Abstract
New methods in the treatment of brain tumors, e.g., boron neutron capture therapy, external stereotactic irradiation by linear accelerator, and the use of chemotherapy and interferons in patients with malignant brain tumors, demand not only knowledge of the localization and histology of the lesion. Information on the pathophysiological behavior of the tumor and edematous tissue is also important for planning strategies involving these therapeutic methods. An important factor for the irradiation sensitivity of brain tumors is the oxygénation of the tissue [2,8]. Failure of radiotherapy can be explained by various factors, e.g., the presence of hypoxic or anoxic cells in the tumor area [1]. The effectiveness of chemotherapy depends on drug concentration in the tumor tissue. Both examples illustrate the importance of studies dealing with measurements of tumor perfusion.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Chapman JD (1984) The detection and measurement of hypoxic cells, in solid tumors. Cancer 54: 2441–2449
Colombo F, Benedetti A, Pozza F, Avanco R, Marchetti C, Chierego G, Zanardo H (1985) External stereotactic irradiation by linear accelerator. Neurosurgery 16: 154–160
Cordes M, Rummeny E, Reissmann M, Fox K, Panitz N, Pfannenstiel P (1987) HM-PAO SPECT in der Diagnostik der cerebro-vaskulären Erkrankung.Der Nuklearmediziner 10: 93–97
Creutzig H, Schober O, Gielow P, Friedrich P, Becker H, Dietz H, Hundeshagen H (1986) Cerebral dynamics of N-isopropyl-(123-1) p-iodoamphetamine. J Nucl Med 27: 178–183
Drayer B, Jaszak R, Friedman A, Albright R, Rung H, Geer K, Lischko M, Petry N, Coleman E (1983) In vivo quantitation of regional cerebral blood flow in glioma and cerebral infarction: validation of the HIPDM-SPECT method. AJNR 4: 572–576
Holman BL, Lee RGL, Hill TC, Lovett RD, Lister-James J (1984) A comparison of two cerebral perfusion tracers, N-isopropyl-I-123 p-iodoamphetamine and 1-123 HIPDM, in the human. J Nucl Med 25: 25–30
Langen KJ, Roosen N, Kuwert T, Herzog H, Kiwit JCW, Bock WJ, Feinendegen LE (1987) 99m Tc-HMPAO SPECT in the study of cerebral tumors: results in 40 patients. Nuklearmedizin 26: 118
Sheline GE (1986) Normal tissue tolerance and radiation therapy of gliomas of the-adult brain. In: Bleehan NM (ed) Tumors of the brain. Springer-Verlag Berlin, pp 147–161
Tyler JL, Dikcic M, Villemure JG, Evans AC, Meyer E, Yamamoto JL, Feindel W (1987) Metabolic and hemodynamic evaluation of gliomas using positron emmission tomography. J Nucl Med 28: 1123–1133
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Maier-Hauff, K., Gerlach, L., Baerwald, R., Cordes, M. (1989). Cerebral Blood Flow Measurements with 99mTc-HMPAO and123 I — Amphetamine (HIPDM) in Patients with Cerebral Tumors (1). In: Frowein, R.A., Brock, M., Klinger, M. (eds) Head Injuries. Advances in Neurosurgery, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74279-8_61
Download citation
DOI: https://doi.org/10.1007/978-3-642-74279-8_61
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-50550-1
Online ISBN: 978-3-642-74279-8
eBook Packages: Springer Book Archive