Neurophysiologic Assessment of Neural Tolerance of a New Paramagnetic Complex
The compound coded B-19036, an octadentate chelate of the paramagnetic ion Gd3+ (3, 6 ,9-triaza-12-oxa-3, 6, 9-tricarboxymethylene -10-carboxy-13-phenyl-tridecanoic acid, gadolinium chelate, Fig. 1), is a new contrast agent for magnetic resonance imaging, developed in our laboratories (Felder et al. 1985). Systemic and neural tolerance for B-19036 was evaluated both after intravenous and intrathecal administration.
KeywordsPermeability Toxicity Gadolinium Neurotoxicity Meglumine
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