A Historical Review of the Genesis and Early Development of Intrusive Pulse-Echo Ultrasound
The development of semi-invasive instrumentation arose as a logical step to overcome frequency-range resolution and other basic acoustic limitations. These limitations, emerging as the work progressed in laboratory and clinic, followed two primary basic scientific discoveries reported in 1949. These discoveries were (a) sonic energy reflection from both gross and fine histological structure of soft tissues  and (b) observation of differential sonic reflection and acoustic properties of cancerous tissue . Follow-up of these fundamental observations founded the field of diagnostic ultrasound and set the stage for early cancer detection at accessible sites on a screening basis [8–10].
KeywordsHistorical Review Stomach Wall Cervix Uterus Gain Setting Early Cancer Detection
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