Abstract
The acquisition of the ability to metastasize is the ultimate and most deadly level of the tumorigenic progression. Metastatic cells are able to dissociate from the primary tumor, invade through the surrounding tissue and endothelial layer into the bloodstream, migrate through the bloodstream to the site of metastasis and then reinvade and proliferate to generate a new tumor lesion (Poste and Fidler 1980). Throughout this process the metastatic cell assumes a number of different morphological configurations varying from densely packed within the tumor mass, deformed and elongated in invasion, and free-floating in the bloodstream. During each of these stages it must acquire distinct functional capabilities requiring the expression of distinct molecular entities.
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© 1989 Springer-Verlag Berlin Heidelberg
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Nabi, I.R., Raz, A. (1989). Cell Shape and the Metastatic Phenotype. In: Schirrmacher, V., Schwartz-Albiez, R. (eds) Cancer Metastasis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74236-1_12
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DOI: https://doi.org/10.1007/978-3-642-74236-1_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-50471-9
Online ISBN: 978-3-642-74236-1
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