Modifications of Intestinal Permeability to Large Molecules During Oral Provocation Tests in Children with Cow’s Milk Sensitive Enteropathy and Atopic Dermatitis

  • C. Dupont
  • E. Barau
  • P. Molkhou
Conference paper


The gut is characterized by a certain degree of leakiness, as a result of which molecules and macromolecules that are not actively absorbed may permeate passively through the intestinal wall. The degree of leakiness in, or rate of permeation across, the intestinal wall depends upon many factors, including the size of the molecule and the state of the mucosa [9, 15]. Practical methods to measure this permeability of the mucosa to molecules and macromolecules have been developed, based on measurement of the urinary excretion of orally absorbed non-meta-bolizable markers. The use of two probe molecules of different molecular sizes, such as mannitol and lactulose, exploits the principle of differential absorption, namely that the two markers behave similarly in all respects except in their rate of permeation across the mucosa. Expressing the relative rates of urinary excretion of the markers as a ratio thus allows the researcher to overcome the effects of the many non-relevant variables that may influence individual markers [10] and to compare results of repeat procedures performed under different clinical conditions. The aim of this study was to use a non-invasive technique to detect the food-induced alterations of mucosal integrity under conditions of cow’s milk protein sensitive enteropathy (CMPSE) and atopic dermatitis (AD). The relationships of these conditions to food allergy, although still controversial, have been widely substantiated [2, 4, 13, 17, 20, 22].


Celiac Disease Food Allergy Coeliac Disease Intestinal Permeability Sodium Cromoglycate 
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© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • C. Dupont
  • E. Barau
  • P. Molkhou

There are no affiliations available

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