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A Method for In Vitro Evaluation of Skin Protective Agents Against Epoxy Resin

  • N. Wiegersma
  • P. J. Coenraads
  • J. P. Nater
Conference paper

Summary

Sensitization and subsequent allergic contact dermatitis due to contact with epoxy resin constitutes a major problem in epoxy workers. In search of ways to protect the skin against exposure to epoxy resin an in vitro method was used to evaluate the efficiency of a series of possible barriers. This method is based upon the determination of the breakthrough time of low molecular weight epoxy resin through a standardized layer of cream or polymer derived from an aerosol spray. Detection of the penetrated epoxy resin in the recipient medium, i. e. a test paper, was carried out by means of the naked eye and interferometric infrared spectroscopy. The method has been applied to a series of creams and aerosol-derived polymer films. Significant differences in breakthrough times were observed, indicating that the method can be used for the comparison of the barrier function of potential protective agents.

Key words

Epoxy resin Interferometric infrared spectroscopy Skin protection 

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References

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    Demon CR, Birmingham DJ, Perone VB (1955) A laboratory evaluation of silicone skin-protective preparations. Arch Dermatol 70: 7–12.Google Scholar
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    Fregert S, Thorgeirrson A (1977) Patch testing with low molecular oligomers of epoxy resin in humans. Contact Dermatitis 3: 301–303.PubMedCrossRefGoogle Scholar
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    Prens EP, De Jong G, Van Joost T (1986) Sensitization to epichlorohydrin and epoxy system components. Contact Dermatitis 15: 85–90.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • N. Wiegersma
    • 1
  • P. J. Coenraads
    • 1
  • J. P. Nater
    • 1
  1. 1.Occupational Dermatology UnitUniversity Hospital GroningenThe Netherlands

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