Persistent Maleic Acid Irritant Dermatitis in the Guinea Pig

  • R. L. Rietschel
Conference paper


Repeated exposure of guinea pig skin to maleic acid over a period of 8 months did not result in substantial irritant accommodation. Induction of dinitrochlorobenzene sensitivity was not facilitated by maleic acid irritant dermatitis but rather diminished. Chronically irritated guinea pig skin was acanthotic and showed hypergranulosis. Langerhans cell morphology was slightly altered with shorter and less numerous dendrites.

Key words

Maleic acid Irritant Guinea pig 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • R. L. Rietschel
    • 1
  1. 1.Department of DermatologyOchsner Clinic and Alton Ochsner Medical FoundationNew OrleansUSA

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