Hepatobiliary Cysteinyl Leukotriene Elimination

  • M. Huber
  • T. Baumert
  • A. Guhlmann
  • D. Mayer
  • D. Keppler
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


The cysteinyl leukotrienes, LTC4, LTD4, LTE4, and N-acetyl-LTE4, are highly potent lipid mediators which are derived from arachidonate (Lewis and Austen, 1984; Hammarström et al., 1985; Piper and Samhoun, 1987; Samuelsson et al., 1987). 5-Lipoxygenase/LTA4 synthase (Dixon et al., 1988; Matsumoto et al., 1988) converts arachidonate to the epoxide LTA4 which is subsequently conjugated with glutathione by a particulate LTC4 synthase (Söderström et al., 1988; Yoshimoto et al., 1988). LTC4 is metabolized to LTD4, LTE4, and N-acetyl-LTE4 (Fig. 1). Predominant cellular sources of LTC4 are eosinophils, mast cells, macrophages, and monocytes (Weller et al., 1983; Lewis and Austen, 1984; Williams et al., 1984). The cysteinyl leukotrienes are potent smooth muscle constrictors involved in inflammatory and anaphylactic reactions, in the release of luteinizing hormone, and in cell proliferation (Lewis and Austen, 1984; Baud et al., 1985; Hammarstrom et al., 1985; Kragballe et al., 1985; Piper and Samhoun, 1987; Samuelsson et al., 1987). Their effects are mediated through well-defined receptors on the cell surface (Mong et al., 1988; Winkler et al., 1988). In human isolated bronchi and lung parenchyma LTE4 is less potent than either LTC4 or LTD4 (Piper and Samhoun, 1987). Although 25-fold less active than LTD4 in the guinea-pig pulmonary parenchymal strip (Lewis et al., 1981), N-acetyl-LTE4 is still a potent constrictor of rat mesenteric vessels (Siren et al., 1988).


Hepatorenal Syndrome Hepatobiliary Elimination Epithelial Liver Cell Line Hepatocellular Uptake Human Glomerular Epithelial Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • M. Huber
    • 1
  • T. Baumert
    • 1
  • A. Guhlmann
    • 1
  • D. Mayer
    • 2
  • D. Keppler
    • 1
  1. 1.Division of Tumor BiochemistryDeutsches KrebsforschungszentrumHeidelberg 1Federal Republic of Germany
  2. 2.Division of CytopathologyDeutsches KrebsforschungszentrumHeidelberg 1Federal Republic of Germany

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