Advertisement

Immune Responses of the Young to Foods: Developmental Aspects of Food Allergy

  • S. Strobel
Conference paper

Abstract

The risk of developing a food-sensitive (allergic) disease is generally higher in children than it is in adults. This clinical observation highlights the importance of — as yet ill-defined — perinatal factors in the development of food-allergic diseases.

Keywords

Breast Milk Food Allergy Oral Tolerance Systemic Immune Response Mucosal Immune System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hayward AR (1981) Development of lymphocyte responses and interactions in the human fetus and newborn. Immunol Rev 57:39–60PubMedCrossRefGoogle Scholar
  2. 2.
    Hill HR (1987) Biochemical, structural, and functional abnormalities of polymorphonuclear leukocytes in the neonate. Pediatr Res 22:375–382PubMedCrossRefGoogle Scholar
  3. 3.
    Wilson CB (1986) Immunologic basis for increased susceptibility of the neonate to infection. J Pediatr 108:1–12PubMedCrossRefGoogle Scholar
  4. 4.
    Fietta A, Sacchi F, Bersani C, et al. (1987) Complement-dependent bactericidal activity for E. coli K12 in serum of preterm newborn infants. Acta Paediatr Scand 76:37–41PubMedCrossRefGoogle Scholar
  5. 5.
    Miyawaki T, Moriya N, Nagaoki T, Taniguchi N (1981) Maturation of B cell differentiation ability and T cell regulatory function in infancy and childhood. Immunol Rev 57:61–88PubMedCrossRefGoogle Scholar
  6. 6.
    Murgita A, Wigzell H (1981) Regulation of immune functions in the fetus and newborn. Prog Allergy 219:54–113Google Scholar
  7. 7.
    Roberton DM, Paganelli R, Dinwiddie R, Levinsky RJ (1982) Milk antigen absorption in the preterm and term neonate. Arch Dis Child 57:369–372PubMedCrossRefGoogle Scholar
  8. 8.
    Beach RC, Menzies IS, Clayden GS, Scopes JW (1982) Gastrointestinal permeability changes in the preterm neonate. Arch Dis Child 57:141–145PubMedCrossRefGoogle Scholar
  9. 9.
    Turner MW, Boulton P, Shields JG, et al. (1987) Uptake of ingested protein from the gut, changes in intestinal permeability to sugars and release of mast cell protease II in rats experiencing locally induced hypersensitivity reactions. In: Chandra RK (ed) Food allergy, St. Johns, Newfoundland, Nutrition Research Foundation, pp 79–94Google Scholar
  10. 10.
    Müller G, Bernsau I, Müller W, Weisbarth-Riedel E, Natzschka J, Rieger CHL (1987) Cow’s milk protein antigens and antibodies in the serum of premature infants during the first 10 days of life. J Pediatr 109:869–873Google Scholar
  11. 11.
    Lindberg T, Lothe L, Axelsson I, Benediktsson B (1986) Human alpha-lactalbumin as a marker of macromolecular absorption. Gut 27:1029–1034PubMedCrossRefGoogle Scholar
  12. 12.
    Ehrlich P (1892) Über Immunität durch Vererbung und Säugung, Zeitschr Hygiene und Infektionskrankheiten 12:183–203CrossRefGoogle Scholar
  13. 13.
    Ogra SS, Ogra PL (1978) Immunologie aspects of human colostrum and milk. II. Characteristics of lymphocyte reactivity and distribution of E-rosette forming cells at different times after onset of lactation. J Pediatr 92:550–554PubMedCrossRefGoogle Scholar
  14. 14.
    Hanson L, Ahlstedt S, Andersson B, et al. (1985) Protective factors in milk and the development of the immune system. Pediatrics 75 (suppl.): 172–175PubMedGoogle Scholar
  15. 15.
    Svanborg-Eden C, Carlsson B, Hanson L, et al. (1979) Anti-pili antibodies in breast milk. Lancet 2:1235CrossRefGoogle Scholar
  16. 16.
    Kilshaw PJ, Cant AJ (1984) The passage of maternal dietary proteins into human breast milk. Int Arch Allergy Appl Immunol 75:8PubMedCrossRefGoogle Scholar
  17. 17.
    Gerrard JW (1984) Allergies in breast fed babies to foods ingested by mothers. Clin Rev Allergy 2:143–149PubMedGoogle Scholar
  18. 18.
    Chandra RK, Puri S, Suraiya C, Cheema PS (1986) Influence of maternal food antigen avoidance during pregnancy and lactation on incidence of atopic eczema an infants. Clin Allergy 16:563–569PubMedCrossRefGoogle Scholar
  19. 19.
    Björksten B (1983) Does breast feeding prevent the development of allergy? Immunol Today 4:215–217CrossRefGoogle Scholar
  20. 20.
    Gillin FD, Reiner DS, Wang CS (1983) Human milk kills parasitic intestinal protozoa. Science 221:1290–1291PubMedCrossRefGoogle Scholar
  21. 21.
    Kramer MS (1988) Does breast feeding help protect against atopic disease — biology, methodology, and a golden jubilee of controversy. J Pediatr 112:182–190Google Scholar
  22. 22.
    Savilhati E, Tainio V-M, Salmenpera L, et al. (1987) Prolonged exclusive breast feeding and heredity as determinants in infantile atopy. Arch Dis Child 62:269–273CrossRefGoogle Scholar
  23. 23.
    Dannaeus A, Johannson SGO, Foucard T (1978) Clinical and immunological aspects of food allergy. II. Development of allergic symptoms and humoral immune response to foods in infants of atopic mothers during the first 24 months of life. Acta Paediatr Scand 67:715–718CrossRefGoogle Scholar
  24. 24.
    Harmatz PR, Bloch KJ, Kleinman RE, Walsh MK, Walker WA (1986) Influence of circulating maternal antibody on the transfer of dietary antigen to neonatal mice via milk. Immunology 57:43–48PubMedGoogle Scholar
  25. 25.
    Rieger CHL, Kraft SC, Rothberg RM (1980) Lack of effect of passive immunization on the active immune response to an ingested soluble protein antigen. J Immunol 124:1789–1793PubMedGoogle Scholar
  26. 26.
    Müller W, Lippmann A, Rieger CHL (1983) Oral immunization to milk protein in human infants in the presence of passive antibody. Pediatr Res 17:724–728PubMedCrossRefGoogle Scholar
  27. 27.
    Rothberg RM, Farr RS (1965) Anti bovine serum albumin and anti alpha lactalbumin in the sera of children and adults. Pediatrics 35:381–376Google Scholar
  28. 28.
    Rothberg RM, Rieger CHL, Silverman GA, Peri BA (1981) Antigen uptake and antibody production in the human newborn. In: Orgra PL, Bienenstock J (eds.) First Ross Conference. Ross Laboratories, Columbus 57–62Google Scholar
  29. 29.
    Jarrett EEE (1978) Stimuli for the production and control of IgE in rats. Immunol Rev 41:52–76PubMedCrossRefGoogle Scholar
  30. 30.
    Jarrett EEE, Hall E (1979) Selective suppression of IgE antibody responsiveness by maternal influence. Nature 280:145–147PubMedCrossRefGoogle Scholar
  31. 31.
    Jarrett EEE (1984) Perinatal influences on IgE responses. Lancet 2:797–799PubMedCrossRefGoogle Scholar
  32. 32.
    Mowat AM (1987) The regulation of immune responses to dietary proteins. Immunol Today 8:93–98CrossRefGoogle Scholar
  33. 33.
    Strober W (1982) The regulation of mucosal immune system. J Allergy Clin Immunol 70:225–230PubMedCrossRefGoogle Scholar
  34. 34.
    Strobel S, Mowat AM, Pickering MG, Fersuson A (1983) Immunological responses to fed proteins in mice. 2. Oral tolerance for CMI is due to activation of cyclophosphamide sensitive cells by gut processed antigen. Immunology 49:451–456PubMedGoogle Scholar
  35. 35.
    Vaz N, Maia L, Hanson DG, Lynch J (1977) Inhibition of homocytotropic antibody responses in adult inbred mice by previous feeding of the specific antigen. J Allergy Clin Immunol 60:110–115PubMedCrossRefGoogle Scholar
  36. 36.
    Korenblatt PE, Rothberg RM, Minden P, Farr PS (1968) Immune responses of human adults after oral and parenteral exposure to bovine serum albumin. J Allergy 41:226–235CrossRefGoogle Scholar
  37. 37.
    Lowney ED (1968) Immunologic unresponsiveness to a contact sensitiser in man. J Invest Dermatol 51:411–417PubMedGoogle Scholar
  38. 38.
    Lafont S, André C, Gillon J, Fargier MC (1982) Abrogation by subsequent feeding of antibody response, including IgE in parenterally immunized mice. J. Exp Med 152:1573–1578CrossRefGoogle Scholar
  39. 39.
    Strobel S (1984) Modulation of the immune response to fed antigen in mice. Ph.D thesis University of EdinburghGoogle Scholar
  40. 40.
    Strobel S, Ferguson A (1987) Persistence of oral tolerance in mice fed ovalbumin is different for humoral and cell mediated immune responses. Immunology 60:317–318PubMedGoogle Scholar
  41. 41.
    Parrott DMV (1976) The gut as a lymphoid organ. Clin Gastroenterol 5:211–228PubMedGoogle Scholar
  42. 42.
    Phillips-Quagliata JM, Roux ME, Amy M, et al. (1983) Migration and regulation of B-cells in the mucosal immune system. Ann NY Acad Sci 409:194–202PubMedCrossRefGoogle Scholar
  43. 43.
    Strober W, Richman LK, Elson CO (1981) The regulation of the gastrointestinal immune responses. Immunol Today 2:156–162CrossRefGoogle Scholar
  44. 44.
    Kilshaw PJ (1981) Gastrointestinal hypersensitivity in the preruminant calf. In: Bourne FJ (ed.) The mucosal immune system. The Hague, Nijhoff 203–219CrossRefGoogle Scholar
  45. 45.
    Stokes CR, Newby TJ, Bourne FJ (1983) The influence of oral immunization on local and systemic immune response to heterologous antigens. Clin Exp Immunol 52:399–406PubMedGoogle Scholar
  46. 46.
    Strobel S, Ferguson A (1984) Immune responses to fed antigen in mice. 3. Systemic tolerance or priming is related to age at which antigen is first encountered. Pediatr Res 18:588–594PubMedCrossRefGoogle Scholar
  47. 47.
    Strobel S, Ferguson A (1986) Modulation of intestinal and systemic immune responses to a fed protein antigen in mice. Gut 27:829–837PubMedCrossRefGoogle Scholar
  48. 48.
    Stein KE, Söderström T (1984) Neonatal administration of idiotypic or anti-idiotypic antibody primes for protection against Escherichia coli K13 infection in mice. J Exp Med 160:1001–1011PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • S. Strobel

There are no affiliations available

Personalised recommendations