Allergic Contact Dermatitis from Isocyanates

  • L. Kanerva
  • M.-T. Lähteenmäki
  • T. Estlander
  • R. Jolanki
  • H. Keskinen


An allergological examination, including prick tests, scratch chamber tests, patch tests, and RAST tests, was performed in 83 consecutive patients exposed to isocyanates. Three cases of allergic contact dermatitis from isocyanates have been detected: the first patient was allergic to isophorone diisocyanate and trimethyl hexamethylene diisocyanate, the second to 4,4′-diphenylmethane diisocyanate (MDI) and toluene 2,4-diisocyanate (TDI), and the third to HDI and its prepolymer Desmodur-N. To our knowledge, this was the first patient reported to have allergic contact dermatitis from HDL The optimal patch test concentrations were 2%–5% in petrolatum for TDI and MDI, and 0.1%–0.2% in petrolatum for HDI, whereas 0.5% was irritant.

Key words

Epicutaneous test Occupation Allergic rhinitis Asthma Scratch chamber test 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • L. Kanerva
    • 1
  • M.-T. Lähteenmäki
    • 1
  • T. Estlander
    • 1
  • R. Jolanki
    • 1
  • H. Keskinen
    • 1
  1. 1.Section of DermatologyInstitute of Occupational HealthHelsinkiFinland

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