The Role of Macrophages in the Regulation of Tumor Growth and Metastasis

  • B. Bottazzi
  • R. Giavazzi
  • N. Nobili
  • F. Fazioli
  • A. Mantovani
Conference paper


Macrophages are a major component of the lymphoreticular infiltrate of rodent and human tumors (Key 1983; Mantovani et al. 1987). Since these cells are situated at the very interface between tumor and host, they may represent a strategically located target for therapeutic intervention. Interest in these cells is stimulated by the knowledge that macrophages have the potential to kill neo-plastic cells, including drug-resistant variants surviving conventional chemotherapy (Giavazzi et al. 1984; Allavena et al. 1987).


Mononuclear Phagocyte Phorbol Myristate Acetate Tumor Cell Adhesion Macro Phage Peritoneal Exudate Macrophage 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • B. Bottazzi
    • 1
  • R. Giavazzi
    • 2
  • N. Nobili
    • 1
  • F. Fazioli
    • 1
  • A. Mantovani
    • 1
  1. 1.Istituto di Ricerche Farmacologiche Mario NegriMilanItaly
  2. 2.BergamoItaly

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