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Identification and Function of Bile Salt Binding Polypeptides of Hepatocyte Membrane

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Hepatic Transport of Organic Substances

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

In the course of their enterohepatic circulation bile salts are taken up through the sinusoidal and secreted through the canalicular membrane of the hepatocyte. In these different membrane domains different bile-salt- binding polypeptides are present, as demonstrated unequivocally by photo-affinity-labelling studies (Kramer et al., 1982; Buscher et al., 1987; Fricker et al., 1987). All these binding polypeptides could somehow be involved in hepatobiliary bile salt transport.

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References

  • Buscher HP, Fricker G, Gerok W, Kramer W, Kurz G, Müller M and Schneider S (1986) Membrane transport of amphiphilic compounds by hepatocytes. in: Receptor-Mediated Uptake in the Liver ( Greten H, Windler G and Beisiegel U, eds.), Springer-Verlag, Berlin, Heidelberg, 189–199

    Google Scholar 

  • Buscher HP, Fricker G, Gerok W, Kurz G, Müller M and Schneider S, Schramm U and Schreyer A (1987) Hepatic transport systems for bile salts: localization and specificity, in: Bile Acids and the Liver with an Update on Gallstone Disease ( Paumgartner G, Stiehl A and Gerok W, eds.) MTP Press Ltd., Lancaster, UK, 95–110

    Google Scholar 

  • Fricker G, Schneider S, Gerok W and Kurz G (1987) Identification of different transport systems for bile salts in sinusoidal and canalicular membranes of hepatocytes. Biol Chem Hoppe-Seyler 368: 1143–1150

    Article  PubMed  CAS  Google Scholar 

  • Frimmer M and Ziegler K (1986) Photoaffinity labeling of whole cells by flashed light: a simple apparatus for high-energy ultraviolet flashes. Biochim Biophys Acta 855: 143–146

    Article  PubMed  CAS  Google Scholar 

  • Kramer W, Bickel U, Buscher H-P, Gerok W and Kurz G (1982) Bile-salt- binding polypeptides in plasma membranes of hepatocytes revealed by photoaffinity labelling. Eur J Biochem 129: 13–24

    Article  PubMed  CAS  Google Scholar 

  • Kramer W and Kurz G (1983) Photolabile derivatives of bile salts. Synthesis and suitability for photoaffinity labeling. J Lipid Res 24: 910–923

    PubMed  CAS  Google Scholar 

  • Kröncke KD, Fricker G, Meier PJ, Gerok W, Wieland T and Kurz G (1986) α− Amanitin uptake into hepatocytes. Identification of hepatic membrane transport systems used by amatoxins. J Biol Chem 261: 12562–12567

    PubMed  Google Scholar 

  • Torres MJ, Zayas J and Platz MS (1986) A formal CH insertion reaction of an aryl nitrene into an alkyl CH bond. Implications for photoaffinity labelling. Tetrahedron Lett 27: 791–794

    Article  CAS  Google Scholar 

  • Wieland T, Nassal M, Kramer W, Fricker G, Bickel U and Kurz G (1984) Identity of hepatic membrane transport systems for bile salts, phalloidin, and antamanide by photoaffinity labeling. Proc Natl Acad Sci USA 81: 5232–5236

    Article  PubMed  CAS  Google Scholar 

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© 1989 Springer-Verlag Berlin Heidelberg

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Kurz, G., Müller, M., Schramm, U., Gerok, W. (1989). Identification and Function of Bile Salt Binding Polypeptides of Hepatocyte Membrane. In: Petzinger, E., Kinne, R.K.H., Sies, H. (eds) Hepatic Transport of Organic Substances. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74247-7_27

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  • DOI: https://doi.org/10.1007/978-3-642-74247-7_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74249-1

  • Online ISBN: 978-3-642-74247-7

  • eBook Packages: Springer Book Archive

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