Abnormal Glucagon Secretion in Type 2 (Noninsulin-Dependent) Diabetes Mellitus: Causes and Consequences

  • J. E. Gerich
Part of the Bayer AG Centenary Symposium book series (BAYER)


Insulin and glucagon are generally acknowledged to be the most important hormones responsible for the moment-to-moment control of plasma glucose concentrations in man [41]. This is due to their immediate antagonistic effects on the liver; insulin suppresses hepatic glucose output and glucagon stimulates hepatic glucose output. Moreover, secretion of these hormones is reciprocally regulated by glucose; an increase in arterial glucose stimulates insulin secretion and suppresses glucagon secretion, whereas a decrease in arterial glucose suppresses insulin secretion and stimulates glucagon secretion [15].


Glucagon Secretion Postprandial Hyperglycemia Plasma Glucagon Nondiabetic Subject Hepatic Glucose Output 
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© Springer-Verlag Berlin Heidelberg 1989

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  • J. E. Gerich

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