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Drug-Induced Dermatitis with Acetonides of Corticoids

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Current Topics in Contact Dermatitis

Summary

A 58-year-old female patient with recurrent ulcus cruris in connection with chronic venous insufficiency, as well as a known allergy to neomycin sulfate, benzocaine (Anesthesin), formalin, and (possibly) penicillin, developed severe eczema through treatment with triamcinolone acetonide (Volon A) shaking mix. Tests indicated an extensive eczematous cross-sensitivity to acetonide-substituted corticoids, such as triamcinolone acetonide, fluocinonide, fluocinolone acetonide, flurandrenolone, desonide, and halcinonide; in addition, allergies to adjuvants such as benzyl alcohol and sodium disulfite were diagnosed. Such cases of ulcus cruris often result in epidermal sensitization, which can also include topically applied corticoids. It is suspected that the lability of the acetonide group allows for the development of a common antigen determinant.

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Author information

Authors and Affiliations

  1. Universitäts-Hautklinik, Hauptstr. 7, D-7800, Freiburg im Breisgau, Germany

    O. M. Maucher, H. Knipper & M. Faber

Authors
  1. O. M. Maucher
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  2. H. Knipper
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  3. M. Faber
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Editor information

Editors and Affiliations

  1. Hautklinik der Universität Heidelberg, Voßstraße 2, 6900, Heidelberg 1, Germany

    Peter Frosch

  2. Department of Medical Research (Dermatology), Katholieke Universiteit Leuven, 3000, Leuven, Belgium

    A. Dooms-Goossens P.Ph., Ph.D.

  3. Unit and Laboratory of Occupational and Environmental Dermatology, Catholic University of Louvain, 30, Clos Chapelle-aux-Champs, UCL 3033, 1200, Brussels, Belgium

    J.-M. Lachapelle M. D. (Professor of Dermatology) (Professor of Dermatology)

  4. St. John’s Hospital for Diseases of the Skin, Lisle Street, London, WC2H 7BJ, Great Britain

    R. J. G. Rycroft

  5. Department of Pathology, Free University Hospital, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    R. J. Scheper

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© 1989 Springer-Verlag Berlin Heidelberg

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Maucher, O.M., Knipper, H., Faber, M. (1989). Drug-Induced Dermatitis with Acetonides of Corticoids. In: Frosch, P., Dooms-Goossens, A., Lachapelle, JM., Rycroft, R.J.G., Scheper, R.J. (eds) Current Topics in Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74299-6_48

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  • DOI: https://doi.org/10.1007/978-3-642-74299-6_48

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74301-6

  • Online ISBN: 978-3-642-74299-6

  • eBook Packages: Springer Book Archive

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