Potentials of Magnetic Resonance Spectroscopy in Neuroradiology

  • S. Felber
  • R. Sauter
  • W. Löffler
Conference paper


Magnetic resonance refers to the ability of nuclei with a nonzero spin to undergo processing proportional to an external magnetic field. Two different applications of this physical phenomenon exist: magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). In MRI, differences of the resonance frequency reflect mainly the position of the atoms in space, depending on the use of magnetic gradients, as experimentally demonstrated by Lauterbur in 1973. The hydrogen atom, by far the most common atom in living organisms, permits MRI with high spatial resolution and excellent soft-tissue contrast. Proton MRI has been developed into a routine diagnostic modality in neuroradiology with high sensitivity, but it still has limited specificity. Much interest is therefore now directed to MRS which, on the basis of experimental results in animal studies and human muscle disorders (Radda 1986), promises the introduction of biochemical information into clinical neuroradiology.


Magnetic Resonance Spectroscopy Mitochondrial Myopathy Frontal White Matter Magnetic Gradient Proton Nuclear Magnetic Resonance Spectrum 
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  1. [1]
    Argov Z, Bank WJ, Maris J, Peterson P, Chance B (1987) Bio-energetic heterogeneity of human mitochondrial myopathies: phosphorus magnetic resonance study. Neurology 37: 257–262PubMedCrossRefGoogle Scholar
  2. [2]
    Aue WP (1986) Localisation methods for in vivo nuclear magnetic resonance spectroscopy. Rev Magn Reson Med 1: 12–72Google Scholar
  3. [3]
    Bottomley PA, Drayer BP, Smith LS (1986) Chronic adult cerebral infarction studied by phosphorus NMR spectroscopy. Radiology 160: 763–766PubMedGoogle Scholar
  4. [4]
    Bruhn H, Frahm J, Gyngell ML, Merboldt KD, Hänicke W, Sauter R (1988) Localized proton spectroscopy of tumours in vivo: patients with primary and secondary cerebral tumours. In: Abstracts of 7th annual meeting, Society of Magnetic Resonance in Medicine 1: 253Google Scholar
  5. [5]
    Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hänicke W. Sauter R (1988) Localized high resolution proton NMR spectros-copy using stimulated echoes. Initial application to human brain in vivo. Magn Reson Med (submitted)Google Scholar
  6. [6]
    Hollander JA den, Luyten PR (1986) P and H spectroscopy on a whole body MR scanner. Medicamundi 31 (2): 64–67Google Scholar
  7. [7]
    Hope PL, Costello AM, Cady EB et al. (1984) Cerebral energy metabolism studied with phosphor NMR spectroscopy in normal and birth asphyxiated infants. Lancet 2: 366–370PubMedCrossRefGoogle Scholar
  8. [8]
    Lanterbur PC (1973) Image formation by induced local interactions: examples employing nuclear magnetic resonance. Nature 242: 190–191CrossRefGoogle Scholar
  9. [9]
    Luyten PR, den Hollander JA (1986) Observation of metaboli-ties in the human brain by MR spectroscopy. Radiology 161: 795–798PubMedGoogle Scholar
  10. [10]
    Perman WH, Turski PA, Houston LW, Glover GH, Hayes CE (1986) Methodology of in vivo human sodium MR imaging at 1.5 T. Radiology 160: 811–820PubMedGoogle Scholar
  11. [11]
    Radda GK (1986) The use of NMR spectroscopy for the understanding of disease. Science 233: 640–645PubMedCrossRefGoogle Scholar
  12. [12]
    Requard H, Offermann J, Sauter R (1988) Radiology (submitted)Google Scholar
  13. [13]
    Sauter R, Mueller S, Weber H (1987) Localisation in in vivo P NMR spectroscopy by combining surface coils and slice-selective saturation. J Magn Reson 75 (1): 167–173 [14] Segebarth CM, Baleriaux DF, Arnold DL, Luyten PR, Hollander JA den (1987) MR-image-guided 31P MR spectroscopy in the evaluation of brain tumor treatment. Radiology 165: 215-219Google Scholar
  14. [15]
    Semmler W, Gademann G, Kaick G v, Zabel HJ, Lorenz WJ (1986) In vivo P spectroscopy of human tumors and their response to therapy using a 1.5 T whole body scanner. In: Abstracts of 5th annual meeting, Society of Magnetic Resonance in Medicine 1: 39Google Scholar
  15. [16]
    Tanaka C, Naruse S, Horikawa Y, Hirakawa K, Yoshizaki K, Nishikawa H (1986) Proton nuclear magnetic resonance spectra of brain tumors. Magn Reson Imaging 4: 503–508CrossRefGoogle Scholar
  16. [17]
    Wolf W, Albright J, Silver MS, Weber H, Reichardt U, Sauer R (1987) Fluorine 19 NMR spectroscopic studies of the metabolism of 5-fluorouracil in the liver of patients undergoing chemotherapy. Magn Reson Imaging 5: 165–169PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • S. Felber
  • R. Sauter
  • W. Löffler

There are no affiliations available

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