The Role of Macrophages in the Regulation of Tumor Growth and Metastasis
Macrophages are a major component of the lymphoreticular infiltrate of rodent and human tumors (Key 1983; Mantovani et al. 1987). Since these cells are situated at the very interface between tumor and host, they may represent a strategically located target for therapeutic intervention. Interest in these cells is stimulated by the knowledge that macrophages have the potential to kill neo-plastic cells, including drug-resistant variants surviving conventional chemotherapy (Giavazzi et al. 1984; Allavena et al. 1987).
KeywordsMononuclear Phagocyte Phorbol Myristate Acetate Tumor Cell Adhesion Macro Phage Peritoneal Exudate Macrophage
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