Ameisen JC, Joseph M, Auriault C, Tonnel AB, Caen J (1985) New functions for platelets and their pathological implications. Int Arch Allergy Appl Immunol 77:107
Cines DB, van der Keyl H, Levinson AI (1986) In vitro binding of an IgE protein to human platelets. J Immunol 136:3433
Bruynzeel-Koomen C, van Wichen DF, Toonstra J, Berrens L, Bruynzeel PLB (1986) The presence of IgE molecules on epidermal Langerhans cells in patients with atopic dermatitis. Arch Dermatol Res 278:199
Sampson HA, Albergo R (1984) Comparison of results of skin tests, RAST, and double-blind placebo-controlled food challenges in children with atopic dermatitis. J Allergy Clin Immunol 74:26–33
Burks AW, Sampson HA (1988) A controlled trial of oral cromolyn in children with atopic dermatitis and documented food hypersensitivity. J Allergy Clin Immunol 81:417–423
Ohman S, Johansson SGO (1974) Immunoglobulins in atopic dermatitis. Acta Derm Venerol 54:193–202
Stone SP, Gleich GJ, Muller SA (1976) Atopic dermatitis and IgE relationship between changes in IgE levels and severity of disease. Arch Dermatol 112:1254–1255
Kajosaari M, Saarinen UM (1983) Prophylaxis of atopic disease by six months total solid food elimination. Acta Paediatr Scand 72:411
Saarinen UM, Kajosaari M (1980) Does dietary elimination in infancy prevent or only postpone a food allergy? Lancet 1:166
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Sampson, H.A. (1989). The Significance of Food Allergy in Atopic Dermatitis. In: Harms, H.K., Wahn, U. (eds) Food Allergy in Infancy and Childhood. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74357-3_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-74357-3_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-50636-2
Online ISBN: 978-3-642-74357-3
eBook Packages: Springer Book Archive