Drug-Induced Dermatitis with Acetonides of Corticoids

  • O. M. Maucher
  • H. Knipper
  • M. Faber


A 58-year-old female patient with recurrent ulcus cruris in connection with chronic venous insufficiency, as well as a known allergy to neomycin sulfate, benzocaine (Anesthesin), formalin, and (possibly) penicillin, developed severe eczema through treatment with triamcinolone acetonide (Volon A) shaking mix. Tests indicated an extensive eczematous cross-sensitivity to acetonide-substituted corticoids, such as triamcinolone acetonide, fluocinonide, fluocinolone acetonide, flurandrenolone, desonide, and halcinonide; in addition, allergies to adjuvants such as benzyl alcohol and sodium disulfite were diagnosed. Such cases of ulcus cruris often result in epidermal sensitization, which can also include topically applied corticoids. It is suspected that the lability of the acetonide group allows for the development of a common antigen determinant.

Key words

Acetonide-substituted corticoids Cross-sensitivity Allergic contact dermatitis Adjuvants 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • O. M. Maucher
    • 1
  • H. Knipper
    • 1
  • M. Faber
    • 1
  1. 1.Universitäts-HautklinikFreiburg im BreisgauGermany

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