Identification and Function of Bile Salt Binding Polypeptides of Hepatocyte Membrane
In the course of their enterohepatic circulation bile salts are taken up through the sinusoidal and secreted through the canalicular membrane of the hepatocyte. In these different membrane domains different bile-salt- binding polypeptides are present, as demonstrated unequivocally by photo-affinity-labelling studies (Kramer et al., 1982; Buscher et al., 1987; Fricker et al., 1987). All these binding polypeptides could somehow be involved in hepatobiliary bile salt transport.
KeywordsAlbumin Polypeptide Photolysis Carbene Cholan
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