Artificial Cerebrovascular Infarction in Baboons — A New Technique Using an Endovascular Approach
Transorbital occlusion of the middle cerebral artery (MCA) has been used to provoke focal cerebral ischemia in monkeys (Hartmann et al. 1981; Del Zoppo et al. 1986; Symon et al. 1979), cats (Shigeno et al. 1985, Rosner et al. 1986) and other animals (Fein and Molinari 1976). This approach was first described by Hudgins and Garcia 1970 for rhesus monkeys and by O’Brien and Waltz 1973 for cats and superceded the retroorbital approach as described by Sundt and Waltz 1966. The transorbital approach with either clipping or ligation of the MCA has been used in our laboratory for several years and has been proven to produce cerebral ischemia and cerebral infarction (Hartmann et al. 1982, Barbosa-Coutinho et al. 1985).
KeywordsCatheter Ischemia Torque Dexamethasone Neurol
Unable to display preview. Download preview PDF.
- Barbosa-Coutinho LM, Hartmann A, Hossmann KA,. Rommel T (1985) Effect of dexamethasone on serum protein extravasation in experimental brain infarcts to monkeys. An immunohistochemical study. Acta Neuropathol, Berlin 65:255–260Google Scholar
- Diaz FG, Ausman JI (1980) Experimental cerebral ischemia. Neurosurg. 6:36–445Google Scholar
- Dujovny M, Barrioneuva PJ, Laha RK, Osgood CP, De Castro S, Maroon J, Hellstrom R (1976) Experimental middle cerebral artery microsurgical embolectomy. Microsurgery for Stroke, edited by Schmiedeck P, New York, Springer Verlag: 91–97.Google Scholar
- Fein JM, Molinari G (1976) Hemodynamic evaluation of superficial tem-poral cortical artery microanastomosis in the dog. Microneurosurgical Anastomosis for Cerebral Ischemia, edited by Austin GM, Springfield, Illinois, Charles C. Thomas:5–14Google Scholar
- Hartmann A, Menzel J, Lange D, Buttinger C (1983) An experimental primate stroke model to study cerebrovascular responses to chronic cerebral ischemia. Advances Biosciences 43:167–183Google Scholar
- Molinari GF, Moseley JI, Laurent JP (1974) Segmental middle cerebral artery occlusion in primates. An experimental method requiring minimal surgery and anesthesia. Stroke 5:334–339Google Scholar
- O’Brien M, Waltz AG (1972) Changes of intracranial pressure during experimental cerebral infarction. Proc. 1st Int. Symp. on Intra-cranial Pressure HannoverGoogle Scholar
- Symon L, Pasztor E, Branston NM (1974) The distribution and density of reduced cerebral blood flow following acute middle cerebral artery occlusion. An experimental study by the technique of hydrogen clearance in baboons. Stroke 5:355–364Google Scholar
- Symon L, Branston NM, Chikovani O (1979) Ischemic brain edema following middle cerebral artery occlusion in baboons. Relationship between regional, cerebral water content and blood flow at 1 to 2 hours. Stroke 10:184–191Google Scholar