Nickel Bioavailability from Patch Tests: Comparison Between Nickel Sulphate and Nickel Chloride Using TRUE Test
The development of local allergic skin reactions in nickel-sensitive individuals was examined with the TRUE Test, using various application times and different test concentrations of nickel sulphate and nickel chloride. The positive reactions seen with standard nickel sulphate concentration in the TRUE Test were comparable with those seen with the Finn chamber method. For both tests 48-h occlusion was needed for the optimal result. Three times higher nickel sulphate concentrations did not improve the results. Nickel chloride in the new vehicle of the TRUE Test penetrated the skin more effectively to trigger the immune system, since positive results comparable to the above-mentioned nickel sulphate tests were seen already after 3–6 h patch application when the actual nickel concentrations were comparable.
Key wordsTRUE Test Finn chamber test Nickel sulphate Nickel chloride
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