Skip to main content

The Role of Macrophages in the Regulation of Tumor Growth and Metastasis

  • Conference paper
Cancer Metastasis
  • 90 Accesses

Abstract

Macrophages are a major component of the lymphoreticular infiltrate of rodent and human tumors (Key 1983; Mantovani et al. 1987). Since these cells are situated at the very interface between tumor and host, they may represent a strategically located target for therapeutic intervention. Interest in these cells is stimulated by the knowledge that macrophages have the potential to kill neo-plastic cells, including drug-resistant variants surviving conventional chemotherapy (Giavazzi et al. 1984; Allavena et al. 1987).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allavena P, Grandi M, d’Incalci M, Geri O, Giuliani FC, Mantovani A (1987) Human tumor cell lines with pleiotropic drug resistance are efficiently killed by interleukin-2 activated killer cells and by activated monocytes. Int J Cancer 40:104–107

    Article  PubMed  CAS  Google Scholar 

  • Bottazzi B, Polentarutti N, Acero R, Balsari A, Boraschi D, Ghezzi P, Salmona M, Mantovani A (1983) Regulation of the macrophage content of neoplasms by chemoattractants. Science 220:210–212

    Article  PubMed  CAS  Google Scholar 

  • Collart MA, Belin D, Vassalli J-D, Vassalli P (1987) Modulations of functional activity in differentiated macrophages are accompanied by early and transient increase or decrease in c-fos gene transcription. J Immunol 139:949–955

    PubMed  CAS  Google Scholar 

  • Colotta F, Lampugnani MS, Polentarutti N, Dejana E, Mantovani A (1988a) Interleukin-1 induces c-fos protooncogene expression in cultured human endothelial cells. Biochem Biophys Res Commun 152:1104–1110

    Article  PubMed  CAS  Google Scholar 

  • Colotta F, Polentarutti N, Pirelli A, Dibello M, Allavena P, Mantovani A (1988b) c-fos Protooncogene expression in human NK/LGL cells: Expression is not constitutive and is associated with functional activation. Int J Caner, (in press)

    Google Scholar 

  • Dejana E, Bertocchi F, Bortolami MC, Regonesi A, Tonta A, Breviario F, Giavazzi R (1988) Interleukin-1 promotes tumor cell adhesion to cultured human endothelial cells. J Clin Invest, (in press)

    Google Scholar 

  • Evans R, Cullen RT (1984) In situ proliferation of intratumor macrophages. J Leukocyte Biol 35:561–572

    PubMed  CAS  Google Scholar 

  • Giavazzi R, Bucana CD, Hart IR (1984) Correlation of tumor growth inhibitory activity of macrophages exposed to adriamycin and adriamycin sensitivity of the target tumor cells. JNCI 73:447–455

    PubMed  CAS  Google Scholar 

  • Gonda TJ, Metcalf D (1984) Expression of myb, myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia. Nature 310:249–251

    Article  PubMed  CAS  Google Scholar 

  • Ho Y-S, Lee WMF, Snyderman R (1987) Chemoattractant-induced activation of c-fos gene expression in human monocytes. J Exp Med 165:1524–1538

    Article  PubMed  CAS  Google Scholar 

  • Introna M, Hamilton TA, Kaufman RE, Adams DO, Bast RC Jr (1986) Treatment of murine peritoneal macrophages with bacterial lipopolysaccharide alters expression of c-fos and c-myc oncogenes. J Immunol 137:2711–2715

    PubMed  CAS  Google Scholar 

  • Introna M, Bast RC Jr, Johnston PA, Adams DO, Hamilton TA (1987) Homologous and heterologous desensitization of proto-oncogene c-fos expression in murine peritoneal macrophages. J Cell Physiol 131:36–42

    Article  PubMed  CAS  Google Scholar 

  • Mahoney KH, Heppner GH (1987) FACS analysis of tumor-associated macrophage replication: Differences between metastatic and nonmetastatic murine mammary tumors. J Leukocyte Biol 41:205–211

    PubMed  CAS  Google Scholar 

  • Mantovani A (1978) Effects on in vitro tumor growth of murine macrophages isolated from sarcoma lines differing in immunogenicity and metastasizing capacity. Int J Cancer 22:741–746

    Article  PubMed  CAS  Google Scholar 

  • Mantovani A (1981) In vitro effects on tumor cells of macrophages isolated from an early-passage chemically-induced murine sarcoma and from its spontaneous metastases. Int J Cancer 27:221–228

    Article  PubMed  CAS  Google Scholar 

  • Mantovani A, Bottazzi B, Allavena P, Balotta C (1987) Tumor-associated leukocytes in metastasizing tumors. In: Herberman RB, Wiltrout RH, Gorelik E (eds) Immune responses to metastases, vol I. CRC, Boca Raton, pp 106–118

    Google Scholar 

  • Mitchell RL, Zokas L, Schreiber RD, Verma IM (1985) Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation. Cell 40:209–217

    Article  PubMed  CAS  Google Scholar 

  • Muller R, Curran T, Muller D, Guilbert L (1985) Induction of c-fos during myelomonocytic differentiation and macrophage proliferation. Nature 314:546–548

    Article  PubMed  CAS  Google Scholar 

  • Radzioch D, Bottazzi B, Varesio L (1987) Augmentation of c-fos mRNA expression by activators of protein kinase C in fresh, terminally differentiated resting macrophages. Mol Cell Biol 7:595–599

    PubMed  CAS  Google Scholar 

  • Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley R (1985) The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell 41:665–676

    Article  PubMed  CAS  Google Scholar 

  • Stewart CC (1983) Local proliferation of mononuclear phagocytes in tumors. RES Reticu-loendothel Soc 34:23–27

    CAS  Google Scholar 

  • Stewart CC, Beetham KL (1978) Cytocidal activity and proliferative ability of macrophages infiltrating the EMT6 tumor. Int J Cancer 22:152–159

    Article  PubMed  CAS  Google Scholar 

  • Wang J-M, Cianciolo GJ, Snyderman R, Mantovani A (1986) Coexistence of a chemotactic factor and a retroviral P15E-related chemotaxis inhibitor in human tumor cell culture supernatants. J Immunol 137:2726–2732

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Bottazzi, B., Giavazzi, R., Nobili, N., Fazioli, F., Mantovani, A. (1989). The Role of Macrophages in the Regulation of Tumor Growth and Metastasis. In: Schirrmacher, V., Schwartz-Albiez, R. (eds) Cancer Metastasis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74236-1_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-74236-1_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50471-9

  • Online ISBN: 978-3-642-74236-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics