Towards a New Dimension of Cardiac Cellular Electrophysiology — General Aspects
It is now nearly 40 years since the first successful attempts were made to record cardiac cellular resting and action potentials by means of intracellular microelectrodes [1, 2]. However, the results obtained during early years, although of considerable fundamental significance, were not able to explain many familiar pathophysiological phenomena. Bridges between basic electrophysiology and clinical practice scarcely existed before the mid — 1960s but have been growing rapidly ever since. This is impressively reflected by a great number of monographs and review articles dealing with basic electrophysiological aspects of disturbances in cardiac excitation. An up-to-date report on the state of knowledge concerning disturbances in ionic equilibria that accompany myocardial ischemia is given by Kleber et al. (this volume). There it is clearly demonstrated to what extent changes of the intracellular and extracellular ionic concentrations interfere with the excitatory phenomena under such conditions.
KeywordsSingle Channel Purkinje Fibre Single Channel Current Single Channel Recording Cardiac Excitation
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- 1.Coraboeuf E, Weidmann S (1949) Potentiels d’action due muscle cardiaque obtenus a l’aide de microelectrodes intracellulaires. C R Acad Sci [III] 143:1360–1361.Google Scholar
- 5.Noble D (1984) The surprising heart. A review of recent progress in cardiac electrophysiology. J Physiol (Lond) 353:1–50.Google Scholar
- 6.Hille B (1984) Ionic channels of excitable membranes, 1st edn. Sinauer, Sunderland, MA.Google Scholar
- 7.Noda M, Shimizu S, Tanabe T, Takai T, Kayano T, Ikeda T, Takahashi H, Nakayama H, Kanaoka Y, Minamino N, Kangawa K, Matso H, Raftery MA, Hirose T, Inayama S, Hayashida H, Miyata T, Numa S (1984) Primary structure of electrophorus electricus sodium channel deduced from cDNA sequence. Nature 312:121–127.PubMedCrossRefGoogle Scholar
- 9.Ritchie JM, Keynes RD, Bolis L (1986) Ion channels in neural membranes. Liss, New York.Google Scholar
- 12.Colquhoun D, Hawkes AG (1983) The principles of the stochastic interpretation of ionchannel mechanisms. In: Sackman B, Neher E (eds) Single channel recording, Chap 9. Plenum, New York, pp 135–175.Google Scholar
- 13.Hesse P, Lansman JB, Nilius B, Tsien RW (1986) Calcium channel types in cardiac myocytes: modulation by dihydropyridines and β-adrenergic stimulation. J Cardiovasc Pharmacol 8 (Suppl):11–21.Google Scholar
- 16.Benoit E, Corbier A, Dubois JM (1985) Evidence for two transient sodium currents in the frog node of Ranvier. J Physiol (Lond) 361:339–360.Google Scholar
- 18.Eisner DA, Lederer WJ (1980) Characterization of the electrogenic sodium pump in cardiac Purkinje fibres. J Physiol (Lond) 303:441–474.Google Scholar
- 20.Hume JR (1989) Properties of myocardial K+ channels and their pharmacological modulation. In: Hondeghem LM (ed) Molecular and cellular mechanisms of antiarrhythmic agents. Futura, New York (in press).Google Scholar