Potentials of Magnetic Resonance Spectroscopy in Neuroradiology
Magnetic resonance refers to the ability of nuclei with a nonzero spin to undergo processing proportional to an external magnetic field. Two different applications of this physical phenomenon exist: magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). In MRI, differences of the resonance frequency reflect mainly the position of the atoms in space, depending on the use of magnetic gradients, as experimentally demonstrated by Lauterbur in 1973. The hydrogen atom, by far the most common atom in living organisms, permits MRI with high spatial resolution and excellent soft-tissue contrast. Proton MRI has been developed into a routine diagnostic modality in neuroradiology with high sensitivity, but it still has limited specificity. Much interest is therefore now directed to MRS which, on the basis of experimental results in animal studies and human muscle disorders (Radda 1986), promises the introduction of biochemical information into clinical neuroradiology.
KeywordsMagnetic Resonance Spectroscopy Mitochondrial Myopathy Frontal White Matter Magnetic Gradient Proton Nuclear Magnetic Resonance Spectrum
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