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Comparative Patch Testing with PPD-Base and PPD-Dihydrochloride: Human and Animal Data Compiled by the European Environmental Contact Dermatitis Research Group

  • A. Dooms-Goossens
  • R. J. Scheper
  • K. E. Andersen
  • D. Burrows
  • J. G. Camarasa
  • P. J. Frosch
  • A. Lahti
  • J. Wilkinson

Summary

The replacement of PPD-base 1% petrolatum (pet.) by PPD-dihydrochloride 0.5% pet. in the ICDRG standard series in 1984 seems to have reduced considerably the number of positive reactions to PPD. Therefore, the EECDRG decided to perform comparative patch tests with PPD-base and PPD-dihydrochloride. The results in human testing showed that most of the PPD sensitivities were missed by the PPD-dihydrochloride. Guinea pig experiments confirmed that PPD-dihydrochloride was less able to elicit hypersensitivity reactions than PPD-base. Similar results were obtained with groups of guinea pigs sensitized by intradermal injection to either allergen preparation. The difference in molecular weights, different liabilities in oxidative degradation to the sensitizing intermediate, or different skin penetration capabilities may account for this phenomenon.

Key words

Contact dermatitis PPD-base PPD-dihydrochloride Paraphenylenediamine False-negative reactions 

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References

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    Schmidt RJ, Fernandez de Corres L (1987) Allergic contact dermatitis from proprietary topical analgesic sprays containing 32-(aminomethyl)-pyridyl salicylate. Dermatologica 174: 272–279.PubMedCrossRefGoogle Scholar
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    Bronaugh RL, Congdon ER (1984) Percutaneous absorption of hair dyes: correlation with partition coefficients. J Invest Dermatol 83: 124–127.PubMedCrossRefGoogle Scholar
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    Storrs FJ, Taylor J, Jordan WP, Maibach HI (1979) Paraphenylenediamine hydrochloride. Contact Dermatitis 5: 126.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • A. Dooms-Goossens
    • 1
  • R. J. Scheper
    • 2
  • K. E. Andersen
    • 3
  • D. Burrows
    • 4
  • J. G. Camarasa
    • 5
  • P. J. Frosch
    • 6
  • A. Lahti
    • 7
  • J. Wilkinson
    • 8
  1. 1.Department of Medical Research (Dermatology)University HospitalLeuvenBelgium
  2. 2.Department of PathologyFree University HospitalAmsterdamThe Netherlands
  3. 3.HudklinikkenRoskildeDenmark
  4. 4.Department of DermatologyRoyal Victoria HospitalBelfastIreland
  5. 5.Department of DermatologyUniversitat Autónoma de BarcelonaSpain
  6. 6.Universitäts-HautklinikHeidelbergGermany
  7. 7.Department of DermatologyUniversity of OuloOuloFinland
  8. 8.Department of DermatologyWycombe General HospitalHigh WycombeEngland

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