Sensitization of the Adrenergic System in Early Myocardial Ischemia: Independent Regulation of β-Adrenergic Receptors and Adenylate Cyclase

  • R. H. Strasser
  • R. Marquetant
  • W. Kübler
Conference paper


The dynamic regulation of the adrenergic system plays an important role in the adaptation of the cardiovascular system both in health and in disease. In disease, presynaptic mechanisms involved in the release of catecholamines and/or post-synaptic mechanisms involved in adrenergic transmission to the cell might be altered. In acute myocardial ischemia, large quantities of catecholamines are presynaptically released [1–5]. These catecholamines activate postsynaptically adrenergic and especially β-adrenergic receptors [6–8]. But, as shown in many tissues [6, 9–12] including heart [13,14], agonist occupancy of β-adrenergic receptors also leads to unresponsiveness to further stimulation, a phenomenon called tachyphylaxis or desensitization.


Adenylate Cyclase Adrenergic Receptor Adenylate Cyclase Activity Global Ischemia Adrenergic System 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • R. H. Strasser
  • R. Marquetant
  • W. Kübler

There are no affiliations available

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