A Method for In Vitro Evaluation of Skin Protective Agents Against Epoxy Resin
Sensitization and subsequent allergic contact dermatitis due to contact with epoxy resin constitutes a major problem in epoxy workers. In search of ways to protect the skin against exposure to epoxy resin an in vitro method was used to evaluate the efficiency of a series of possible barriers. This method is based upon the determination of the breakthrough time of low molecular weight epoxy resin through a standardized layer of cream or polymer derived from an aerosol spray. Detection of the penetrated epoxy resin in the recipient medium, i. e. a test paper, was carried out by means of the naked eye and interferometric infrared spectroscopy. The method has been applied to a series of creams and aerosol-derived polymer films. Significant differences in breakthrough times were observed, indicating that the method can be used for the comparison of the barrier function of potential protective agents.
Key wordsEpoxy resin Interferometric infrared spectroscopy Skin protection
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