Cell Biology of Insulin Action on Glucose Transport and Its Perturbation in Diabetes Mellitus

  • B. B. Kahn
  • S. W. Cushman
Conference paper
Part of the Bayer AG Centenary Symposium book series (BAYER)

Abstract

Glucose entry into cells is key for mammalian survival. Impairment of glucose entry results in a catabolic state marked by hyperglycemia, dehydration and starvation known as diabetes mellitus. The clinical observation that insulin could lower blood glucose levels and reverse the catabolic state of diabetes mellitus was made by Banting, Best, and colleagues [1–3] as early as 1922. More than 25 years passed before insights into the cellular mechanisms for this dramatically therapeutic effect of insulin emerged. In the 1950s Levine and colleagues [4–6] proposed that insulin might stimulate the transport of glucose across the plasma membrane of target cells. Not until 1965 did Crofford and Renold [7, 8] provide direct evidence for this fundamental action of insulin. In this review recent progress in understanding the mechanisms by which insulin stimulates glucose entry into muscle and adipose cells will be described. Additionally, the direct application of these mechanisms to the pathophysiology of diabetes mellitus and its reversal with insulin therapy will be discussed.

Keywords

Obesity Vanadate Dehydration Cyanide Catecholamine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • B. B. Kahn
  • S. W. Cushman

There are no affiliations available

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