Towards a New Dimension of Cardiac Cellular Electrophysiology — General Aspects
It is now nearly 40 years since the first successful attempts were made to record cardiac cellular resting and action potentials by means of intracellular microelectrodes [1, 2]. However, the results obtained during early years, although of considerable fundamental significance, were not able to explain many familiar pathophysiological phenomena. Bridges between basic electrophysiology and clinical practice scarcely existed before the mid — 1960s but have been growing rapidly ever since. This is impressively reflected by a great number of monographs and review articles dealing with basic electrophysiological aspects of disturbances in cardiac excitation. An up-to-date report on the state of knowledge concerning disturbances in ionic equilibria that accompany myocardial ischemia is given by Kleber et al. (this volume). There it is clearly demonstrated to what extent changes of the intracellular and extracellular ionic concentrations interfere with the excitatory phenomena under such conditions.
KeywordsPermeability Hydration Ischemia Polypeptide Acetylcholine
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