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Mucosal Passage and Handling of Food-Protein Antigens

  • M. Stern
Conference paper

Abstract

The occurrence of cow’s milk allergy (CMA) was reported early in this century [29] as an example of food-protein allergy during early infancy in man. Using indirect immunological methods, different researchers demonstrated that food proteins in young infants were taken up either undigested [35] or incompletely digested [13]. For a long time after this early work, increased uptake of incompletely digested food protein material was thought to constitute the major pathogenetic factor in the development of food allergy. The results of animal studies and a few human studies have provided new insights into the complicated interrelation between mucosal barrier elements and the gut-associated lymphoid tissue (GALT) and into processes such as the mucosal handling and transmucosal passage of food proteins. Clinical methods have made possible the definition of the relative allergenic potential of single cow’s milk proteins (Table 1; for references see [29]).

Keywords

Food Allergy Food Protein Microvillus Membrane Pepsin Hydrolysis Major Pathogenetic Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Beach RC, Menzies IS, Clayden GS, Scopes JW (1982) Gastrointestinal permeability changes in the preterm neonate. Arch Dis Child 57:141–145PubMedCrossRefGoogle Scholar
  2. 2.
    Bock SA, Remigio LK, Gordon B (1983) Immunochemical localization of proteins in the intestinal mucosa of children with diarrhea. J Allergy Clin Immunol 72:262–268PubMedCrossRefGoogle Scholar
  3. 3.
    Dannaeus A, Inganvs M, Johansson SGO, Foucard T (1979) Intestinal uptake of ovalbumin in malabsorption and food allergy in relation to serum IgG antibody and orally administered sodium cromoglycate. Clin Allergy 9:263–270PubMedCrossRefGoogle Scholar
  4. 4.
    Ferguson TA, Peters T, Reed R, Pesce AJ, Michael JG (1983) Immunoregulatory properties of antigenic fragments from bovine serum albumin. Cell Immunol 78:1–12PubMedCrossRefGoogle Scholar
  5. 5.
    Forstner GG, Forstner JE (1981) Mucosal barrier and its defense mechanisms during the perinatal period. In: Lebenthal E (ed) Textbook of gastroenterology and nutrition in infancy. Raven, New York, pp 201–210Google Scholar
  6. 6.
    Gardner MLG, Lindblad BS, Burston D, Matthews DM (1983) Trans-mucosal passage of intact peptides in the guinea-pig small intestine in vivo: a reappraisal. Clin Soc 64:433–439Google Scholar
  7. 7.
    Haddad ZH, Kalra V, Verma S (1979) IgE antibodies to peptic and peptic-tryptic digests of beta-lactoglobulin: significance in food hypersensitivity. Ann Allergy 42:395–396Google Scholar
  8. 8.
    Henning SJ (1981) Postnatal development: coordination of feeding, digestion, and metabolism. Am J Physiol 241:G199–214Google Scholar
  9. 9.
    Heyman M, Boudraa G, Sarrut S, Giraud M, Evans L, Touhami M, Desjeux JF (1984) Macromolecular transport in jejunal mucosa of children with severe malnutrition: a quantitative study. J Pediatr Gastroenterol Nutr 3:357–363PubMedCrossRefGoogle Scholar
  10. 10.
    Jakobsson I, Lindberg T, Lothe L, Axelsson I, Benediktsson B (1986) Human alpha-lactalbumin as a marker of macromolecular absorption. Gut 27:1029–1034PubMedCrossRefGoogle Scholar
  11. 11.
    Kilshaw PJ, Slade H (1980) Passage of ingested protein into the blood during gastrointestinal hypersensitivity reactions: experiments in te preruminant calf. Clin Exp Immunol 41:575–582PubMedGoogle Scholar
  12. 12.
    Koritz TN, Suzuki S, Coombs RRA (1987) Antigenic stimulation with proteins of cow’s milk via the oral route in guinea pigs and rats. I. Measurement of antigenically intact beta-lactoglobulin and casein in the gastrointestinal contents of duodenum, jejunum and ileum. Int Arch Allergy Appl Immunol 82:72–75PubMedCrossRefGoogle Scholar
  13. 13.
    Lippard VW, Schloss OM, Johnson PA (1936) Immune reactions induced in infants by intestinal absorption of incompletely digested cow’s milk protein. Am J Dis Child 51:562–574Google Scholar
  14. 14.
    Muckerheide A, Pesce AJ, Michael JG (1977) Immunosuppressive properties of a peptic fragment of BSA. J Immunol 119:1340–1345PubMedGoogle Scholar
  15. 15.
    Müller G, Bernsau I, Müller W, Weissbarth-Riedel E, Natzschka J, Rieger CHL (1986) Cow milk protein antigens and antibodies in serum of premature infants during the first 10 days of life. J Pediatr 109:869–873PubMedCrossRefGoogle Scholar
  16. 16.
    Owen RL (1977) Sequential uptake of horseradish peroxidase by lympohoid follicle epoithelium of Peyer’s patches in the normal unobstructed mouse intestine: an ultrastructural study. Gastroenterology 72:440–451PubMedGoogle Scholar
  17. 17.
    Pang KY, Bresson JL, Walker WA (1983) Development of the gastrointestinal mucosal barrier. Evidence for structural differences in microvillus membranes from newborn and adult rabbits. Biochim Biophys Acta 727:201–208PubMedCrossRefGoogle Scholar
  18. 18.
    Pearson JR, Kingston D, Shiner M (1983) Antibody production to milk proteins in the jejunal mucosa of children with cow’s milk protein intolerance. Pediatr Res 17:406–412PubMedCrossRefGoogle Scholar
  19. 19.
    Reinhardt MC, Paganelli R, Levinsky R (1983) Intestinal antigen handling at mucosal surfaces in health and disease: human and experimental studies. Ann Allergy 51:311–314PubMedGoogle Scholar
  20. 20.
    Roberton DM, Paganelli R, Dinwiddie R et al. (1982) Milk antigen absorption in the preterm and term neonate. Arch Dis Child 57:372CrossRefGoogle Scholar
  21. 21.
    Roberts SA, Reinhardt MC, Paganelli R et al. (1981) Specific antigen exclusion and nonspecific facilitation of antigen entry across the gut in rats allergic to food proteins. Clin Exp Immunol 45:131–136PubMedGoogle Scholar
  22. 22.
    Schwartz HR, Neruskar LS, Spies JR et al. (1980) Milk hypersensitivity: RAST studies using new antigens generated by pepsin hydrolysis of beta-lactoglobulin. Ann Allergy 45:242–245PubMedGoogle Scholar
  23. 23.
    Shub MD, Pang KY, Swann DA, Walker WA (1983) Age-related changes in chemical composition and physical properties of mucus glycoporoteins from rat small intestine. Biochem J 215:405–411PubMedGoogle Scholar
  24. 24.
    Sissons JW, Thurston SM (1984) Survival of dietary antigens in the digestive tract of calves intolerant to soyabean products. Res Vet Sci 37:242–246PubMedGoogle Scholar
  25. 25.
    Skogh T, Edebo L, Stendahl O (1983) Gastrointestinal uptake and blood clearance of antigen in the presence of IgA antibodies. Immunology 50:175–180PubMedGoogle Scholar
  26. 26.
    Spies JR, Stevan MA, Stein WJ et al. (1970) The chemistry of allergens. XX. New antigens generated by pepsin hydrolysis of bovine milk proteins. J Allergy 45:208–219CrossRefGoogle Scholar
  27. 27.
    Stern M, Walker WA (1984) Food proteins and gut mucosal barrier. I. Binding and uptake of cow’s milk proteins by adult rat jejenum in vitro. Am J Physiol 246:G556–G562PubMedGoogle Scholar
  28. 28.
    Stern M, Pang KY, Walker WA (1984) Food proteins and gut mucosal barrier. II. Differential interaction of cow’s milk proteins with the mucous coat and the surface membrane of adult and immature rat jejunum. Pediatr Res 18:1252–1256PubMedCrossRefGoogle Scholar
  29. 29.
    Stern M, Walker WA (1985) Food allergy and intolerance. Pediatr Clin North Am 32:471–492PubMedGoogle Scholar
  30. 30.
    Stern M, Gellermann B (1989) Food proteins and maturation of small intestinal microvillus membranes (MVM). I. Binding characteristics of cow’s milk proteins and concanavalin A to MVM from newborn and adult rats. J Pediatr Gastroenterol Nutr 7:115–121CrossRefGoogle Scholar
  31. 31.
    Udall JN, Pang K, Fritze L et al. (1981) Development of gastrointestinal musosal barrier. I. The effect of age on intestinal permeability to macromolecules. Pediatr Res 15:241–244PubMedGoogle Scholar
  32. 32.
    Walker WA (1987) Transmucosal passage of antigens. In: Reinhardt E, Schmidt E (eds) Food allergy. Raven, New York, pp 15–34Google Scholar
  33. 33.
    Weaver LT, Koritz TN, Coombs RRA (1987) Tolerance to orally induced anaphylactic sensitisation to cow’s milk proteins and patency of the intestinal mucosa in the neonatal guinea pig. Int Arch Allergy Appl Immunol 83:220–222PubMedCrossRefGoogle Scholar
  34. 34.
    Weström B, Svendsen J, Tagesson C (1984) Intestinal permeability to polyethyleneglycol 600 in relation to macromolecular closure in the neonatal pig. Gut 25:520–525PubMedCrossRefGoogle Scholar
  35. 35.
    Wilson SJ, Walzer M (1935) Absorption of undigested proteins in human beings. IV. Absorption of unaltered egg protein in infants and in children. Am J Dis Child 50:49–54Google Scholar
  36. 36.
    Wright RN, Rothberg R (1971) The reactions of pepsin and pepsin-trypsin digestion products of bovine serum albumin with antisera from rabbits ingesting this protein. J Immunol 107:1410–1418PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1989

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  • M. Stern

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