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Preliminary Findings on the Patterns of Epidermal Damage Induced by Irritants in Man

  • C. M. Willis
  • C. J. M. Stephens
  • J. D. Wilkinson

Summary

The histopathology of the primary irritant reactions induced after 48 h in human volunteers by benzalkonium chloride, sodium lauryl sulphate, croton oil, nonanoic acid, dithranol, and propylene glycol has been investigated. Patterns of epidermal damage were identified for each irritant, reflecting their differing chemical interactions with the cellular components of the skin.

Key words

Irritant contact dermatitis Histopathology 

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References

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    Swanbeck G, Liden S (1966) The inhibitary effect of dithranol (anthralin) on DNA synthesis. Acta Derm Venereol 46: 228.PubMedGoogle Scholar
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    Willis CM et al. (1986) Immunopathological and ultrastructural findings in human allergic and irritant contact dermatitis. Br J Dermatol 115: 305–316.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • C. M. Willis
    • 1
  • C. J. M. Stephens
    • 1
  • J. D. Wilkinson
    • 1
  1. 1.Department of DermatologyWycombe General HospitalBuckinghamshireUK

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