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The Role of Macrophages in the Regulation of Tumor Growth and Metastasis

  • B. Bottazzi
  • R. Giavazzi
  • N. Nobili
  • F. Fazioli
  • A. Mantovani
Conference paper

Abstract

Macrophages are a major component of the lymphoreticular infiltrate of rodent and human tumors (Key 1983; Mantovani et al. 1987). Since these cells are situated at the very interface between tumor and host, they may represent a strategically located target for therapeutic intervention. Interest in these cells is stimulated by the knowledge that macrophages have the potential to kill neo-plastic cells, including drug-resistant variants surviving conventional chemotherapy (Giavazzi et al. 1984; Allavena et al. 1987).

Keywords

Mononuclear Phagocyte Phorbol Myristate Acetate Tumor Cell Adhesion Macro Phage Peritoneal Exudate Macrophage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • B. Bottazzi
    • 1
  • R. Giavazzi
    • 2
  • N. Nobili
    • 1
  • F. Fazioli
    • 1
  • A. Mantovani
    • 1
  1. 1.Istituto di Ricerche Farmacologiche Mario NegriMilanItaly
  2. 2.BergamoItaly

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