Abstract
Macrophages are a major component of the lymphoreticular infiltrate of rodent and human tumors (Key 1983; Mantovani et al. 1987). Since these cells are situated at the very interface between tumor and host, they may represent a strategically located target for therapeutic intervention. Interest in these cells is stimulated by the knowledge that macrophages have the potential to kill neo-plastic cells, including drug-resistant variants surviving conventional chemotherapy (Giavazzi et al. 1984; Allavena et al. 1987).
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References
Allavena P, Grandi M, d’Incalci M, Geri O, Giuliani FC, Mantovani A (1987) Human tumor cell lines with pleiotropic drug resistance are efficiently killed by interleukin-2 activated killer cells and by activated monocytes. Int J Cancer 40:104–107
Bottazzi B, Polentarutti N, Acero R, Balsari A, Boraschi D, Ghezzi P, Salmona M, Mantovani A (1983) Regulation of the macrophage content of neoplasms by chemoattractants. Science 220:210–212
Collart MA, Belin D, Vassalli J-D, Vassalli P (1987) Modulations of functional activity in differentiated macrophages are accompanied by early and transient increase or decrease in c-fos gene transcription. J Immunol 139:949–955
Colotta F, Lampugnani MS, Polentarutti N, Dejana E, Mantovani A (1988a) Interleukin-1 induces c-fos protooncogene expression in cultured human endothelial cells. Biochem Biophys Res Commun 152:1104–1110
Colotta F, Polentarutti N, Pirelli A, Dibello M, Allavena P, Mantovani A (1988b) c-fos Protooncogene expression in human NK/LGL cells: Expression is not constitutive and is associated with functional activation. Int J Caner, (in press)
Dejana E, Bertocchi F, Bortolami MC, Regonesi A, Tonta A, Breviario F, Giavazzi R (1988) Interleukin-1 promotes tumor cell adhesion to cultured human endothelial cells. J Clin Invest, (in press)
Evans R, Cullen RT (1984) In situ proliferation of intratumor macrophages. J Leukocyte Biol 35:561–572
Giavazzi R, Bucana CD, Hart IR (1984) Correlation of tumor growth inhibitory activity of macrophages exposed to adriamycin and adriamycin sensitivity of the target tumor cells. JNCI 73:447–455
Gonda TJ, Metcalf D (1984) Expression of myb, myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia. Nature 310:249–251
Ho Y-S, Lee WMF, Snyderman R (1987) Chemoattractant-induced activation of c-fos gene expression in human monocytes. J Exp Med 165:1524–1538
Introna M, Hamilton TA, Kaufman RE, Adams DO, Bast RC Jr (1986) Treatment of murine peritoneal macrophages with bacterial lipopolysaccharide alters expression of c-fos and c-myc oncogenes. J Immunol 137:2711–2715
Introna M, Bast RC Jr, Johnston PA, Adams DO, Hamilton TA (1987) Homologous and heterologous desensitization of proto-oncogene c-fos expression in murine peritoneal macrophages. J Cell Physiol 131:36–42
Mahoney KH, Heppner GH (1987) FACS analysis of tumor-associated macrophage replication: Differences between metastatic and nonmetastatic murine mammary tumors. J Leukocyte Biol 41:205–211
Mantovani A (1978) Effects on in vitro tumor growth of murine macrophages isolated from sarcoma lines differing in immunogenicity and metastasizing capacity. Int J Cancer 22:741–746
Mantovani A (1981) In vitro effects on tumor cells of macrophages isolated from an early-passage chemically-induced murine sarcoma and from its spontaneous metastases. Int J Cancer 27:221–228
Mantovani A, Bottazzi B, Allavena P, Balotta C (1987) Tumor-associated leukocytes in metastasizing tumors. In: Herberman RB, Wiltrout RH, Gorelik E (eds) Immune responses to metastases, vol I. CRC, Boca Raton, pp 106–118
Mitchell RL, Zokas L, Schreiber RD, Verma IM (1985) Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation. Cell 40:209–217
Muller R, Curran T, Muller D, Guilbert L (1985) Induction of c-fos during myelomonocytic differentiation and macrophage proliferation. Nature 314:546–548
Radzioch D, Bottazzi B, Varesio L (1987) Augmentation of c-fos mRNA expression by activators of protein kinase C in fresh, terminally differentiated resting macrophages. Mol Cell Biol 7:595–599
Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley R (1985) The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell 41:665–676
Stewart CC (1983) Local proliferation of mononuclear phagocytes in tumors. RES Reticu-loendothel Soc 34:23–27
Stewart CC, Beetham KL (1978) Cytocidal activity and proliferative ability of macrophages infiltrating the EMT6 tumor. Int J Cancer 22:152–159
Wang J-M, Cianciolo GJ, Snyderman R, Mantovani A (1986) Coexistence of a chemotactic factor and a retroviral P15E-related chemotaxis inhibitor in human tumor cell culture supernatants. J Immunol 137:2726–2732
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© 1989 Springer-Verlag Berlin Heidelberg
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Bottazzi, B., Giavazzi, R., Nobili, N., Fazioli, F., Mantovani, A. (1989). The Role of Macrophages in the Regulation of Tumor Growth and Metastasis. In: Schirrmacher, V., Schwartz-Albiez, R. (eds) Cancer Metastasis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74236-1_15
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DOI: https://doi.org/10.1007/978-3-642-74236-1_15
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