Skip to main content
  • 82 Accesses

Abstract

The compound coded B-19036, an octadentate chelate of the paramagnetic ion Gd3+ (3, 6 ,9-triaza-12-oxa-3, 6, 9-tricarboxymethylene -10-carboxy-13-phenyl-tridecanoic acid, gadolinium chelate, Fig. 1), is a new contrast agent for magnetic resonance imaging, developed in our laboratories (Felder et al. 1985). Systemic and neural tolerance for B-19036 was evaluated both after intravenous and intrathecal administration.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Corsico N, Tirone P (1987) EEG studies in the conscious unrestrained rat: a tool for the study of immediate and delayed neurotoxicity of contrasts media. In: Calabrò A, Leonardi M (eds) Computer Aided Neuroradiology p 255–258

    Google Scholar 

  • Felder E et al. (1985) Bracco Industria Chimica EP Patent application n. 230893

    Google Scholar 

  • Irwin S (1968) Comprehensive observational assessement: Ia-A systematic quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacologia 13, 222–236

    Article  CAS  PubMed  Google Scholar 

  • Litchfield Jr J T, Wilcoxon F (1949) A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Therap 96, 99–113

    CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Corsico, N., Tirone, P. (1989). Neurophysiologic Assessment of Neural Tolerance of a New Paramagnetic Complex. In: Nadjmi, M. (eds) Imaging of Brain Metabolism Spine and Cord Interventional Neuroradiology Free Communications. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74337-5_167

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-74337-5_167

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74339-9

  • Online ISBN: 978-3-642-74337-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics