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Abnormal Glucagon Secretion in Type 2 (Noninsulin-Dependent) Diabetes Mellitus: Causes and Consequences

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Diabetes Mellitus: Pathophysiology and Therapy

Part of the book series: Bayer AG Centenary Symposium ((BAYER))

Abstract

Insulin and glucagon are generally acknowledged to be the most important hormones responsible for the moment-to-moment control of plasma glucose concentrations in man [41]. This is due to their immediate antagonistic effects on the liver; insulin suppresses hepatic glucose output and glucagon stimulates hepatic glucose output. Moreover, secretion of these hormones is reciprocally regulated by glucose; an increase in arterial glucose stimulates insulin secretion and suppresses glucagon secretion, whereas a decrease in arterial glucose suppresses insulin secretion and stimulates glucagon secretion [15].

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Authors
  1. J. E. Gerich
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Editors and Affiliations

  1. Medizinische Klinik und Poliklinik Abteilung für Gastroenterologie und Endokrinologie, Georg-August-Universität Göttingen, Robert-Koch-Straße 40, 3400, Göttingen, Germany

    Werner Creutzfeldt

  2. Diabetes, Nutrition and Metabolic Disorders Unit, CHU Sart Tilman (B 35), 4000, Liège, Belgium

    Pierre J. Lefèbvre

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© 1989 Springer-Verlag Berlin Heidelberg

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Gerich, J.E. (1989). Abnormal Glucagon Secretion in Type 2 (Noninsulin-Dependent) Diabetes Mellitus: Causes and Consequences. In: Creutzfeldt, W., Lefèbvre, P.J. (eds) Diabetes Mellitus: Pathophysiology and Therapy. Bayer AG Centenary Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74255-2_10

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  • DOI: https://doi.org/10.1007/978-3-642-74255-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50506-8

  • Online ISBN: 978-3-642-74255-2

  • eBook Packages: Springer Book Archive

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