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Diabetes Mellitus: Pathophysiology and Therapy pp 63–70Cite as

Islet Amyloid and Type 2 Diabetes

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Part of the book series: Bayer AG Centenary Symposium ((BAYER))

Abstract

The pathologic alterations of the pancreas in type 2 diabetes are more discrete than in type 1 diabetes. It has therefore been claimed, even quite recently, that the morphology of the islets is normal in this maturity form of the disease. However, there are some changes which are typical of type 2 diabetes and demonstrable in most, although not all cases. The most constant of these changes is probably deposition of amyloid in the islets of Langerhans.

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References

  1. Opie EL (1900) On relation of chronic interstitial pancreatitis to the islets of Langerhans and to diabetes mellitus. J Exp Med 5: 397–428

    Article  Google Scholar 

  2. Weichselbaum A, Stangl E (1901) Zur Kenntnis der feineren Veranderungen des Pankreas bei Diabetes mellitus. Wien Klin Wochenschr 14: 968–972

    Google Scholar 

  3. Gellerstedt N (1938) Die elektive, insulare (Para-) Amyloidose der Bauchspeicheldriise. Beitr Path Anat 101: 1–13

    Google Scholar 

  4. Ahronheim JH (1943) The nature of the hyaline material in the pancreatic islands in diabetes mellitus. Am J Path 19: 873–882

    PubMed  CAS  Google Scholar 

  5. Arey JB (1943) Nature of the hyaline changes in islands of Langerhans in diabetes mellitus. Arch Pathol 36: 32–38

    CAS  Google Scholar 

  6. Ehrlich JC, Ratner IM (1961) Amyloidosis of the islets of Langerhans. A restudy of islet hyalin in diabetic and nondiabetic individuals. Am J Pathol 38: 49–59

    Google Scholar 

  7. Glenner GG (1980) Amyloid deposits and amyloidosis. The β-fibrilloses. N Engl J Med 302: 1283–1292 and 1333–1343

    Google Scholar 

  8. Glenner GG, Eanes ED, Bladen HA, Linke RP, Termine JD (1974) Beta-pleated sheet fibrils. A comparison of native amyloid with synthetic protein fibrils. J Histochem Cytochem 22: 1141–1158

    Google Scholar 

  9. Westermark P, Johnson KH (1988) The polypeptide hormone-derived amyloid forms: non-specific alterations or signs of abnormal peptide-processing? APMIS 96: 475–483

    Article  PubMed  CAS  Google Scholar 

  10. Westermark P, Grimelius L (1973) The pancreatic islet cells in insular amyloidosis in human diabetic and non-diabetic adults. Acta Path Microbiol Scand A 81: 291–300

    CAS  Google Scholar 

  11. Westermark P (1977) Amyloid of human islets of Langerhans. II. Electron microscopic analysis of isolated amyloid. Virchows Arch Path Anat 373: 161–166

    CAS  Google Scholar 

  12. Westermark P (1973) Fine structure of islets of Langerhans in insular amyloidosis. Virchows Arch Path Anat 359: 1–18

    CAS  Google Scholar 

  13. Westermark P (1972) Quantitative studies of amyloid in the islets of Langerhans. Upsala J Med Sci 77: 91–94

    PubMed  CAS  Google Scholar 

  14. Clark A, Holman RR, Matthews DR, Hockaday TDR, Turner RC (1984) Non-uniform distribution of amyloid in the pancreas of “maturity-onset” diabetic patients. Diabetologia 27: 527–528

    Article  PubMed  CAS  Google Scholar 

  15. Lazarus SS, Volk BW (1962) The pancreas in human and experimental diabetes. Grune and Stratton, New York

    Google Scholar 

  16. Bell ET (1959) Hyalinization of the islets of Langerhans in nondiabetic individuals. Am J Pathol 35: 801–805

    PubMed  CAS  Google Scholar 

  17. Ludwig G, Heitner H (1967) Zur Häufigkeit der Inselamyloidose des Pankreas beim Diabetes mellitus. Zschr Inn Med 22: 814–818

    CAS  Google Scholar 

  18. Westermark P, Wilander E (1978) The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus. Diabetologia 15: 417–421

    Article  PubMed  CAS  Google Scholar 

  19. Westermark P, Cornwell GG III (1986) Varied composition and nature of senile localized amyloid: implications for varied mechanisms of pathogenesis. In: Glenner GG, Osserman EF, Benditt EP, Calkins E, Cohen AS, Zucker-Franklin D (eds) Amyloidosis. Plenum Press, New York, pp 659–668

    Chapter  Google Scholar 

  20. Westermark P, Grimelius L, Polak JM, Larsson L-I, van Noorden S, Wilander E, Pearse AGE (1977) Amyloid in polypeptide hormone-producing tumors. Lab Invest 37: 212–215

    PubMed  CAS  Google Scholar 

  21. Berns AW, Owens CT, Blumenthal HT (1964) A histo-and immunopathologie study of the vessels and islets of Langerhans of the pancreas in diabetes mellitus. J Gerontol 19: 179–189

    PubMed  CAS  Google Scholar 

  22. Lacy PE (1964) Pancreatic beta cell. In: Aetiology of diabetes and its complications. Ciba Foundation Colloquia on Endocrinology. Little, Brown, Boston, p 75

    Google Scholar 

  23. Westermark P (1974) On the nature of the amyloid in human islets of Langerhans. Histochemistry 38: 27–33

    Article  CAS  Google Scholar 

  24. Westermark P, Wilander E (1983) Islet amyloid in type 2 (non-insulin-dependent) diabetes is related to insulin. Diabetologia 24: 342–346

    Article  PubMed  CAS  Google Scholar 

  25. Westermark P (1975) Amyloid of medullary carcinoma of the thyroid: partial characterization. Upsala J Med Sci 80: 88–92

    Article  PubMed  CAS  Google Scholar 

  26. Westermark P, Wernstedt C, Wilander E, Sletten K (1986) A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas. Biochem Biophys Res Commun 140: 827–831

    Article  PubMed  CAS  Google Scholar 

  27. Westermark P, Wernstedt C, Wilander E, Hayden DW, O’Brien TD, Johnson KH (1987) Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a novel neuropeptide-like protein also present in normal islet cells. Proc Natl Acad Sci USA 84: 3881–3885

    Article  PubMed  CAS  Google Scholar 

  28. Westermark P, Wernstedt C, O’Brien TD, Hayden DW, Johnson KH (1987) Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone. Am J Pathol 127: 414–417

    PubMed  CAS  Google Scholar 

  29. Cooper GJS, Willis AC, Clark A, Turner RC, Sim RB, Reid KBM (1987) Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 84: 8628–8632

    Article  PubMed  CAS  Google Scholar 

  30. Dische FE, Wernstedt C, Westermark GT, Westermark P, Pepys MB, Rennie JA, Gilbey SG, Watkins PJ (1988) Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient. Diabetologia 31: 158–161

    Article  PubMed  CAS  Google Scholar 

  31. Johnson KH, Stevens JB (1973) Light and electron microscopic studies of islet amyloid in diabetic cats. Diabetes 22: 81–90

    PubMed  CAS  Google Scholar 

  32. Johnson KH, Hayden DW, O’Brien TD, Westermark P (1986) Spontaneous diabetes mellitus-islet amyloid complex in adult cats. Am J Pathol 125: 416–419

    PubMed  CAS  Google Scholar 

  33. Howard CF (1978) Insular amyloidosis and diabetes mellitus in Macaca nigra. Diabetes 27: 357–364

    Article  PubMed  CAS  Google Scholar 

  34. Westermark P, Wilander E, Westermark GT, Johnson KH (1987) Islet amyloid polypeptide-like immunoreactivity in the islet B cells of type 2 (non-insulin-dependent) diabetic and non-diabetic individuals. Diabetologia 30: 887–892

    PubMed  CAS  Google Scholar 

  35. Johnson KH, O’Brien TD, Hayden DW, Jordan K, Ghobrial HKG, Mahoney WC, Westermark P (1988) Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells by means of peroxidase antiperoxidase ( PAP) and protein A-gold techniques. Am J Pathol 130: 1–8

    Google Scholar 

  36. Westermark P, Engsträm U, Westermark GT, Wilander E, Johnson KH (1988) A limited segment of islet amyloid polypeptide (IAPP) is related to amyloid fibril formation in type 2 diabetes. (Submitted for publication)

    Google Scholar 

  37. Westermark P, Johnson KH (1988) The pathogenesis of maturity onset diabetes mellitus: Is there a link to islet amyloid polypeptide? Bio Essays 9: 30–33

    CAS  Google Scholar 

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Authors
  1. P. Westermark
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Editors and Affiliations

  1. Medizinische Klinik und Poliklinik Abteilung für Gastroenterologie und Endokrinologie, Georg-August-Universität Göttingen, Robert-Koch-Straße 40, 3400, Göttingen, Germany

    Werner Creutzfeldt

  2. Diabetes, Nutrition and Metabolic Disorders Unit, CHU Sart Tilman (B 35), 4000, Liège, Belgium

    Pierre J. Lefèbvre

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© 1989 Springer-Verlag Berlin Heidelberg

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Westermark, P. (1989). Islet Amyloid and Type 2 Diabetes. In: Creutzfeldt, W., Lefèbvre, P.J. (eds) Diabetes Mellitus: Pathophysiology and Therapy. Bayer AG Centenary Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74255-2_5

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  • DOI: https://doi.org/10.1007/978-3-642-74255-2_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50506-8

  • Online ISBN: 978-3-642-74255-2

  • eBook Packages: Springer Book Archive

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