How Allergenic are “Hypoallergenic” Formulas?
Immediate hypersensitivity reactions to cow’s milk proteins can often be found in early childhood [3–5, 7, 11]. Cow’s milk is the first proteinrich food that most infants receive after weaning. All the known antigens of cow’s milk are Proteins (Table 1). Cow’s milk contains more than 25 distinct proteins that may act as antigens in man [1, 2, 6]. The most important allergens are casein and the whey proteins β-lactoglobulin, α-lactalbumin, bovine serum albumin (BSA) and immunoglobulin. Some 60%-80% of milk-allergic patients have serum IgE to β-lactoglobulin, 60% to casein, 50% to α-lactalbumin and BSA, and up to 40% to immunoglobulin [1, 2].
KeywordsAtopic Eczema Food Allergy Whey Protein Histamine Release Allergy Clin Immunol
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Aas K (1976) Common characteristics of major allergens. In: Johannsson SGO, Strandberg K (eds) Molecular and biological aspects of the acute allergic reaction. Plenum, New York, pp 3–19CrossRefGoogle Scholar
Aas K (1978) What makes an allergen an allergen? Allergy 33:3–14PubMedCrossRefGoogle Scholar
Anderson JA, Sogn DD (eds) (1984) Adverse reactions to foods. AAAI and NIAID Report, NIH Publication no 84-2442Google Scholar
Bock SA (1982) The natural history of food sensitivity. J Allergy Clin Immunol 69:173–177PubMedCrossRefGoogle Scholar
Businco L, Benincori N, Cantani A (1984) Epidemiology, incidence and clinical aspects of food allergy. Ann Allergy 53:615–622PubMedGoogle Scholar
Gjesing B, Lowenstein H (1984) Immunochemistry of food antigens. Ann Allergy 53: 602PubMedGoogle Scholar
Hattevig G, Kjellman B, Johannsson SGO, Björksten B (1984) Clinical symptoms and IgE responses to common food proteins in atopic and healthy children. Clin Allergy 14:559Google Scholar
Hill DJ, Davidson GP, Cameron DJS, Barnes GL (1979) The spectrum of cow’s milk allergy in childhood. Acta Paediatr Scand 68:847–852PubMedCrossRefGoogle Scholar
King TP (1976) Chemical and biological properties of some atopic allergens. Adv Immunol 23:77–105PubMedCrossRefGoogle Scholar
Rimmer J, Bryant DH (1986) Effect of hypo-and hyper-osmolarity on basophil histamine release. Clin Allergy 16:221–230PubMedCrossRefGoogle Scholar
Sampson HA (1983) Role of immediate hypersensitivity in the pathogenesis of atopic dermatitis. J Allergy Clin Immunol 71(5): 473–480PubMedCrossRefGoogle Scholar
Siraganian R (1974) An automated continuous flow system for the extraction and fluorometric analysis of histamine. Anal Biochem 57:383PubMedCrossRefGoogle Scholar
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