Acute Generalized Dermatitis to Orally Administered Disulfiram

  • E. van Hecke
Conference paper


A severe reaction with an urticarial as well as an eczematous aspect is described after intake of 400 mg disulfiram on 2 consecutive days. The patient had a disulfiram implant 4 years ago.

Key words

Disulfiram Antabuse Systemic eczematous contact dermatitis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Hald J, Jacobsen E (1948) A drug sensitizing the organism to ethylalcohol. Lancet255: 1001–1004.CrossRefGoogle Scholar
  2. 2.
    Kaaber K, Menne T, Tjell JC, Veien N (1979) Antabuse treatment of nickel dermatitis. Contact Dermatitis 5:221–228.PubMedCrossRefGoogle Scholar
  3. 3.
    Lachapelle JM (1975) Allergic “contact” dermatitis from disulfiram implants. Contact Dermatitis 1:218–220.PubMedCrossRefGoogle Scholar
  4. 4.
    Malcolm MT, Madden JS, Williams AE (1974) Disulfiram implantation critically evaluated. Br J Psychiatry 124: 485–490.CrossRefGoogle Scholar
  5. 5.
    Pirilä V (1957) Dermatitis due to rubber. In: Proceedings 11th International Congress of Dermatology, vol 2, pp 252-255.Google Scholar
  6. 6.
    Raby K (1954) Relation of blood acetaldehyde levels to clinical symptoms in the disuLfiram-alcohol reaction. J Stud Alcohol 15: 21–32.Google Scholar
  7. 7.
    Van Ketel WG (1968) Rubber, alcohol and eczema. Dermatologica 136: 442–444.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • E. van Hecke
    • 1
  1. 1.Department of DermatologyUniversity HospitalGentBelgium

Personalised recommendations