Persistent Maleic Acid Irritant Dermatitis in the Guinea Pig
Repeated exposure of guinea pig skin to maleic acid over a period of 8 months did not result in substantial irritant accommodation. Induction of dinitrochlorobenzene sensitivity was not facilitated by maleic acid irritant dermatitis but rather diminished. Chronically irritated guinea pig skin was acanthotic and showed hypergranulosis. Langerhans cell morphology was slightly altered with shorter and less numerous dendrites.
Key wordsMaleic acid Irritant Guinea pig
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